Click here to access PB0045 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0045 O00391 Sulfhydryl oxidase 1 QSOX1 Q6, QSCN6, quiescin sulfhydryl oxidase 1 Homo_sapiens In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).

DomainsGene Ontology
PF00085 (Thioredoxin)
PF04777 (Evr1_Alr)
PF18108 (QSOX_Trx1)
PF18371 (FAD_SOX)
GO:0003756 (enables) protein disulfide isomerase activity
GO:0016491 (enables) oxidoreductase activity
GO:0016971 (enables) flavin-linked sulfhydryl oxidase activity
GO:0016972 (enables) thiol oxidase activity
GO:0071949 (enables) FAD binding
GO:0006457 (involved in) protein folding
GO:0016242 (involved in) negative regulation of macroautophagy
GO:0085029 (involved in) extracellular matrix assembly
GO:0005615 (is active in) extracellular space
GO:0030173 (is active in) integral component of Golgi membrane
GO:0000139 (located in) Golgi membrane
GO:0005576 (located in) extracellular region
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0031093 (located in) platelet alpha granule lumen
GO:0035580 (located in) specific granule lumen
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0045171 (located in) intercellular bridge
GO:0070062 (located in) extracellular exosome
GO:1904724 (located in) tertiary granule lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)