Click here to access PB0057 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0057 P26583 High mobility group protein B2 HMGB2 HMG2, high mobility group box 2 Homo_sapiens Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).

DomainsGene Ontology
PF00505 (HMG_box)
PF09011 (HMG_box_2)
GO:0000400 (enables) four-way junction DNA binding
GO:0000976 (enables) transcription cis-regulatory region binding
GO:0000987 (enables) cis-regulatory region sequence-specific DNA binding
GO:0003677 (enables) DNA binding
GO:0003684 (enables) damaged DNA binding
GO:0003690 (enables) double-stranded DNA binding
GO:0003697 (enables) single-stranded DNA binding
GO:0003713 (enables) transcription coactivator activity
GO:0003723 (enables) RNA binding
GO:0005515 (enables) protein binding
GO:0008134 (enables) transcription factor binding
GO:0008301 (enables) DNA binding, bending
GO:0019904 (enables) protein domain specific binding
GO:0042056 (enables) chemoattractant activity
GO:0044378 (enables) non-sequence-specific DNA binding, bending
GO:0050786 (enables) RAGE receptor binding
GO:0097100 (enables) supercoiled DNA binding
GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II
GO:0001938 (involved in) positive regulation of endothelial cell proliferation
GO:0002376 (involved in) immune system process
GO:0002437 (involved in) inflammatory response to antigenic stimulus
GO:0006265 (involved in) DNA topological change
GO:0006303 (involved in) double-strand break repair via nonhomologous end joining
GO:0006310 (involved in) DNA recombination
GO:0006325 (involved in) chromatin organization
GO:0006334 (involved in) nucleosome assembly
GO:0006357 (involved in) regulation of transcription by RNA polymerase II
GO:0006935 (involved in) chemotaxis
GO:0006954 (involved in) inflammatory response
GO:0007283 (involved in) spermatogenesis
GO:0007289 (involved in) spermatid nucleus differentiation
GO:0008584 (involved in) male gonad development
GO:0010628 (involved in) positive regulation of gene expression
GO:0010629 (involved in) negative regulation of gene expression
GO:0032075 (involved in) positive regulation of nuclease activity
GO:0032392 (involved in) DNA geometric change
GO:0032496 (involved in) response to lipopolysaccharide
GO:0032728 (involved in) positive regulation of interferon-beta production
GO:0033151 (involved in) V(D)J recombination
GO:0043388 (involved in) positive regulation of DNA binding
GO:0045087 (involved in) innate immune response
GO:0045089 (involved in) positive regulation of innate immune response
GO:0045648 (involved in) positive regulation of erythrocyte differentiation
GO:0045654 (involved in) positive regulation of megakaryocyte differentiation
GO:0045892 (involved in) negative regulation of transcription, DNA-templated
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II
GO:0048545 (involved in) response to steroid hormone
GO:0050767 (involved in) regulation of neurogenesis
GO:0050829 (involved in) defense response to Gram-negative bacterium
GO:0050830 (involved in) defense response to Gram-positive bacterium
GO:0050918 (involved in) positive chemotaxis
GO:0060326 (involved in) cell chemotaxis
GO:0071222 (involved in) cellular response to lipopolysaccharide
GO:0072091 (involved in) regulation of stem cell proliferation
GO:1902042 (involved in) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0000785 (located in) chromatin
GO:0000793 (located in) condensed chromosome
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005694 (located in) chromosome
GO:0005730 (located in) nucleolus
GO:0005737 (located in) cytoplasm
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0032991 (part of) protein-containing complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)