Click here to access PB0034 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0034 P36980 Complement factor H-related protein 2 CFHR2 CFHL2, FHR2, HFL3 Homo_sapiens Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

DomainsGene Ontology
PF00084 (4_Sushi)
GO:0005515 (enables) protein binding
GO:0042802 (enables) identical protein binding
GO:0032091 (involved in) negative regulation of protein binding
GO:0051838 (involved in) cytolysis by host of symbiont cells
GO:0005576 (located in) extracellular region
GO:0032991 (part of) protein-containing complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)