Click here to access PB0047 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0047 P02652 Apolipoprotein A-II APOA2 Apo-AII, ApoA-II, apoAII, apolipoprotein A2 Homo_sapiens May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

DomainsGene Ontology
PF04711 (ApoA-II)
GO:0120020 (contributes to) cholesterol transfer activity
GO:0005102 (enables) signaling receptor binding
GO:0005319 (enables) lipid transporter activity
GO:0005515 (enables) protein binding
GO:0005543 (enables) phospholipid binding
GO:0008035 (enables) high-density lipoprotein particle binding
GO:0008289 (enables) lipid binding
GO:0015485 (enables) cholesterol binding
GO:0031072 (enables) heat shock protein binding
GO:0031210 (enables) phosphatidylcholine binding
GO:0034190 (enables) apolipoprotein receptor binding
GO:0042803 (enables) protein homodimerization activity
GO:0046982 (enables) protein heterodimerization activity
GO:0055102 (enables) lipase inhibitor activity
GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653 (enables) high-density lipoprotein particle receptor binding
GO:0002526 (involved in) acute inflammatory response
GO:0002719 (involved in) negative regulation of cytokine production involved in immune response
GO:0006641 (involved in) triglyceride metabolic process
GO:0006656 (involved in) phosphatidylcholine biosynthetic process
GO:0006869 (involved in) lipid transport
GO:0008203 (involved in) cholesterol metabolic process
GO:0009395 (involved in) phospholipid catabolic process
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009749 (involved in) response to glucose
GO:0010873 (involved in) positive regulation of cholesterol esterification
GO:0010903 (involved in) negative regulation of very-low-density lipoprotein particle remodeling
GO:0018158 (involved in) protein oxidation
GO:0018206 (involved in) peptidyl-methionine modification
GO:0030300 (involved in) regulation of intestinal cholesterol absorption
GO:0030301 (involved in) cholesterol transport
GO:0031100 (involved in) animal organ regeneration
GO:0031647 (involved in) regulation of protein stability
GO:0032375 (involved in) negative regulation of cholesterol transport
GO:0032757 (involved in) positive regulation of interleukin-8 production
GO:0033344 (involved in) cholesterol efflux
GO:0033700 (involved in) phospholipid efflux
GO:0034370 (involved in) triglyceride-rich lipoprotein particle remodeling
GO:0034374 (involved in) low-density lipoprotein particle remodeling
GO:0034375 (involved in) high-density lipoprotein particle remodeling
GO:0034380 (involved in) high-density lipoprotein particle assembly
GO:0034384 (involved in) high-density lipoprotein particle clearance
GO:0042157 (involved in) lipoprotein metabolic process
GO:0042632 (involved in) cholesterol homeostasis
GO:0043627 (involved in) response to estrogen
GO:0043691 (involved in) reverse cholesterol transport
GO:0046340 (involved in) diacylglycerol catabolic process
GO:0050766 (involved in) positive regulation of phagocytosis
GO:0050821 (involved in) protein stabilization
GO:0050995 (involved in) negative regulation of lipid catabolic process
GO:0050996 (involved in) positive regulation of lipid catabolic process
GO:0051384 (involved in) response to glucocorticoid
GO:0060192 (involved in) negative regulation of lipase activity
GO:0060621 (involved in) negative regulation of cholesterol import
GO:0060695 (involved in) negative regulation of cholesterol transporter activity
GO:0120009 (involved in) intermembrane lipid transfer
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005769 (located in) early endosome
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005829 (located in) cytosol
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0034361 (part of) very-low-density lipoprotein particle
GO:0034364 (part of) high-density lipoprotein particle
GO:0034366 (part of) spherical high-density lipoprotein particle
GO:0042627 (part of) chylomicron

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)