Click here to access PB0035 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0035 P04070 Vitamin K-dependent protein C PROC APC, PC, PROC1, THPH3, THPH4, protein C, inactivator of coagulation factors Va and VIIIa Homo_sapiens Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).

DomainsGene Ontology
PF00008 (EGF)
PF00089 (Trypsin)
PF00594 (Gla)
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0006508 (involved in) proteolysis
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0030195 (involved in) negative regulation of blood coagulation
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0050728 (involved in) negative regulation of inflammatory response
GO:0050819 (involved in) negative regulation of coagulation
GO:1903142 (involved in) positive regulation of establishment of endothelial barrier
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0005796 (located in) Golgi lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)