Click here to access PB0059 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0059 P04083 Annexin A1 ANXA1 ANX1, LPC1 Homo_sapiens Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).

DomainsGene Ontology
PF00191 (Annexin)
GO:0005884 (colocalizes with) actin filament
GO:0004859 (enables) phospholipase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0005543 (enables) phospholipid binding
GO:0005544 (enables) calcium-dependent phospholipid binding
GO:0019834 (enables) phospholipase A2 inhibitor activity
GO:0046872 (enables) metal ion binding
GO:0048306 (enables) calcium-dependent protein binding
GO:0098641 (enables) cadherin binding involved in cell-cell adhesion
GO:0001780 (involved in) neutrophil homeostasis
GO:0002250 (involved in) adaptive immune response
GO:0002376 (involved in) immune system process
GO:0002548 (involved in) monocyte chemotaxis
GO:0002685 (involved in) regulation of leukocyte migration
GO:0006909 (involved in) phagocytosis
GO:0006954 (involved in) inflammatory response
GO:0007165 (involved in) signal transduction
GO:0007166 (involved in) cell surface receptor signaling pathway
GO:0007187 (involved in) G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0008360 (involved in) regulation of cell shape
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0010165 (involved in) response to X-ray
GO:0014839 (involved in) myoblast migration involved in skeletal muscle regeneration
GO:0018149 (involved in) peptide cross-linking
GO:0030073 (involved in) insulin secretion
GO:0030216 (involved in) keratinocyte differentiation
GO:0030850 (involved in) prostate gland development
GO:0031018 (involved in) endocrine pancreas development
GO:0031340 (involved in) positive regulation of vesicle fusion
GO:0031394 (involved in) positive regulation of prostaglandin biosynthetic process
GO:0031532 (involved in) actin cytoskeleton reorganization
GO:0032355 (involved in) response to estradiol
GO:0032508 (involved in) DNA duplex unwinding
GO:0032652 (involved in) regulation of interleukin-1 production
GO:0032717 (involved in) negative regulation of interleukin-8 production
GO:0032743 (involved in) positive regulation of interleukin-2 production
GO:0033031 (involved in) positive regulation of neutrophil apoptotic process
GO:0035924 (involved in) cellular response to vascular endothelial growth factor stimulus
GO:0042063 (involved in) gliogenesis
GO:0042102 (involved in) positive regulation of T cell proliferation
GO:0042127 (involved in) regulation of cell population proliferation
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043434 (involved in) response to peptide hormone
GO:0045087 (involved in) innate immune response
GO:0045627 (involved in) positive regulation of T-helper 1 cell differentiation
GO:0045629 (involved in) negative regulation of T-helper 2 cell differentiation
GO:0045920 (involved in) negative regulation of exocytosis
GO:0046632 (involved in) alpha-beta T cell differentiation
GO:0046883 (involved in) regulation of hormone secretion
GO:0050482 (involved in) arachidonic acid secretion
GO:0050727 (involved in) regulation of inflammatory response
GO:0070301 (involved in) cellular response to hydrogen peroxide
GO:0070365 (involved in) hepatocyte differentiation
GO:0070459 (involved in) prolactin secretion
GO:0070555 (involved in) response to interleukin-1
GO:0071385 (involved in) cellular response to glucocorticoid stimulus
GO:0071621 (involved in) granulocyte chemotaxis
GO:0090050 (involved in) positive regulation of cell migration involved in sprouting angiogenesis
GO:0090303 (involved in) positive regulation of wound healing
GO:0097350 (involved in) neutrophil clearance
GO:0098609 (involved in) cell-cell adhesion
GO:1900087 (involved in) positive regulation of G1/S transition of mitotic cell cycle
GO:1900138 (involved in) negative regulation of phospholipase A2 activity
GO:0001533 (located in) cornified envelope
GO:0001891 (located in) phagocytic cup
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005737 (located in) cytoplasm
GO:0005768 (located in) endosome
GO:0005769 (located in) early endosome
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005912 (located in) adherens junction
GO:0005925 (located in) focal adhesion
GO:0005929 (located in) cilium
GO:0009986 (located in) cell surface
GO:0010008 (located in) endosome membrane
GO:0016020 (located in) membrane
GO:0016323 (located in) basolateral plasma membrane
GO:0016324 (located in) apical plasma membrane
GO:0016328 (located in) lateral plasma membrane
GO:0019898 (located in) extrinsic component of membrane
GO:0030659 (located in) cytoplasmic vesicle membrane
GO:0031232 (located in) extrinsic component of external side of plasma membrane
GO:0031313 (located in) extrinsic component of endosome membrane
GO:0031410 (located in) cytoplasmic vesicle
GO:0031514 (located in) motile cilium
GO:0031901 (located in) early endosome membrane
GO:0031982 (located in) vesicle
GO:0042383 (located in) sarcolemma
GO:0042995 (located in) cell projection
GO:0070062 (located in) extracellular exosome
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)