Click here to access PB0036 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0036 Q92743 Serine protease HTRA1 HTRA1 ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11, HtrA serine peptidase 1 Homo_sapiens Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

DomainsGene Ontology
PF00219 (IGFBP)
PF07648 (Kazal_2)
PF17820 (PDZ_6)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0005520 (enables) insulin-like growth factor binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0019838 (enables) growth factor binding
GO:0042802 (enables) identical protein binding
GO:0001890 (involved in) placenta development
GO:0006508 (involved in) proteolysis
GO:0030512 (involved in) negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 (involved in) negative regulation of BMP signaling pathway
GO:0050679 (involved in) positive regulation of epithelial cell proliferation
GO:0050687 (involved in) negative regulation of defense response to virus
GO:0060718 (involved in) chorionic trophoblast cell differentiation
GO:0097187 (involved in) dentinogenesis
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)