Click here to access PB0023 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0023 P12645 Bone morphogenetic protein 3 BMP3 BMP-3A Homo_sapiens Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification (PubMed:11138004, PubMed:15269709).

DomainsGene Ontology
PF00019 (TGF_beta)
GO:0005102 (enables) signaling receptor binding
GO:0005125 (enables) cytokine activity
GO:0008083 (enables) growth factor activity
GO:0070700 (enables) BMP receptor binding
GO:0001501 (involved in) skeletal system development
GO:0001503 (involved in) ossification
GO:0001649 (involved in) osteoblast differentiation
GO:0007267 (involved in) cell-cell signaling
GO:0010862 (involved in) positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030154 (involved in) cell differentiation
GO:0051216 (involved in) cartilage development
GO:0060395 (involved in) SMAD protein signal transduction
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)