Click here to access PB0040 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0040 P27658 Collagen alpha-1(VIII) chain COL8A1 C3orf7, collagen type VIII alpha 1 chain Homo_sapiens Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.

DomainsGene Ontology
PF00386 (C1q)
PF01391 (2_Collagen)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0001525 (involved in) angiogenesis
GO:0007155 (involved in) cell adhesion
GO:0030198 (involved in) extracellular matrix organization
GO:0035987 (involved in) endodermal cell differentiation
GO:0048593 (involved in) camera-type eye morphogenesis
GO:0050673 (involved in) epithelial cell proliferation
GO:0005615 (is active in) extracellular space
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005581 (part of) collagen trimer
GO:0005591 (part of) collagen type VIII trimer
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)