Click here to access PB0033 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0033 P07355 Annexin A2 ANXA2 ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV Homo_sapiens Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.

DomainsGene Ontology
PF00191 (4_Annexin)
GO:0045121 (colocalizes with) membrane raft
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0001786 (enables) phosphatidylserine binding
GO:0002020 (enables) protease binding
GO:0003723 (enables) RNA binding
GO:0004859 (enables) phospholipase inhibitor activity
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005262 (enables) calcium channel activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0005544 (enables) calcium-dependent phospholipid binding
GO:0005546 (enables) phosphatidylinositol-4,5-bisphosphate binding
GO:0008092 (enables) cytoskeletal protein binding
GO:0019834 (enables) phospholipase A2 inhibitor activity
GO:0042802 (enables) identical protein binding
GO:0044548 (enables) S100 protein binding
GO:0046790 (enables) virion binding
GO:0048306 (enables) calcium-dependent protein binding
GO:0098641 (enables) cadherin binding involved in cell-cell adhesion
GO:0001525 (involved in) angiogenesis
GO:0001765 (involved in) membrane raft assembly
GO:0001921 (involved in) positive regulation of receptor recycling
GO:0006900 (involved in) vesicle budding from membrane
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0031340 (involved in) positive regulation of vesicle fusion
GO:0032804 (involved in) negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0036035 (involved in) osteoclast development
GO:0043086 (involved in) negative regulation of catalytic activity
GO:0044090 (involved in) positive regulation of vacuole organization
GO:0070588 (involved in) calcium ion transmembrane transport
GO:0098609 (involved in) cell-cell adhesion
GO:1905581 (involved in) positive regulation of low-density lipoprotein particle clearance
GO:1905597 (involved in) positive regulation of low-density lipoprotein particle receptor binding
GO:1905599 (involved in) positive regulation of low-density lipoprotein receptor activity
GO:1905602 (involved in) positive regulation of receptor-mediated endocytosis involved in cholesterol transport
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005765 (located in) lysosomal membrane
GO:0005768 (located in) endosome
GO:0005811 (located in) lipid droplet
GO:0005886 (located in) plasma membrane
GO:0005912 (located in) adherens junction
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0016323 (located in) basolateral plasma membrane
GO:0030496 (located in) midbody
GO:0031902 (located in) late endosome membrane
GO:0031982 (located in) vesicle
GO:0035578 (located in) azurophil granule lumen
GO:0042470 (located in) melanosome
GO:0070062 (located in) extracellular exosome
GO:1990665 (part of) AnxA2-p11 complex
GO:1990667 (part of) PCSK9-AnxA2 complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)