Click here to access PB0037 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0037 P22413 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1 Homo_sapiens Not able to hydrolyze the 2'-3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812).

DomainsGene Ontology
PF01033 (2_Somatomedin_B)
PF01223 (Endonuclease_NS)
PF01663 (Phosphodiest)
GO:0003676 (enables) nucleic acid binding
GO:0003824 (enables) catalytic activity
GO:0004527 (enables) exonuclease activity
GO:0004528 (enables) phosphodiesterase I activity
GO:0004551 (enables) nucleotide diphosphatase activity
GO:0005044 (enables) scavenger receptor activity
GO:0005158 (enables) insulin receptor binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0005524 (enables) ATP binding
GO:0008270 (enables) zinc ion binding
GO:0016787 (enables) hydrolase activity
GO:0030247 (enables) polysaccharide binding
GO:0035529 (enables) NADH pyrophosphatase activity
GO:0036218 (enables) dTTP diphosphatase activity
GO:0042803 (enables) protein homodimerization activity
GO:0046872 (enables) metal ion binding
GO:0047429 (enables) nucleoside-triphosphate diphosphatase activity
GO:0050656 (enables) 3'-phosphoadenosine 5'-phosphosulfate binding
GO:0106177 (enables) cyclic-GMP-AMP hydrolase activity
GO:0006091 (involved in) generation of precursor metabolites and energy
GO:0006796 (involved in) phosphate-containing compound metabolic process
GO:0006897 (involved in) endocytosis
GO:0006955 (involved in) immune response
GO:0009143 (involved in) nucleoside triphosphate catabolic process
GO:0030308 (involved in) negative regulation of cell growth
GO:0030318 (involved in) melanocyte differentiation
GO:0030500 (involved in) regulation of bone mineralization
GO:0030502 (involved in) negative regulation of bone mineralization
GO:0030505 (involved in) inorganic diphosphate transport
GO:0030643 (involved in) cellular phosphate ion homeostasis
GO:0030730 (involved in) sequestering of triglyceride
GO:0031214 (involved in) biomineral tissue development
GO:0031953 (involved in) negative regulation of protein autophosphorylation
GO:0032869 (involved in) cellular response to insulin stimulus
GO:0045599 (involved in) negative regulation of fat cell differentiation
GO:0045719 (involved in) negative regulation of glycogen biosynthetic process
GO:0046034 (involved in) ATP metabolic process
GO:0046325 (involved in) negative regulation of glucose import
GO:0046627 (involved in) negative regulation of insulin receptor signaling pathway
GO:0050427 (involved in) 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0090305 (involved in) nucleic acid phosphodiester bond hydrolysis
GO:1990787 (involved in) negative regulation of hh target transcription factor activity
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005765 (located in) lysosomal membrane
GO:0005886 (located in) plasma membrane
GO:0005887 (located in) integral component of plasma membrane
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0016323 (located in) basolateral plasma membrane

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)