Click here to access PB0053 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0053 P55268 Laminin subunit beta-2 LAMB2 LAMS, NPHS5, PIERS Homo_sapiens Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

DomainsGene Ontology
PF00053 (13_Laminin_EGF)
PF00055 (Laminin_N)
GO:0005178 (enables) integrin binding
GO:0005198 (enables) structural molecule activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0000904 (involved in) cell morphogenesis involved in differentiation
GO:0007155 (involved in) cell adhesion
GO:0007411 (involved in) axon guidance
GO:0007528 (involved in) neuromuscular junction development
GO:0007601 (involved in) visual perception
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0014002 (involved in) astrocyte development
GO:0014044 (involved in) Schwann cell development
GO:0016477 (involved in) cell migration
GO:0031175 (involved in) neuron projection development
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0048677 (involved in) axon extension involved in regeneration
GO:0050808 (involved in) synapse organization
GO:0060041 (involved in) retina development in camera-type eye
GO:0070831 (involved in) basement membrane assembly
GO:0072249 (involved in) metanephric glomerular visceral epithelial cell development
GO:0072274 (involved in) metanephric glomerular basement membrane development
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0031594 (located in) neuromuscular junction
GO:0043083 (located in) synaptic cleft
GO:0045202 (located in) synapse
GO:0070062 (located in) extracellular exosome
GO:0005608 (part of) laminin-3 complex
GO:0043256 (part of) laminin complex
GO:0043260 (part of) laminin-11 complex
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)