Click here to access PB0065 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0065 P35442 Thrombospondin-2 THBS2 TSP2 Homo_sapiens Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

DomainsGene Ontology
PF00090 (3_TSP_1)
PF00093 (VWC)
PF02412 (6_TSP_3)
PF05735 (TSP_C)
PF07645 (EGF_CA)
PF12947 (EGF_3)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0007155 (involved in) cell adhesion
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0051965 (involved in) positive regulation of synapse assembly
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0031012 (located in) extracellular matrix
GO:0031091 (located in) platelet alpha granule
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)