Click here to access PB0066 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0066 P08582 Melanotransferrin MELTF CD228, MAP97, MFI2, MTF1, MTf Homo_sapiens Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

DomainsGene Ontology
PF00405 (2_Transferrin)
GO:0005506 (enables) iron ion binding
GO:0005515 (enables) protein binding
GO:0046872 (enables) metal ion binding
GO:0006811 (involved in) ion transport
GO:0006826 (involved in) iron ion transport
GO:0010756 (involved in) positive regulation of plasminogen activation
GO:0055072 (involved in) iron ion homeostasis
GO:0090091 (involved in) positive regulation of extracellular matrix disassembly
GO:1900025 (involved in) negative regulation of substrate adhesion-dependent cell spreading
GO:0005769 (is active in) early endosome
GO:0055037 (is active in) recycling endosome
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005886 (located in) plasma membrane
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0031225 (located in) anchored component of membrane
GO:0046658 (located in) anchored component of plasma membrane
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)