Click here to access PB0056 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0056 P08294 Extracellular superoxide dismutase [Cu-Zn] SOD3 EC-SOD, superoxide dismutase 3 Homo_sapiens Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

DomainsGene Ontology
PF00080 (Sod_Cu)
GO:0004784 (enables) superoxide dismutase activity
GO:0005507 (enables) copper ion binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0016209 (enables) antioxidant activity
GO:0016491 (enables) oxidoreductase activity
GO:0046872 (enables) metal ion binding
GO:0001666 (involved in) response to hypoxia
GO:0006801 (involved in) superoxide metabolic process
GO:0006979 (involved in) response to oxidative stress
GO:0019430 (involved in) removal of superoxide radicals
GO:0046688 (involved in) response to copper ion
GO:0097746 (involved in) blood vessel diameter maintenance
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005794 (located in) Golgi apparatus
GO:0005796 (located in) Golgi lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)