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PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0032 Q53GQ0 Very-long-chain 3-oxoacyl-CoA reductase HSD17B12 hydroxysteroid 17-beta dehydrogenase 12, KAR, SDR12C1 Homo_sapiens Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

DomainsGene Ontology
PF00106 (adh_short)
GO:0001968 (enables) fibronectin binding
GO:0004303 (enables) estradiol 17-beta-dehydrogenase activity
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0008201 (enables) heparin binding
GO:0016491 (enables) oxidoreductase activity
GO:0016509 (enables) long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0044594 (enables) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0050062 (enables) long-chain-fatty-acyl-CoA reductase activity
GO:0072582 (enables) 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0102339 (enables) 3-oxo-arachidoyl-CoA reductase activity
GO:0102340 (enables) 3-oxo-behenoyl-CoA reductase activity
GO:0102341 (enables) 3-oxo-lignoceroyl-CoA reductase activity
GO:0102342 (enables) 3-oxo-cerotoyl-CoA reductase activity
GO:0006629 (involved in) lipid metabolic process
GO:0006633 (involved in) fatty acid biosynthetic process
GO:0006694 (involved in) steroid biosynthetic process
GO:0006703 (involved in) estrogen biosynthetic process
GO:0010811 (involved in) positive regulation of cell-substrate adhesion
GO:0030198 (involved in) extracellular matrix organization
GO:0035338 (involved in) long-chain fatty-acyl-CoA biosynthetic process
GO:0005783 (located in) endoplasmic reticulum
GO:0005789 (located in) endoplasmic reticulum membrane
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0031012 (located in) extracellular matrix
GO:0009923 (part of) fatty acid elongase complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)