PB0038
DATABASE


Click here to access PB0038 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0038 P24593 Insulin-like growth factor-binding protein 5 IGFBP5 IBP5 Homo_sapiens IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

DomainsGene Ontology
PF00086 (Thyroglobulin_1)
PF00219 (IGFBP)
GO:0001968 (enables) fibronectin binding
GO:0005515 (enables) protein binding
GO:0005520 (enables) insulin-like growth factor binding
GO:0019838 (enables) growth factor binding
GO:0031994 (enables) insulin-like growth factor I binding
GO:0031995 (enables) insulin-like growth factor II binding
GO:0001558 (involved in) regulation of cell growth
GO:0001649 (involved in) osteoblast differentiation
GO:0007165 (involved in) signal transduction
GO:0007565 (involved in) female pregnancy
GO:0007568 (involved in) aging
GO:0014912 (involved in) negative regulation of smooth muscle cell migration
GO:0017148 (involved in) negative regulation of translation
GO:0030336 (involved in) negative regulation of cell migration
GO:0031069 (involved in) hair follicle morphogenesis
GO:0035556 (involved in) intracellular signal transduction
GO:0040008 (involved in) regulation of growth
GO:0042593 (involved in) glucose homeostasis
GO:0043567 (involved in) regulation of insulin-like growth factor receptor signaling pathway
GO:0043568 (involved in) positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043569 (involved in) negative regulation of insulin-like growth factor receptor signaling pathway
GO:0044342 (involved in) type B pancreatic cell proliferation
GO:0045668 (involved in) negative regulation of osteoblast differentiation
GO:0045926 (involved in) negative regulation of growth
GO:0048286 (involved in) lung alveolus development
GO:0048662 (involved in) negative regulation of smooth muscle cell proliferation
GO:0051146 (involved in) striated muscle cell differentiation
GO:0051897 (involved in) positive regulation of protein kinase B signaling
GO:0060056 (involved in) mammary gland involution
GO:0060416 (involved in) response to growth hormone
GO:0071320 (involved in) cellular response to cAMP
GO:0071407 (involved in) cellular response to organic cyclic compound
GO:1901862 (involved in) negative regulation of muscle tissue development
GO:1904205 (involved in) negative regulation of skeletal muscle hypertrophy
GO:1904707 (involved in) positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 (involved in) positive regulation of vascular associated smooth muscle cell migration
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0016942 (part of) insulin-like growth factor binding protein complex
GO:0042567 (part of) insulin-like growth factor ternary complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences


Created by Puigbo and Nakamura @ University of Turku (2022)