Click here to access PB0025 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0025 P02751 Fibronectin 1 FN1 CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF Homo_sapiens Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).

DomainsGene Ontology
PF00039 (12_fn1)
PF00040 (2_fn2)
PF00041 (17_fn3)
GO:0002020 (enables) protease binding
GO:0005102 (enables) signaling receptor binding
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0008022 (enables) protein C-terminus binding
GO:0008201 (enables) heparin binding
GO:0016504 (enables) peptidase activator activity
GO:0019899 (enables) enzyme binding
GO:0042802 (enables) identical protein binding
GO:0043394 (enables) proteoglycan binding
GO:0051087 (enables) chaperone binding
GO:0097718 (enables) disordered domain specific binding
GO:0001525 (involved in) angiogenesis
GO:0001932 (involved in) regulation of protein phosphorylation
GO:0006953 (involved in) acute-phase response
GO:0007044 (involved in) cell-substrate junction assembly
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0007161 (involved in) calcium-independent cell-matrix adhesion
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0007399 (involved in) nervous system development
GO:0007507 (involved in) heart development
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008360 (involved in) regulation of cell shape
GO:0009611 (involved in) response to wounding
GO:0010628 (involved in) positive regulation of gene expression
GO:0010952 (involved in) positive regulation of peptidase activity
GO:0014068 (involved in) positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018149 (involved in) peptide cross-linking
GO:0033622 (involved in) integrin activation
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0035987 (involved in) endodermal cell differentiation
GO:0042060 (involved in) wound healing
GO:0045773 (involved in) positive regulation of axon extension
GO:0048146 (involved in) positive regulation of fibroblast proliferation
GO:0051702 (involved in) biological process involved in interaction with symbiont
GO:0070372 (involved in) regulation of ERK1 and ERK2 cascade
GO:0070527 (involved in) platelet aggregation
GO:0071635 (involved in) negative regulation of transforming growth factor beta production
GO:0072378 (involved in) blood coagulation, fibrin clot formation
GO:0150102 (involved in) negative regulation of monocyte activation
GO:1901166 (involved in) neural crest cell migration involved in autonomic nervous system development
GO:1904237 (involved in) positive regulation of substrate-dependent cell migration, cell attachment to substrate
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005793 (located in) endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 (located in) plasma membrane
GO:0016324 (located in) apical plasma membrane
GO:0031012 (located in) extracellular matrix
GO:0031093 (located in) platelet alpha granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0005577 (part of) fibrinogen complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)