Click here to access PB0030 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0030 P01024 Complement C3 C3 AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p Homo_sapiens It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

DomainsGene Ontology
PF00207 (A2M)
PF01759 (NTR)
PF01821 (ANATO)
PF01835 (MG2)
PF07677 (A2M_recep)
PF07678 (TED_complement)
PF07703 (A2M_BRD)
PF17789 (MG4)
PF17790 (MG1)
PF17791 (MG3)
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0031715 (enables) C5L2 anaphylatoxin chemotactic receptor binding
GO:0001798 (involved in) positive regulation of type IIa hypersensitivity
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0001970 (involved in) positive regulation of activation of membrane attack complex
GO:0002376 (involved in) immune system process
GO:0006629 (involved in) lipid metabolic process
GO:0006631 (involved in) fatty acid metabolic process
GO:0006954 (involved in) inflammatory response
GO:0006955 (involved in) immune response
GO:0006956 (involved in) complement activation
GO:0006957 (involved in) complement activation, alternative pathway
GO:0006958 (involved in) complement activation, classical pathway
GO:0007165 (involved in) signal transduction
GO:0007186 (involved in) G protein-coupled receptor signaling pathway
GO:0009617 (involved in) response to bacterium
GO:0010575 (involved in) positive regulation of vascular endothelial growth factor production
GO:0010828 (involved in) positive regulation of glucose transmembrane transport
GO:0010866 (involved in) regulation of triglyceride biosynthetic process
GO:0010884 (involved in) positive regulation of lipid storage
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0016322 (involved in) neuron remodeling
GO:0035846 (involved in) oviduct epithelium development
GO:0045087 (involved in) innate immune response
GO:0045745 (involved in) positive regulation of G protein-coupled receptor signaling pathway
GO:0045766 (involved in) positive regulation of angiogenesis
GO:0048260 (involved in) positive regulation of receptor-mediated endocytosis
GO:0050766 (involved in) positive regulation of phagocytosis
GO:0060100 (involved in) positive regulation of phagocytosis, engulfment
GO:0097242 (involved in) amyloid-beta clearance
GO:0097278 (involved in) complement-dependent cytotoxicity
GO:0150062 (involved in) complement-mediated synapse pruning
GO:0150064 (involved in) vertebrate eye-specific patterning
GO:1905114 (involved in) cell surface receptor signaling pathway involved in cell-cell signaling
GO:2000427 (involved in) positive regulation of apoptotic cell clearance
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005886 (located in) plasma membrane
GO:0009986 (located in) cell surface
GO:0034774 (located in) secretory granule lumen
GO:0035578 (located in) azurophil granule lumen
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0032991 (part of) protein-containing complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)