Click here to access PB0063 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0063 P22105 Tenascin-X TNXB EDS3, EDSCLL, EDSCLL1, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS, tenascin XB Homo_sapiens Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.

DomainsGene Ontology
PF00041 (31_fn3)
PF00147 (Fibrinogen_C)
PF07974 (2_EGF_2)
PF18720 (10_EGF_Tenascin)
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0008201 (enables) heparin binding
GO:0098633 (enables) collagen fibril binding
GO:0006629 (involved in) lipid metabolic process
GO:0006631 (involved in) fatty acid metabolic process
GO:0006641 (involved in) triglyceride metabolic process
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0030036 (involved in) actin cytoskeleton organization
GO:0030198 (involved in) extracellular matrix organization
GO:0030199 (involved in) collagen fibril organization
GO:0032963 (involved in) collagen metabolic process
GO:0043506 (involved in) regulation of JUN kinase activity
GO:0048251 (involved in) elastic fiber assembly
GO:0098609 (involved in) cell-cell adhesion
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0031012 (located in) extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)