PB0042
DATABASE


Click here to access PB0042 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0042 P48307 Tissue factor pathway inhibitor 2 TFPI2 PP5, REF1, TFPI-2 Homo_sapiens May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

DomainsGene Ontology
PF00014 (3_Kunitz_BPTI)
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0030414 (enables) peptidase inhibitor activity
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0071498 (involved in) cellular response to fluid shear stress
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0031012 (located in) extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences


Created by Puigbo and Nakamura @ University of Turku (2022)