Click here to access PB0058 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0058 P02787 Serotransferrin TF HEL-S-71p, PRO1557, PRO2086, TFQTL1, transferrin Homo_sapiens (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.

DomainsGene Ontology
PF00405 (2_Transferrin)
GO:0005515 (enables) protein binding
GO:0008198 (enables) ferrous iron binding
GO:0008199 (enables) ferric iron binding
GO:0034986 (enables) iron chaperone activity
GO:0046872 (enables) metal ion binding
GO:1990459 (enables) transferrin receptor binding
GO:0001895 (involved in) retina homeostasis
GO:0006811 (involved in) ion transport
GO:0006826 (involved in) iron ion transport
GO:0006879 (involved in) cellular iron ion homeostasis
GO:0007015 (involved in) actin filament organization
GO:0009617 (involved in) response to bacterium
GO:0019731 (involved in) antibacterial humoral response
GO:0030316 (involved in) osteoclast differentiation
GO:0034756 (involved in) regulation of iron ion transport
GO:0042327 (involved in) positive regulation of phosphorylation
GO:0045780 (involved in) positive regulation of bone resorption
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0048260 (involved in) positive regulation of receptor-mediated endocytosis
GO:0055072 (involved in) iron ion homeostasis
GO:0060395 (involved in) SMAD protein signal transduction
GO:0070371 (involved in) ERK1 and ERK2 cascade
GO:0071281 (involved in) cellular response to iron ion
GO:2000147 (involved in) positive regulation of cell motility
GO:0005886 (is active in) plasma membrane
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005768 (located in) endosome
GO:0005769 (located in) early endosome
GO:0005770 (located in) late endosome
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005905 (located in) clathrin-coated pit
GO:0009925 (located in) basal plasma membrane
GO:0009986 (located in) cell surface
GO:0010008 (located in) endosome membrane
GO:0016020 (located in) membrane
GO:0016324 (located in) apical plasma membrane
GO:0030139 (located in) endocytic vesicle
GO:0030669 (located in) clathrin-coated endocytic vesicle membrane
GO:0031232 (located in) extrinsic component of external side of plasma membrane
GO:0031410 (located in) cytoplasmic vesicle
GO:0031982 (located in) vesicle
GO:0034774 (located in) secretory granule lumen
GO:0045178 (located in) basal part of cell
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0055037 (located in) recycling endosome
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:1990712 (part of) HFE-transferrin receptor complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)