Click here to access PB0026 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0026 Q08431 Milk fat globule EGF and factor V/VIII domain containing MFGE8 BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, Lactadherin Homo_sapiens Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.

DomainsGene Ontology
PF00008 (EGF)
PF00754 (2_F5_F8_type_C)
GO:0001786 (enables) phosphatidylserine binding
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0008429 (enables) phosphatidylethanolamine binding
GO:0001525 (involved in) angiogenesis
GO:0006910 (involved in) phagocytosis, recognition
GO:0006911 (involved in) phagocytosis, engulfment
GO:0007155 (involved in) cell adhesion
GO:0007338 (involved in) single fertilization
GO:0043277 (involved in) apoptotic cell clearance
GO:0050766 (involved in) positive regulation of phagocytosis
GO:0002080 (located in) acrosomal membrane
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0009897 (located in) external side of plasma membrane
GO:0016020 (located in) membrane
GO:0019897 (located in) extrinsic component of plasma membrane
GO:0031410 (located in) cytoplasmic vesicle
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:1903561 (located in) extracellular vesicle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)