Click here to access PB0022 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0022 Q9Y4K0 lysyl oxidase like 2 LOXL2 LOR, LOR2, WS9-14, Lysyl oxidase homolog 2 Homo_sapiens Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity).

DomainsGene Ontology
PF00530 (4_SRCR)
PF01186 (Lysyl_oxidase)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0004720 (enables) protein-lysine 6-oxidase activity
GO:0005044 (enables) scavenger receptor activity
GO:0005507 (enables) copper ion binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0009055 (enables) electron transfer activity
GO:0016491 (enables) oxidoreductase activity
GO:0016641 (enables) oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0046872 (enables) metal ion binding
GO:0070492 (enables) oligosaccharide binding
GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II
GO:0001666 (involved in) response to hypoxia
GO:0001837 (involved in) epithelial to mesenchymal transition
GO:0001935 (involved in) endothelial cell proliferation
GO:0002040 (involved in) sprouting angiogenesis
GO:0006325 (involved in) chromatin organization
GO:0006464 (involved in) cellular protein modification process
GO:0006897 (involved in) endocytosis
GO:0007155 (involved in) cell adhesion
GO:0007568 (involved in) aging
GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition
GO:0018057 (involved in) peptidyl-lysine oxidation
GO:0022900 (involved in) electron transport chain
GO:0030199 (involved in) collagen fibril organization
GO:0032332 (involved in) positive regulation of chondrocyte differentiation
GO:0043542 (involved in) endothelial cell migration
GO:0045892 (involved in) negative regulation of transcription, DNA-templated
GO:0046688 (involved in) response to copper ion
GO:0070828 (involved in) heterochromatin organization
GO:1902455 (involved in) negative regulation of stem cell population maintenance
GO:0000785 (located in) chromatin
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005694 (located in) chromosome
GO:0005783 (located in) endoplasmic reticulum
GO:0016020 (located in) membrane

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)