Click here to access PB0039 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0039 O75829 Leukocyte cell-derived chemotaxin 1 CNMD BRICD3, CHM-I, CHM1, LECT1, MYETS1, chondromodulin Homo_sapiens Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.

DomainsGene Ontology
GO:0001501 (involved in) skeletal system development
GO:0001886 (involved in) endothelial cell morphogenesis
GO:0001937 (involved in) negative regulation of endothelial cell proliferation
GO:0006029 (involved in) proteoglycan metabolic process
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0030154 (involved in) cell differentiation
GO:0030948 (involved in) negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0051216 (involved in) cartilage development
GO:0005576 (located in) extracellular region
GO:0012505 (located in) endomembrane system
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)