Click here to access PB0049 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0049 P06727 Apolipoprotein A-IV APOA4 apolipoprotein A4 Homo_sapiens May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

DomainsGene Ontology
PF01442 (2_Apolipoprotein)
GO:0009986 (colocalizes with) cell surface
GO:0005319 (enables) lipid transporter activity
GO:0005507 (enables) copper ion binding
GO:0005515 (enables) protein binding
GO:0005543 (enables) phospholipid binding
GO:0008289 (enables) lipid binding
GO:0015485 (enables) cholesterol binding
GO:0016209 (enables) antioxidant activity
GO:0031210 (enables) phosphatidylcholine binding
GO:0042802 (enables) identical protein binding
GO:0042803 (enables) protein homodimerization activity
GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0120020 (enables) cholesterol transfer activity
GO:0002227 (involved in) innate immune response in mucosa
GO:0006695 (involved in) cholesterol biosynthetic process
GO:0006869 (involved in) lipid transport
GO:0006982 (involved in) response to lipid hydroperoxide
GO:0007159 (involved in) leukocyte cell-cell adhesion
GO:0008203 (involved in) cholesterol metabolic process
GO:0010873 (involved in) positive regulation of cholesterol esterification
GO:0010898 (involved in) positive regulation of triglyceride catabolic process
GO:0014012 (involved in) peripheral nervous system axon regeneration
GO:0016042 (involved in) lipid catabolic process
GO:0019430 (involved in) removal of superoxide radicals
GO:0030300 (involved in) regulation of intestinal cholesterol absorption
GO:0032374 (involved in) regulation of cholesterol transport
GO:0033344 (involved in) cholesterol efflux
GO:0033700 (involved in) phospholipid efflux
GO:0034014 (involved in) response to triglyceride
GO:0034371 (involved in) chylomicron remodeling
GO:0034372 (involved in) very-low-density lipoprotein particle remodeling
GO:0034375 (involved in) high-density lipoprotein particle remodeling
GO:0034378 (involved in) chylomicron assembly
GO:0034380 (involved in) high-density lipoprotein particle assembly
GO:0034445 (involved in) negative regulation of plasma lipoprotein oxidation
GO:0035634 (involved in) response to stilbenoid
GO:0042157 (involved in) lipoprotein metabolic process
GO:0042632 (involved in) cholesterol homeostasis
GO:0042744 (involved in) hydrogen peroxide catabolic process
GO:0043691 (involved in) reverse cholesterol transport
GO:0045723 (involved in) positive regulation of fatty acid biosynthetic process
GO:0046470 (involved in) phosphatidylcholine metabolic process
GO:0046889 (involved in) positive regulation of lipid biosynthetic process
GO:0051006 (involved in) positive regulation of lipoprotein lipase activity
GO:0055088 (involved in) lipid homeostasis
GO:0065005 (involved in) protein-lipid complex assembly
GO:0070328 (involved in) triglyceride homeostasis
GO:0120009 (involved in) intermembrane lipid transfer
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005769 (located in) early endosome
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005829 (located in) cytosol
GO:0045202 (located in) synapse
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0034361 (part of) very-low-density lipoprotein particle
GO:0034364 (part of) high-density lipoprotein particle
GO:0042627 (part of) chylomicron

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)