PB0020

DATABASE

Click here to access PB0020 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0020	Q9BRR6	ADP-dependent glucokinase	ADPGK	2610017G09Rik, ADP-GK	Homo_sapiens	Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.

Domains

Gene Ontology

PF04587 (ADP_PFK_GK)

GO:0006006 (acts upstream of or within) glucose metabolic process GO:0016301 (enables) kinase activity GO:0016740 (enables) transferase activity GO:0016773 (enables) phosphotransferase activity, alcohol group as acceptor GO:0043843 (enables) ADP-specific glucokinase activity GO:0046872 (enables) metal ion binding GO:0005975 (involved in) carbohydrate metabolic process GO:0006096 (involved in) glycolytic process GO:0016310 (involved in) phosphorylation GO:0061620 (involved in) glycolytic process through glucose-6-phosphate GO:0005783 (is active in) endoplasmic reticulum GO:0005576 (located in) extracellular region GO:0005789 (located in) endoplasmic reticulum membrane GO:0016020 (located in) membrane

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q9BRR6|ADPGK_HUMAN ADP-dependent glucokinase OS=Homo sapiens OX=9606 GN=ADPGK PE=1 SV=1 MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAA WDALIVRPVRRWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFI HFMGKGAAAERFFSDKETFHDIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGP VGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGQLKAPHANRFIFSHDLSNGAM NMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELAS MTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILF WILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLG DAISAEGLFYSEVHPHY >tr|A0JML7|A0JML7_DANRE ADP-dependent glucokinase OS=Danio rerio OX=7955 GN=adpgk PE=1 SV=1 MWRKAVLVAVLALGMGYLYHTDPELPARMLSYVSQSLPPMEAGGGSEPRPPTLEEAIARA WQTLITAPARRWGRVAVGVNACVDVVVSGVGLLQALALEPGSGRDHEVLHSKEDLKEAFI HYMGKGAAAERFFSDKEVFQRIARAAAEYPGAQLYVGGNAALIGQKLASNPQLVVLLCGP VGPKLHEMLDEQIVVPPESLQETDEYHLILEYKSGEQWGPSRAPQANRFILSHDVSNGEM SALEMFVASLEEFQPDLVVLSGLHMMEGMGRELWEERLKEAVVAISDVRNEVPIHLELAS MTDRDYMNRILQEQVMPIVNSIGLNEQELLFLTQSGGGPHSDLTSWDGVPDVGRVTDILL WVLEQHGRADAQSEADLTRIHFHTLAYHILATVDGHWGNQAAAVAAGARVASSQACGLQT IDISKVLLKAPLNFHSSFSEPRESLKVEPSRPVTVWRRGNVSFHLTPVLVCKQPLRTVGL GDAISAEGLVFSELTSEV
Selected proteins from model organisms >NP_082397.1 ADP-dependent glucokinase isoform 1 precursor [Mus musculus] MALWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPVGPLSPESRLAAAWDALIAQPAR RWRRVAVGVNACVDVVISGVKLLQALGLSPGSGKDHAILHSRSDLEEAFLYFMGKGAAAERFFSDKETFH DIAQAASEFPGAQHYVGGNAALIGQRFAANTDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLIL EYLAGEEWGPFKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLE VVTAISDIPTGIPVHLELASMTNRELMSSIVHQQVFPTVASLGLNEQELLFLSQSASGPHASLSSWDGVP DVGMVSDILFWILKEHGRSENRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTNRVSLRAPQEFTTSHLESGSRIVLNPDKPVVEWHREGITFHFTPVLVCKDPVRTVGLGDAISAEGLFY SEARPD >KAB0375010.1 hypothetical protein FD755_013502 [Muntiacus reevesi] MALWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRPARRWRRVAVGVN ACVDVVLSGVKLLRALGLSPGNGKDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPEAQHYVGGNA ALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDELKAPHANRFIFSHDLSNGAM NMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSLSDIPTGVPVHLELASMTNKELMSNIVHQQVFPAVT SLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHGKSESRASDLSRIHFHTLAYHILATVDGHWANQL AAVAAGARVAGTQACATETIDTRRVSLKAPHEFMTSRLEAGSRVVLNPSEPVVAWHREGVSFHFTPVLVCKDPVRTVGLG DAISAEGLFYSEVHPHL >KAB0342610.1 hypothetical protein FD754_019536 [Muntiacus muntjak] MALWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRPARRWRRVAVGVN ACVDVVLSGVKLLRALGLSPGNGKDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPEAQHYVGGNA ALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDELKAPHANRFIFSHDLSNGAM SMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSLSDIPTGVPVHLELASMTNKELMSNIVHQQVFPAVT SLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHGKSESRASDLSRIHFHTLAYHILATVDGHWANQL AAVAAGARVAGTQACATETIDTRRVSLKAPHEFMTSRLEAGSRVVLNPSEPVVAWHREGVSFHFTPVLVCKDPVRTVGLG DAISAEGLFYSEVHPHL >XP_043326947.1 ADP-dependent glucokinase isoform X1 [Cervus canadensis] MALWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRPARRWRRVAVGVN ACVDVVLSGVKLLRALGLSPGNGRDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPEAQHYVGGNA ALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDQLKAPHANRFIFSHDLSNGAM NMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSLSDIPMGVPVHLELASMTNKELMSNIVHQQVFPAVT SLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHGKSESRASDLSRIHFHTLAYHILATVDGHWANQL AAVAAGARVAGTQACATETIDTRRVSLKAPHEFMTSRLEAGSKVVLNPSEPVVAWHREGVSFHFTPVLVCKDPVRTVGLG DAISAEGLFYSEVHPHL >XP_018108378.1 ADP-dependent glucokinase isoform X1 [Xenopus laevis] MWPKAVCVGLLAISLGLLHHLHPEISDAALDYLSSSLQSIASREPASSSPPIEEAFSAAWDRLIVAPSKHWERVAVGVNA CVDVVLSGIGLLQALALTPQSSEDHMVLNTQEDLAETFLHYMQQGAAAERFYSDAKSFAHISRTASQDPRAQHFVGGNAA LIAQRLAANPDMEVLLCGPVGPKLHELLDERVFVPPTSLQEEDEYHLILEYKSGEQWGSRQAPAASRFIFSHDLSNGAMT SLEVLLSSLEVFQPKLLVLSGLHMMEGLSREAREERLREAAASLSEVPSDILIHLELASMTDGDLMRGIIYQQVFPFISS LGLNEQELLFLSHSASGPHASISAWSGIPEVGIVSDILFWILKGSKNEASSLTRIHFHTLAYHILATIDGFWGNQVSAVA AGARVAGTQACASETIDATRVKLKTPLEFSTSREQVGSTVRVSAQEPVAVWIREGVTFHFTPVLICKEPVRTVGLGDAIS AEGLLFSEATSQ >XP_038076901.1 ADP-dependent glucokinase-like [Patiria miniata] MEWGPLILAFALIAAAYLYGFNLKSTNTEPNVRQVTSAESQVLQGWDQQIQEPAERVKRVAVGLNVNADLIVSATSLLDK LGIQPAVSQDHTLLNSLKDLQESFAFFFESGAAAERYFANGEVYKRIIEEADKLEQKEYSVGGNAALMAYKMAELTDDVQ ILLIGPIGPKVHSLMPSSVNIHETSLRDTDEVHLIMEYAKGEKWGALTTPIATRFITSHDVANAELDGLNVFSSSVKEFN PDVVMFSGLHLLDSSSQSEQQNKLSALVTELKKLPKSLPLHLELASMANEGLVQFIVAQVLSSVHSLGLNEQELGLVSRA NNGPHPDITAEESGYIEIGAVADILYWILTSLVKGQSSLLTRVHFHSLTFHVVATLPNQWDNSVSAVGVGARIAGRQACG DVPIQPSKVTLRIPKAFPLSADYAPLRKTVVIVDPSNPLMTWKRGQVTFHFSPVLVCKKPGKTVGLGDAISATAMLYTQY MQRL >XP_793568.3 ADP-dependent glucokinase [Strongylocentrotus purpuratus] MFSNTFVIGVVLIAVSLYYSVHFNHDRSAISVESQIAIAWGNVIAAGFSLHGLRNKSRIAVGVNVNTDLIVSGTAVLKKL GIDSSGQAIDNAVIESLEELEQTFAFSLKNGAAIERIFSRSEDFEKVVQAADSLDEKQYFVGGNAALAGLKMADTWKGLE VLLIGPCGPRVRALLPPNIIVPKPSYKETDEVHLIMEFKRNERWGDYEAKVATRFISSYDVSNTEMSALSEFSRSVTDFS PDAVFFSGLHLLDGQPGVKKEEKMAALNQELSRLPSDLPVHLELASMADPELIKGIYTQVLSSVHSLGLNEQELSFMSSV NSGPHPEVYIRDGYPEVGAVADILYWILTSTQQGSWLTKAEQSSAAGWSSTLTRVHFHSLAFHIVATMNGTWINNAAAVS AGARIAGRQACDDGRIVDEKVELRVPQAFALSINHAPLRHRIVSVDPQNPVISWTRDNIQFHFTPVLVCKNPVKTVGLGD AISSTGFLFSQMVSSS >XP_039273116.1 ADP-dependent glucokinase-like [Styela clava] MEFTWRKALFICCMAGGILWFSNPISDYFFDYLADPNEMEIIIAKSWNKTIDSPKPENMKFHAIAIGINAGIDIIVKGTD LLKKLGTDEKEESTIKATDRESINNLRQLQEVFTYFHSKGAGGERFMNNKELFAKAVGMSKAMPGAELYVGGNAALMAQA IVQASAKNVHVLFGGMVGPGLSPMLNRRLIVPSKLKAEEDEYHIILEYVKGEKWAGHVCPIASRFIFSHDLTNSRMLASE KFIDSLKEFNPDMVVLTGLHLLEGQPEAYWKRRLAEIAASLAKVSTNVPIHTELASMANPAFVKALTERILPMVDSIGLN EQELWMTCQANGGPHCKPEYELDGPPSPGVSNDIIHWMLQQFSKRRIPSSRLSRVHFHTLVYHTVATLDSSKWRYGDSSV AAGARIASTQSCGVHSVHPAKVELRLKSTIPLTAGGLPENVEQPKDTRLDYSNPIISWKTSKISFFMTPVLVCQNPVKTV GLGDAISSMGLLHSGYDK >NP_493657.2 putative ADP-dependent glucokinase [Caenorhabditis elegans] MFSETFVPSIFSYKHRLLHLSVLFFIVPYWYSYYNDQHRLSSYSVETAMFLSWERAIVKPGAMFKKAVIGFNCNVDLIVS GVRVVDALNTTCSEGKDQETLETLADLHQTFAHFFQRGAAAERYMSSEDQFNLLVAESEASTRSHHHIGGNAALMADRIA ANFPSTEVYLVGPIGPRSQALLHPSVKRTNSTRILKDELHVILEYKQGEILGDWVAPSSSRFITSHDHFSGSMVVMEMFF KAIAQFRPDLVVITGVHLLEFQSKEMRQEKMRLIKRNLLQIPPKVPIHLELGSLADEIFSTDVINKILPYVDSLGINEQE LTFLSHIANGPHMEEYPVQAGTVHVHKVVEMLHWLLKTYGRDPTGQIASKTGYRLSRIHFHCLTYHIMVSSGTDWSNLAA GLAAGARIAGRLSCNIGANTMDSELLEIRTPANFVLDKKIEKNYQFEAHNPIASWMREDVLFVFTPVLVCRLPSKTVGID DAISATGLLYSQFYRLNRPTHW >OWK09674.1 ADPGK [Cervus elaphus hippelaphus] MALWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRPARRWRRVAVGVN ACVDVVLSGVKLLRALGLSPGNGRDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPEAQSFCFSGR SISPVETGSGRLSTSLLVFALRKHIFVHMSHI >CAE1165978.1 ADPGK [Sepia pharaonis] MIENNVPEVEYYLRSFLLFTKLFEKLDYSPPTKVRHHSSLQTPEQLQELFAYFFQFGAAAERYVNNDTFFEELWKNANSI KGRQWFLGGNALSMAQRLVQEGAEVLLGMSHSKKLRALLPPEVKVAGPNLVTDDIHLILEYNKGDNWGSFTSPRANRLIL HSDNSNPQLEALENFQEQLDSFQPSLLVLGGLQMMDNFPYEPGERTGRLNKVQEMLSSLPRKTKVHFEFASFTDMDLLHE IMAKVIIYADSIGLNEQELPNLVTLLNDGSVTVVSDSYPRIATVLDQMRFVYSHLQNSSELEGRRRLTRLHVHTIAFQAI LTDKSSTWKNSMSATAKAALTAHRHVCGSADIDTLKARILMDDSFSTSKLKSAQRIPLQKNRPVSCWDEDRFQICIAPVL VCTKVQQTAGGGDNISSAGLVLQV >NP_001246747.1 uncharacterized protein Dmel_CG6650, isoform B [Drosophila melanogaster] MTALRYMGWITGCSVLTAFVSIIWQAFIALQTLNRTTVLLTGLLAIEGSLKRTALEPAPKVAIGYGACTDLQINATEFLD RYYGRRIPVAAATTGSRAVVNNEDELLQSFAYYFQNGAAAERVMANSTLFTQLVGYAKVMDKERINWYMGGNAPLMAVRF FMEGAQVLLGAHMSRKLRPLLPKEIRLAGDEIPNDDIHLILEYKAGDKWGPYVAPRANRYILHNDRNNPHLRAVEQLTDA LKMYQPQLLVVSGLQMMDMFTFKSGEREARLQQVQRQLTSQPQGTLNHFEMASYVELQLLQQLRHFVLPYVDSLGMNEQE LSNLQQVLAHGRTTLATDWNPRIAHTLDQMRQVFISLLEDYEDRSSSDAKRRSISRIHVHTLAYQAILTTAGSKWKNTRA AAAKAALTAHRYVCKSQFINPEAVLQVLDDSFATSAQADAPRMRIGAASPVPCWREYIQYGRHRQRLEVEICVAPVLVCR EARKTAGAGDNISASGLAAQL >KAG9435874.1 ADP-dependent glucokinase [Apis mellifera carnica] MVYVLMYINAKDLLNYSEKIGQPQHFDEINTELELLKSFAYYFRHGAAAERYMANRTLFDELVTKARSFPSSYTTIGGNA AIMALRFAREGCDVTLAAKLTRSLHQMIPQVINIVGGEVKRDDIHLVIEYKHGDIWGPYSSARANRYIIHNDANNPRISS LDAFDNLLLMYEPNLLVISGLQMMDNYPFPEGDRQKLLHKIKKQMMNRSVSTKIHFEMASFAEDKFLFELCDSIIPYADS LGMNEQEIANLHNAMYYGNISLVANSTPRIATVLDQMRTLFKLIRMRSKTIENSRELTRIHVHTLAYQAIFTVKSSIWKN TMAAAAKASLTAHRHVCATSYVDIKKAALILDDSFSTSIVDGTRIALDIDKPVSCWDEILKIGNKDIPIQVCVAPVLVCT EAAQTAGGGDNISSAGLVLQI >XP_031571788.1 ADP-dependent glucokinase-like [Actinia tenebrosa] MASSYGVVAVLVLIAALFAGYYYRKISHEKHLRSIMDGMLALERNHSVTHSPVAVLAFESTMDVFADSFELLKALGIEPP QKAFPHEVIDSETALAETFAYFFEHSVASSKYVANKELFRKMAEKANNLQSTKFIIGGTAIAFAKRLTVERWRTHLAVLM TESTKKHLPDDITVAGSVPEDDDIHLILEFPGFENWGDKFVSQRSNRMVLHSDINNPYLKSLEDLKAVTKREEPNIVIIG GLHMLDNFPFKDGERGERLGELAKYLSALSPQVLVHFEMGVFHEHALFVDLLEYVFPYSDSLGMNEQDLPNLLTMLKDNK ITKTATQKPRVAAILDQMRQVYKLLRAKPLGNGKRKVTRLHLHTLAFQVMMTTKDSSWKNTQAATAKASLTATRYICGSN FIHTNKTRLIMDESFSLSTYPGSDRMPLNADNPVPCWDEEDYEFCVTPVLVCTDIVHTAGGGDNVSGAGLTLQV >NP_001352154.1 ADP-dependent glucokinase isoform 4 precursor [Homo sapiens] MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRPVR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFH DIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLIL EYQAGEEWGQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLE VVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVP DVGMVSDILFWILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFY SEVHPHY >NP_001094193.1 ADP-dependent glucokinase precursor [Rattus norvegicus] MALWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPPGSLSPESRLAAAWDALIVQPAR RWRRVAVGVNACVDVVISGVKLLQALGLSPGSGRDHAVLHSRSDLEEAFVHFMGKGAAAERFFSDRETFH DIAQAASEFPGAQHYVGGNAALIGQKFAANPDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLIL EYLAGEEWGPFKAPQANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLE VVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVASLGLNEQELLFLSQSASGPHASLSSWDGVP DVGMVSDILFWILKEHGRSKSRSSDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTNRVSLRAPQEFMTSRLEPGSRIVLNPNKPVVEWHREGVTFHFTPVLVCKDPVRTVGLGDAISAEGLFY SEAYPD >XP_004943715.1 ADP-dependent glucokinase isoform X1 [Gallus gallus] MWQRSVCVGLLALALGYLCLLGPQLPPSVLQHLSASLLGGLSRAGSLESRMVAAWQAAIVRPARGWGRVA VGVNACVDVVLSGVKLLEALGLKPGSGKNHDVLNSRQDLREAFTHFMEKGAAAERFFSDAESFHHIAQTA SEHPGAQLYVGGNAALIGQKLAANPDLKILLCGPVGPKLHELLDDSVVVPPESMQERDEFHLILEYQAGE EWGQVKAPNANRFIFSHDLSNGALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEMRHRRLMEAVASIS DIPTDIPIHLELASMTDQDFMSNIVHQQVFPLVNSIGLNEQELLFLTQSASGPHASLASWNGVPDVGAVS DILFWILKEHGKIADRASDLTRIHFHTLAYHILATVDGHWGNQVAAVAAGARAAGVQACATETIDTSKVF LKAPLEFVTSQIDAPSKISLNPDEPVVHWHREGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEIYLQ >XP_005638630.1 ADP-dependent glucokinase isoform X1 [Canis lupus familiaris] MALWRGSAYAGFLALAVGCVLLLEPQLPGSALRSLWSSLQLAPAPPGPGSPEGRLAAAWDALIVRPARRW RRVAVGVNACVDVVLSGVKLLQALGLNPGNGKDHSILHSRTDLEEAFVHFMGKGAAAERFFSDKEAFQDI AQMASELPGAQHYVGGNAALIGQKFAANSELKVLLCGPVGPKLHELLDDNVFVPPESLQEMDEFHLILEY QAGEEWGRLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVV TSISDIPTGVPVHLELASMTNRELMRSIVHQQVFPAVTSLGLNEQELLFLSQAASGPHSSLSSWNGVPDV GMVSDILFWILKEHGRSKGRASDLTRIHFHTLVYHILATIDGHWANQLAAVAAGARVAGTQACATEAIDA SRVSLRAPPEFMTSRSEAGARIVINPNEPVAEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSE ARPHS >NP_001075907.1 ADP-dependent glucokinase precursor [Bos taurus] MALWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGVGSPEGRLAAAWDALIVRPAR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSELHSRNDLEEAFVHFMGKGAAAERFFSDKETFH DIAQVASEFPEAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLIL EYQAGEEWDQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLE VVTSISDIPTGVPVHLELASMTNKELMSTIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVP DVGVVSDILFWILKEHGKSESRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAATQACATETI DTRRVSLKAPHEFMTSRLEAGSRVVLNPNEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFY SEVHPHL >NP_001073434.1 ADP-dependent glucokinase precursor [Danio rerio] MWRKAVLVAVLALGMGYLYHTDPELPARMLSYVSQSLPPMEAGGGSEPRPPTLEEAIARAWQTLITAPAR RWGRVAVGVNACVDVVVSGVGLLQALALEPGSGRDHEVLHSKEDLKEAFIHYMGKGAAAERFFSDKEVFQ RIARAAAEYPGAQLYVGGNAALIGQKLASNPQLVVLLCGPVGPKLHEMLDEQIVVPPESLQETDEYHLIL EYKSGEQWGPSRAPQANRFILSHDVSNGEMSALEMFVASLEEFQPDLVVLSGLHMMEGMGRELWEERLKE AVVAISDVRNEVPIHLELASMTDRDYMNRILQEQVMPIVNSIGLNEQELLFLTQSGGGPHSDLTSWDGVP DVGRVTDILLWVLEQHGRADAQSEADLTRIHFHTLAYHILATVDGHWGNQAAAVAAGARVASSQACGLQT IDISKVLLKAPLNFHSSFSEPRESLKVEPSRPVTVWRRGNVSFHLTPVLVCKQPLRTVGLGDAISAEGLV FSELTSEV >XP_016782646.1 ADP-dependent glucokinase isoform X1 [Pan troglodytes] MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRPVR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFH DIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLIL EYQAGEEWGQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLE VVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVP DVGMVSDILFWILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFY SEVHPHY >XP_002825682.1 ADP-dependent glucokinase isoform X1 [Pongo abelii] MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAATWDALIVRPVR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFH DIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPSESLQEVDEFHLIL EYQAGEEWGQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLE VVTSISDIPAGIPVHLELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVP DVGMVSDILFWILKEHGRSKSRVSDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCRDPIRTVGLGDAISAEGLFY SEVHPHY >XP_017194042.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Oryctolagus cuniculus] MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLRLGPAPAALGPASPESRLAAAWDALIVQPAR RWRRVAVGVNACVDVVLSGVRLLQALGLRPGPGRDHAVLHSRNDLEEAFVHFMGRGAAAERFFSDKEAFQ DIAQVASALPAAQHYVGGNAALIGQKFAANTDLKVLLCGPVGPKLHDLLDDNVFVPPESLQEVDEFHLIL EYQAGEEWGQLKAPHANRFIFSHDLSNGAMNALEVFVSSLEEFQPDLVVLSGLHMMEGQSTELQRRRLLE VVTSISDIPTGVPVHLELASMTNRELMSSIVHQQVLPAVASLGLNEQELLFLSQSASGPHSSLSSWNGVP DVGVVSDILFWILKEHGRSESRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAATQACATETI DASRVSLRAPQEFVTSRLEVGSRIVLNPREPVVAWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFY SEVHPRS >XP_010715462.1 ADP-dependent glucokinase isoform X1 [Meleagris gallopavo] MWQRSACVGLLALALGYLWLLGPQPSPSILQHLSASLLGGLSRAGSLESRMVAAWQAAIVRPARGWGRVA VGVNACVDVVLSGVKLLEALGLKPGLGKNHDVLNSRQDLREAFTHFMEKGAAAERFFSDAESFHHIAQTA SEHPGAQLYVGGNAALIGQKLAANPDLKILLCGPVGPKLHELLDDNVVVPPESMQERDEFHLILEYQAGE EWGQVKAPNANRFIFSHDLSNGALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEMRHRRLMEAVASIS DIPTDIPIHLELASMTDQDFMSNIVHQQVFPLVNSIGLNEQELLFLTQSASGPHASLASWNGVPDVGAVS DILFWILKEHGKTADRASDLTRIHFHTLAYHILATVDGHWGNQVAAVAAGARAAGAQACATETIDTSRVF LKAPLEFVTSQIEAPSKISLNPDEPVVHWHREGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEINLQ >XP_020954758.1 ADP-dependent glucokinase isoform X1 [Sus scrofa] MALWRGSVYAGFFALAVGCVFLLEPQLPGSALRSLWNSLQLGPVPSPLGPGSPEGRLAAAWDALIVRPAR SWRRVAVGVNACVDVVLSGVKLLQALGLNPGTGKDHTELHSRNDLEEAFIHFMGKGAAAERFFSDKESFH DIAQIASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEMDEFHLIL EYQAGEEWGQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLE VVASISDIPTGIPVHLELASMTNRELMGSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSAWTGVP DVGMVSDILFWILKEHGRSESRASDLTRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATATI DTHRVSLRAPLEFVTSRSEAGSRIVLNPNEPVVEWHREGVSFHFSPVLVCKDPVRTVGLGDAISAEGLFY SEVHPHH >XP_003818615.1 ADP-dependent glucokinase isoform X1 [Pan paniscus] MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRPVR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFH DIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLIL EYQAGEEWGQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLE VVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVP DVGMVSDILFWILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFY SEVHPHY >XP_023110850.1 ADP-dependent glucokinase [Felis catus] MALWRGSAYAGFLALAVGCVLLLEPQLPGSALRSLWSSLQLAPAPPGPGSPEGRLAAAWDALIVRPARRW RRVAVGVNACVDVVLSGVKLLEALGLSPGNGKDHTILHSRNDLEEAFIHFMGKGVAAERFFSDEEAFHDI AQIASELPRSPGLFGSPHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEF HLILEYQAGEEWGRLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRK RLLEVVTSISDIPTGIPVHLELASMTNRELMRSIVHQVFPAVTSLGLNEQELLFLSQAASGPHSSLSSWN GVPDVGMVSDILFWILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACAT ETIDASRVSLRAPREFMTSHSEAGSRIVIDPSRPVAEWHREGVSFHFTPVLVCKDPIRTVGLGDAISAEG LFYSEARPHY >XP_027827363.1 ADP-dependent glucokinase isoform X1 [Ovis aries] MALWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRPAR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSELHSRNDLEEAFVHFMGKGAAAERFFSDKETFH DIAQVASEFPEAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLIL EYQAGEEWDQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLE VVTSISDIPTGVPVHLELASMTNKELMSSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVP DVGVVSDILFWILKEHGKSESRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTRRVSLKAPHEFTTSRLEAGSRVVLNPNEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFY SEVHPHS >XP_018866672.2 ADP-dependent glucokinase isoform X1 [Gorilla gorilla gorilla] MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRPVR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFQ DIAQVASEFPGAQHYVGGNAALIGQKFAAYSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLIL EYQAGEEWGQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLE VVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVP DVGMVSDILFWILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLVY SEVHPHY >XP_004069514.1 ADP-dependent glucokinase isoform X1 [Oryzias latipes] MWRKASAAVLLALAVGYFYSGSPELPERVLQYFNQASPGNGLEHAISAAWEALITLPSRQWSKVAVGVNA CVDVVVSGVGLLQALAVDPGAGRDHEVLHSKEDLKEAFIHFMERGAAAERFFSDEEVFQQIARAAAEYPG AKLYVGGNAALMGQKFATYPDLMVLLCGPIGPKLHELLDEQIHVPPESLQEIDEFHLILEYKAGERWGST QAPQANRFIFSHDVSNGGMSSLETFVASLEEFQPELVVLSGLHMMEGRGRELWDGRLKQAVMALADIPKD IPIHLELASMTDKDFMNSIMQEQVMPIVSSIGLNEQELLFLSQAGGGPHAALPAWTGVPEVGRVSDILLW ILERHGRVEPSSESELTRIHFHTLAYHILAMVDGYWGNQAAAVMAGARVASSQACGLQAVDPSKVELKAP LEFYSSHSEPREKLSLDPTEPVAVWRRGNVTFHFTPVLVCKHPLRTVGLGDAISAEGLVYSELKIQQAF >XP_021156443.1 ADP-dependent glucokinase isoform X1 [Columba livia] MHQNNSLLCNKSTSKGERFSREFQQVNVMLGFFFCILLVVFSLSTRAAKSKRRWLGRDRLVEKVRVVFPV CVLPCSSVNACVDVVLSGVKLLEALGLEPGDGKNHAVLTSGQDLREAFAHFMEKGAAAERFFSDADAFHR IARAAAEHPGAQLYVRGNAALIGQKLATNPELKILLCGPVGPKLHELLDDNVVVPPESMQERDEFHLILE YQAGEEWGRVRAPNANRFIFSHDLSNGALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEARQRRLMEA VASISDIPTDIPIHLELASMTDQDFMSNIVHQQVFPLVNSLGLNEQELLFLTQAAAGPHASLAAWSGVPD VGVVSDILFWILKEHGKTAERASDLTRIHFHTLAYHILVTVDGYWGNQAAAVAAGARAAGTQACATDTID TSKVFLKAPLEFVTSQLEAPAKISLNPDEPVVRWHREGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYS EVYPQ >XP_017910167.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Capra hircus] MALWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRPAR RWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSELHSRNDLEEAFVHFMGKGAAAERFFSDKETFH DIAQVASEFPEAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLIL EYQAGEEWDQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLE VVTSISDIPTGVPVHLELASMTNKELMSSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVP DVGVVSDILFWILKEHGKSESRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETI DTRRVSLKAPHEFTTSRLEAGSRVVLNPNEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFY SEVHPHS >XP_025050700.1 ADP-dependent glucokinase [Alligator sinensis] MRKKGPLEQGCKERVNACVDVVLSGVKLLQALGLDPGNGEDHAVLNSKKDLKEAFSHFMQKGAAAERFFS DAVSFHHIAQAASEYPGAQLYVGGNAALIGQKLATNPHLKVLLCGPVGPKLHELLDDNVIVPPESMQETD EFHLILEYQAGEEWGQTRAPNANRFIFSHDLSNGAMNMLEVFVASLDEFQPDLVVLSGLHMMEGQSKEMR AKRLLAAVTSLSDIPTDIPIHLELASMTDQDLMSKIMLQQVFPLVNSIGLNEQELLFLTQSAAGPHASLT SWNGVPDVGIVSDILFWILKEHGRTTDKLSDLTRIHFHTLAYHVLATVDGYWGNQIAAVAAGARVAGTQA CATETIDTDKVSLKAPLEFVTSQTETNTKISLNPGEPVAHWQREGISFHFTPVLVCKDPIRTVGLGDAIS AEGLLYSEIYPQ >XP_015830283.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Nothobranchius furzeri] MWRTASAAVLLALAVGYFYHGRPDLPEQILQYVGLPHLQTSSQSQKSLEHVVSAAWEALITLPAHQWSKV AVGVNACVDVVVSGVGLLQALAVDPGTGLDHEVLHSKEDLKETFIHFMERGAAAERFFSDSEVFQRIARA AAEYPGAKLYVGGNAALIGQKFASYPDLMVLLCGPVGPKLHELLDEQIVVPPGSLQETDEFHLILEYKAG ERWGSTQAPQANRFIFSHDVSNGGMSSLEMFVASLEEFQPELVVLSGLHMMEGQGRELWKERLKQAVASI AEIPKDIPVHLELASMTDKDFMISIVQEQVMPMVSSMGLNEQELLFLSQAAGGPHSALPAWKGIPDVGRV SDILLWILEHHGRGAISSESDLTRIHFHTLAYHILATVGGHWGNQAAAVMAGARVASSQACGLRVVDVEK VELKAPLEFYSSHSEPRDHLSLNPAEPVMVWHRGNVTFHMSPVLVCKHPLRTVGLGDAISAEGLYYSQFK GEQHL >XP_020749492.1 ADP-dependent glucokinase isoform X1 [Odocoileus virginianus texanus] MCLTEQFHGKGADLLIDSMLLLQVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDQL KAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGHSKEFQRKRLLEVVTSISDIPAG VPVHLELASMTNKELMSSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFW ILKEHGKSESRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETIDMRRVSLKAPH EFMTSRLEAGSRVVLNPSEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHS >XP_030282616.1 ADP-dependent glucokinase isoform X1 [Sparus aurata] MWRKASVAALLALAVGYLYYGGPELSEQILQYISLPNIQSPSQNSPNSQKSVEQLISAAWETLITLPTRQ WSKVAVGVNACVDVVVSGVGLLQALAVDPGVGLDHEVLHSKEDLREAFIHYMERGAAAERFFSNKEVFQR IARAAAEYPGAKLYVGGNAALIGQKLATYPDLMVLLCGPVGPKLHEMLDEQIVVPPESLQETDEYHLILE YKAGEQWGSVQAPQANRFIFSHDVSNGAMSSLETFVASLDDFQPELVVLSGLHMMEGQGRQLWEERLKEA VSAISDIRRDVPIHLELASMTDKDYMNSIMQEQVMPIVSSIGLNEQELLFLSQAGEGPHSDMATWKGIPD MGRVSDILLWILEQHGRSDPSSEADLTRIHFHTLAYHILATVDGYWGNQAAAVMAGARVASSQSCGLQSV DVSKVELKAPLDFHSSHAEPREKLSLNPAEPVTVWQRGNVTFHMTPVLVCKQPLRTVGLGDAISAEGLIY SELKTQQPI >XP_040198962.1 ADP-dependent glucokinase isoform X1 [Rana temporaria] MWVKVCVGLMAMAVGLLHHLQPNLLEAAQDYFSSSLQSISPGVTPSHPSLEEALSTTWDTLITAPAKHWG KVAVGVNACVDVVVSGVSLLKALGLSPQPGGDHLVLNAQEELAETFQHYMQRGAAAERFYSDADSFQHIS RTASQEPGAKHFVGGNAALIAQRLATHPDLEVLLCGPIGPKLHELLDERIVVPPASLKDQDEYHLILEYK AGEKWGSGQAPAASRFIFSHDLSNGAMTSLEVLLSSLEEFQPKLLVLSGLHMMEGLSQEARANRLQEAAT ALSDVPSDILIHLELASMTDGDLMRGIIHQQVFPVISSVGLNEQELLFLSQSSSGPHSALPAWSGIPDVG IVSDILFWILKGSVRGDSALTRVHFHTLAYHILATVDDFWGNQVAAVAAGARIAGAQACASEIIEPSKVM LKSPLEFSTSKTDMGPTARVSAKEPVAVWRKDGVTFHFTPVLICKEPVRTVGLGDAISAEGLLFSEAKTQ
Mafft alignment of selected proteins >NP_082397.1 ADP-dependent glucokinase isoform 1 precursor [Mus musculus] MA----------LWRGSACAGFLA-LAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPV- --GPLSPESRLAAAWDALIA-------QPA---RRW-------RRVAV----------GV NACVDVVISGVKLLQ-----ALGLSPG-----SGKDHAILHSRSDLEEAFLYFMGKGAAA ERFFSDKETFHDIAQAASEFP------GAQ--HYVGGNAALIGQRF--AA-NTDLKVLLC GPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEWG-PFKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTAISDIPTGIPVH LELASMTNRELMSSIVHQQVFPTVASLGLNEQELLFLSQSASGPHASLS-SWDGVPDVGM VSDILFWILKEH----GRSE-----------NRASDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTNRVSLRAPQEFTTS------HLESGSR---IVLN PDKPVVEWHR----------EGITFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEARPD- ----- >KAB0375010.1 hypothetical protein FD755_013502 [Muntiacus reevesi] MA----------LWRGSAYAGFLA-LAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPP- --GAGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLR-----ALGLSPG-----NGKDHSELRSRNDLEEAFVHFMGKGAAA ERFFSDKETFHDIAQIASEFP------EAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWD-ELKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEF--QRKRLLEVVTSLSDIPTGVPVH LELASMTNKELMSNIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GKSE-----------SRASDLSRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTRRVSLKAPHEFMTS------RLEAGSR---VVLN PSEPVVAWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHL ----- >KAB0342610.1 hypothetical protein FD754_019536 [Muntiacus muntjak] MA----------LWRGSAYAGFLA-LAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPP- --GAGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLR-----ALGLSPG-----NGKDHSELRSRNDLEEAFVHFMGKGAAA ERFFSDKETFHDIAQIASEFP------EAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWD-ELKAPHANRFIFSHDLSN GAMSMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEF--QRKRLLEVVTSLSDIPTGVPVH LELASMTNKELMSNIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GKSE-----------SRASDLSRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTRRVSLKAPHEFMTS------RLEAGSR---VVLN PSEPVVAWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHL ----- >XP_043326947.1 ADP-dependent glucokinase isoform X1 [Cervus canadensis] MA----------LWRGSAYAGFLA-LAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPP- --GAGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLR-----ALGLSPG-----NGRDHSELRSRNDLEEAFVHFMGKGAAA ERFFSDKETFHDIAQIASEFP------EAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWD-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEF--QRKRLLEVVTSLSDIPMGVPVH LELASMTNKELMSNIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GKSE-----------SRASDLSRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTRRVSLKAPHEFMTS------RLEAGSK---VVLN PSEPVVAWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHL ----- >XP_018108378.1 ADP-dependent glucokinase isoform X1 [Xenopus laevis] ------------MWPKAVCVGLLA-ISLGLLHHLHPEISDAALDYLSSSLQSIASREPA- S-SSPPIEEAFSAAWDRLIV-------APS---KHW-------ERVAV----------GV NACVDVVLSGIGLLQ-----ALALTPQ-----SSEDHMVLNTQEDLAETFLHYMQQGAAA ERFYSDAKSFAHISRTASQDP------RAQ--HFVGGNAALIAQRL--AA-NPDMEVLLC GPVGPKLHELLDERVFVPPTSLQEEDEYHLILEYKSGEQWG-SRQAPAASRFIFSHDLSN GAMTSLEVLLSSLEVFQPKLLVLSGLHMMEGLSREA--REERLREAAASLSEVPSDILIH LELASMTDGDLMRGIIYQQVFPFISSLGLNEQELLFLSHSASGPHASIS-AWSGIPEVGI VSDILFWILKGS----K--------------NEASSLTRIHFHTLAYHILATID-GFWGN QVSAVAAGARVAGTQAC--ASETIDATRVKLKTPLEFSTS------REQVGST---VRVS AQEPVAVWIR----------EGVTFHFTPVLICKEPVRTVGLGDAISAEGLLFSEATSQ- ----- >XP_038076901.1 ADP-dependent glucokinase-like [Patiria miniata] ------------MEWGPLILAFAL-IAAAYLYGFNLKSTNT-------------EPNVR- --QVTSAESQVLQGWDQQIQ-------EPA---ERV-------KRVAV----------GL NVNADLIVSATSLLD-----KLGIQPA-----VSQDHTLLNSLKDLQESFAFFFESGAAA ERYFANGEVYKRIIEEADKLE------QKE--YSVGGNAALMAYKM--AELTDDVQILLI GPIGPKVHSLMPSSVNIHETSLRDTDEVHLIMEYAKGEKWG-ALTTPIATRFITSHDVAN AELDGLNVFSSSVKEFNPDVVMFSGLHLLDSSSQSE--QQNKLSALVTELKKLPKSLPLH LELASMANEGLVQFIV-AQVLSSVHSLGLNEQELGLVSRANNGPHPDITAEESGYIEIGA VADILYWILTSL----VKGQ-------------SSLLTRVHFHSLTFHVVATLP-NQWDN SVSAVGVGARIAGRQAC--GDVPIQPSKVTLRIPKAFPLS------ADYAPLRKTVVIVD PSNPLMTWKR----------GQVTFHFSPVLVCKKPGKTVGLGDAISATAMLYTQYMQRL ----- >XP_793568.3 ADP-dependent glucokinase [Strongylocentrotus purpuratus] ------------MFSNTFVIGVVL-IAVSLYYSVHFNHDR-------------------- --SAISVESQIAIAWGNVIAAGFSL--HGL---RNK-------SRIAV----------GV NVNTDLIVSGTAVLK-----KLGIDSS----GQAIDNAVIESLEELEQTFAFSLKNGAAI ERIFSRSEDFEKVVQAADSLD------EKQ--YFVGGNAALAGLKM--ADTWKGLEVLLI GPCGPRVRALLPPNIIVPKPSYKETDEVHLIMEFKRNERWG-DYEAKVATRFISSYDVSN TEMSALSEFSRSVTDFSPDAVFFSGLHLLDGQPGVK--KEEKMAALNQELSRLPSDLPVH LELASMADPELIKGIY-TQVLSSVHSLGLNEQELSFMSSVNSGPHPEVY-IRDGYPEVGA VADILYWILTST----QQGSWLTKAEQSSAAGWSSTLTRVHFHSLAFHIVATMN-GTWIN NAAAVSAGARIAGRQAC--DDGRIVDEKVELRVPQAFALS------INHAPLRHRIVSVD PQNPVISWTR----------DNIQFHFTPVLVCKNPVKTVGLGDAISSTGFLFSQMVSSS ----- >XP_039273116.1 ADP-dependent glucokinase-like [Styela clava] ME---------FTWRKALFI--CC-MAGGILWFSNP-ISDYFFDYLA------------- --DPNEMEIIIAKSWNKTID-------SPKPENMKF-------HAIAI----------GI NAGIDIIVKGTDLLK-----KLGTDEKEESTIKATDRESINNLRQLQEVFTYFHSKGAGG ERFMNNKELFAKAVGMSKAMP------GAE--LYVGGNAALMAQAIVQAS-AKNVHVLFG GMVGPGLSPMLNRRLIVPSKLKAEEDEYHIILEYVKGEKWA-GHVCPIASRFIFSHDLTN SRMLASEKFIDSLKEFNPDMVVLTGLHLLEGQPEAY--WKRRLAEIAASLAKVSTNVPIH TELASMANPAFVKALT-ERILPMVDSIGLNEQELWMTCQANGGPHCKPEYELDGPPSPGV SNDIIHWMLQQF----SKRR-----------IPSSRLSRVHFHTLVYHTVATLDSSKWRY GDSSVAAGARIASTQSC--GVHSVHPAKVELRLKSTIPLTAGGLPENVEQPKD---TRLD YSNPIISWKT----------SKISFFMTPVLVCQNPVKTVGLGDAISSMGLLHSGYDK-- ----- >NP_493657.2 putative ADP-dependent glucokinase [Caenorhabditis elegans] MFSETFVPSIFSYKHRLLHLSVLF-FIVPYWYSYYNDQHRL------------------- --SSYSVETAMFLSWERAIV-------KPG---AMF-------KKAVI----------GF NCNVDLIVSGVRVVD-----ALNTTCS-----EGKDQETLETLADLHQTFAHFFQRGAAA ERYMSSEDQFNLLVAESEAST------RSH--HHIGGNAALMADRI--AANFPSTEVYLV GPIGPRSQALLHPSVKRTNSTRILKDELHVILEYKQGEILG-DWVAPSSSRFITSHDHFS GSMVVMEMFFKAIAQFRPDLVVITGVHLLEFQSKEM--RQEKMRLIKRNLLQIPPKVPIH LELGSLADEIFSTDVI-NKILPYVDSLGINEQELTFLSHIANGPHMEEYPVQAGTVHVHK VVEMLHWLLKTY----GRDP---TGQ--IASKTGYRLSRIHFHCLTYHIMVSSG-TDWSN LAAGLAAGARIAGRLSCNIGANTMDSELLEIRTPANFVLD-------KKIEKN---YQFE AHNPIASWMR----------EDVLFVFTPVLVCRLPSKTVGIDDAISATGLLYSQFYRLN RPTHW >OWK09674.1 ADPGK [Cervus elaphus hippelaphus] MA----------LWRGSAYAGFLA-LAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPP- --GAGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLR-----ALGLSPG-----NGRDHSELRSRNDLEEAFVHFMGKGAAA ERFFSDKETFHDIAQIASEFP------EAQ--SF-------------------------- ------------------------------------------------------------ ---------------------CFSG----------------------------------- -----------------RSISPVETGSG------------------RLS----------- -TSLLVFALRKH------------------------------------------------ ------------------------------------------------------------ ----------------------IFVHMSHI------------------------------ ----- >CAE1165978.1 ADPGK [Sepia pharaonis] MI---------------------------------------------------------- -------------------------------------------ENNVP----------EV EYYLRSFLLFTKLFE-----KLDYSPP----TKVRHHSSLQTPEQLQELFAYFFQFGAAA ERYVNNDTFFEELWKNANSIK------GRQ--WFLGGNALSMAQRL--VQ--EGAEVLLG MSHSKKLRALLPPEVKVAGPNLV-TDDIHLILEYNKGDNWG-SFTSPRANRLILHSDNSN PQLEALENFQEQLDSFQPSLLVLGGLQMMDNFPYEPGERTGRLNKVQEMLSSLPRKTKVH FEFASFTDMDLLHEIM-AKVIIYADSIGLNEQELPNLVTLLNDGSVTVV--SDSYPRIAT VLDQMRFVYSHL-----QNS--------SELEGRRRLTRLHVHTIAFQAILTDKSSTWKN SMSATAKAALTAHRHVC--GSADIDTLKARILMDDSFSTS------KLKSAQR---IPLQ KNRPVSCWDE----------DRFQICIAPVLVCTKVQQTAGGGDNISSAGLVLQV----- ----- >NP_001246747.1 uncharacterized protein Dmel_CG6650, isoform B [Drosophila melanogaster] MTALRYMG---WITGCSVLTAFVSIIWQAF------------------------------ --IALQTLNRTTVLLTGLLAIEGSLKRTAL---EPA-------PKVAI----------GY GACTDLQINATEFLDRYYGRRIPVAAA-----TTGSRAVVNNEDELLQSFAYYFQNGAAA ERVMANSTLFTQLVGYAKVMD------KERINWYMGGNAPLMAVRF--FM--EGAQVLLG AHMSRKLRPLLPKEIRLAGDEIP-NDDIHLILEYKAGDKWG-PYVAPRANRYILHNDRNN PHLRAVEQLTDALKMYQPQLLVVSGLQMMDMFTFKSGEREARLQQVQRQLTSQPQGTLNH FEMASYVELQLLQQLR-HFVLPYVDSLGMNEQELSNLQQVLAHGRTTLA--TDWNPRIAH TLDQMRQVFISLLEDYEDRS--------SSDAKRRSISRIHVHTLAYQAILTTAGSKWKN TRAAAAKAALTAHRYVC--KSQFINPEAVLQVLDDSFATS------AQADAPR---MRIG AASPVPCWREYIQYGRHRQRLEVEICVAPVLVCREARKTAGAGDNISASGLAAQL----- ----- >KAG9435874.1 ADP-dependent glucokinase [Apis mellifera carnica] MV---------------------------------------------------------- ---------------------------------------------YVL------------ -----MYINAKDLLN--YSEKIG---------QPQHFDEINTELELLKSFAYYFRHGAAA ERYMANRTLFDELVTKARSFP------SSY--TTIGGNAAIMALRF--AR--EGCDVTLA AKLTRSLHQMIPQVINIVGGEVK-RDDIHLVIEYKHGDIWG-PYSSARANRYIIHNDANN PRISSLDAFDNLLLMYEPNLLVISGLQMMDNYPFPEGDRQKLLHKIKKQMMNRSVSTKIH FEMASFAEDKFLFELC-DSIIPYADSLGMNEQEIANLHNAMYYGNISLV--ANSTPRIAT VLDQMRTLFKLI----RMRS--------KTIENSRELTRIHVHTLAYQAIFTVKSSIWKN TMAAAAKASLTAHRHVC--ATSYVDIKKAALILDDSFSTS-------IVDGTR---IALD IDKPVSCWDEILKIG--NKDIPIQVCVAPVLVCTEAAQTAGGGDNISSAGLVLQI----- ----- >XP_031571788.1 ADP-dependent glucokinase-like [Actinia tenebrosa] MA---------SSYGVVAVLVLIAALFAGYYY---------------------------- --RKISHEKHLRSIMDGMLALE---RNHSV---THS-------PVAVL----------AF ESTMDVFADSFELLK-----ALGIEPP----QKAFPHEVIDSETALAETFAYFFEHSVAS SKYVANKELFRKMAEKANNLQ------STK--FIIGGTAIAFAKRL--TV--ERWRTHLA VLMTESTKKHLPDDITVAGSVPE-DDDIHLILEFPGFENWGDKFVSQRSNRMVLHSDINN PYLKSLEDLKAVTKREEPNIVIIGGLHMLDNFPFKDGERGERLGELAKYLSALSPQVLVH FEMGVFHEHALFVDLL-EYVFPYSDSLGMNEQDLPNLLTMLKDNKITKT--ATQKPRVAA ILDQMRQVYKLL-----RAK--------PLGNGKRKVTRLHLHTLAFQVMMTTKDSSWKN TQAATAKASLTATRYIC--GSNFIHTNKTRLIMDESFSLS------TYPGSDR---MPLN ADNPVPCWDE----------EDYEFCVTPVLVCTDIVHTAGGGDNVSGAGLTLQV----- ----- >NP_001352154.1 ADP-dependent glucokinase isoform 4 precursor [Homo sapiens] MA----------LWRGSAYAGFLA-LAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPP- --GPVSPEGRLAAAWDALIV-------RPV---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSILHSRNDLEEAFIHFMGKGAAA ERFFSDKETFHDIAQVASEFP------GAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWG-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPTGIPVH LELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLS-SWNGVPDVGM VSDILFWILKEH----GRSK-----------SRASDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTSRVSLRAPQEFMTS------HSEAGSR---IVLN PNKPVVEWHR----------EGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEVHPHY ----- >NP_001094193.1 ADP-dependent glucokinase precursor [Rattus norvegicus] MA----------LWRGSACAGFLA-LAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPP- --GSLSPESRLAAAWDALIV-------QPA---RRW-------RRVAV----------GV NACVDVVISGVKLLQ-----ALGLSPG-----SGRDHAVLHSRSDLEEAFVHFMGKGAAA ERFFSDRETFHDIAQAASEFP------GAQ--HYVGGNAALIGQKF--AA-NPDLKVLLC GPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEWG-PFKAPQANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPTGIPVH LELASMTNRELMSSIVHQQVFPAVASLGLNEQELLFLSQSASGPHASLS-SWDGVPDVGM VSDILFWILKEH----GRSK-----------SRSSDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTNRVSLRAPQEFMTS------RLEPGSR---IVLN PNKPVVEWHR----------EGVTFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEAYPD- ----- >XP_004943715.1 ADP-dependent glucokinase isoform X1 [Gallus gallus] ------------MWQRSVCVGLLA-LALGYLCLLGPQLPPSVLQHLSASLLGGLS----- --RAGSLESRMVAAWQAAIV-------RPA---RGW-------GRVAV----------GV NACVDVVLSGVKLLE-----ALGLKPG-----SGKNHDVLNSRQDLREAFTHFMEKGAAA ERFFSDAESFHHIAQTASEHP------GAQ--LYVGGNAALIGQKL--AA-NPDLKILLC GPVGPKLHELLDDSVVVPPESMQERDEFHLILEYQAGEEWG-QVKAPNANRFIFSHDLSN GALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEM--RHRRLMEAVASISDIPTDIPIH LELASMTDQDFMSNIVHQQVFPLVNSIGLNEQELLFLTQSASGPHASLA-SWNGVPDVGA VSDILFWILKEH----GKIA-----------DRASDLTRIHFHTLAYHILATVD-GHWGN QVAAVAAGARAAGVQAC--ATETIDTSKVFLKAPLEFVTS------QIDAPSK---ISLN PDEPVVHWHR----------EGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEIYLQ- ----- >XP_005638630.1 ADP-dependent glucokinase isoform X1 [Canis lupus familiaris] MA----------LWRGSAYAGFLA-LAVGCVLLLEPQLPGSALRSLWSSLQL--APAPP- --GPGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLNPG-----NGKDHSILHSRTDLEEAFVHFMGKGAAA ERFFSDKEAFQDIAQMASELP------GAQ--HYVGGNAALIGQKF--AA-NSELKVLLC GPVGPKLHELLDDNVFVPPESLQEMDEFHLILEYQAGEEWG-RLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPTGVPVH LELASMTNRELMRSIVHQQVFPAVTSLGLNEQELLFLSQAASGPHSSLS-SWNGVPDVGM VSDILFWILKEH----GRSK-----------GRASDLTRIHFHTLVYHILATID-GHWAN QLAAVAAGARVAGTQAC--ATEAIDASRVSLRAPPEFMTS------RSEAGAR---IVIN PNEPVAEWHR----------EGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEARPHS ----- >NP_001075907.1 ADP-dependent glucokinase precursor [Bos taurus] MA----------LWRGSAYAGFLA-LAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPP- --GVGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSELHSRNDLEEAFVHFMGKGAAA ERFFSDKETFHDIAQVASEFP------EAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWD-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEF--QRKRLLEVVTSISDIPTGVPVH LELASMTNKELMSTIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GKSE-----------SRASDLSRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAATQAC--ATETIDTRRVSLKAPHEFMTS------RLEAGSR---VVLN PNEPVVEWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHL ----- >NP_001073434.1 ADP-dependent glucokinase precursor [Danio rerio] ------------MWRKAVLVAVLA-LGMGYLYHTDPELPARMLSYVSQSLPPMEAGGGSE P-RPPTLEEAIARAWQTLIT-------APA---RRW-------GRVAV----------GV NACVDVVVSGVGLLQ-----ALALEPG-----SGRDHEVLHSKEDLKEAFIHYMGKGAAA ERFFSDKEVFQRIARAAAEYP------GAQ--LYVGGNAALIGQKL--AS-NPQLVVLLC GPVGPKLHEMLDEQIVVPPESLQETDEYHLILEYKSGEQWG-PSRAPQANRFILSHDVSN GEMSALEMFVASLEEFQPDLVVLSGLHMMEGMGREL--WEERLKEAVVAISDVRNEVPIH LELASMTDRDYMNRILQEQVMPIVNSIGLNEQELLFLTQSGGGPHSDLT-SWDGVPDVGR VTDILLWVLEQH----GRAD----------AQSEADLTRIHFHTLAYHILATVD-GHWGN QAAAVAAGARVASSQAC--GLQTIDISKVLLKAPLNFHSS------FSEPRES---LKVE PSRPVTVWRR----------GNVSFHLTPVLVCKQPLRTVGLGDAISAEGLVFSELTSEV ----- >XP_016782646.1 ADP-dependent glucokinase isoform X1 [Pan troglodytes] MA----------LWRGSAYAGFLA-LAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPP- --GPVSPEGRLAAAWDALIV-------RPV---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSILHSRNDLEEAFIHFMGKGAAA ERFFSDKETFHDIAQVASEFP------GAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWG-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPTGIPVH LELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLS-SWNGVPDVGM VSDILFWILKEH----GRSK-----------SRASDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTSRVSLRAPQEFMTS------HSEAGSR---IVLN PNKPVVEWHR----------EGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEVHPHY ----- >XP_002825682.1 ADP-dependent glucokinase isoform X1 [Pongo abelii] MA----------LWRGSAYAGFLA-LAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPP- --GPVSPEGRLAATWDALIV-------RPV---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSILHSRNDLEEAFIHFMGKGAAA ERFFSDKETFHDIAQVASEFP------GAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPSESLQEVDEFHLILEYQAGEEWG-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPAGIPVH LELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLS-SWNGVPDVGM VSDILFWILKEH----GRSK-----------SRVSDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTSRVSLRAPQEFMTS------HSEAGSR---IVLN PNKPVVEWHR----------EGISFHFTPVLVCRDPIRTVGLGDAISAEGLFYSEVHPHY ----- >XP_017194042.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Oryctolagus cuniculus] MA----------LWRGSAYAGFLA-LAVGCVFLLEPELPGSALRSLWSSLRLGPAPAAL- --GPASPESRLAAAWDALIV-------QPA---RRW-------RRVAV----------GV NACVDVVLSGVRLLQ-----ALGLRPG-----PGRDHAVLHSRNDLEEAFVHFMGRGAAA ERFFSDKEAFQDIAQVASALP------AAQ--HYVGGNAALIGQKF--AA-NTDLKVLLC GPVGPKLHDLLDDNVFVPPESLQEVDEFHLILEYQAGEEWG-QLKAPHANRFIFSHDLSN GAMNALEVFVSSLEEFQPDLVVLSGLHMMEGQSTEL--QRRRLLEVVTSISDIPTGVPVH LELASMTNRELMSSIVHQQVLPAVASLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GRSE-----------SRASDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAATQAC--ATETIDASRVSLRAPQEFVTS------RLEVGSR---IVLN PREPVVAWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPRS ----- >XP_010715462.1 ADP-dependent glucokinase isoform X1 [Meleagris gallopavo] ------------MWQRSACVGLLA-LALGYLWLLGPQPSPSILQHLSASLLGGLS----- --RAGSLESRMVAAWQAAIV-------RPA---RGW-------GRVAV----------GV NACVDVVLSGVKLLE-----ALGLKPG-----LGKNHDVLNSRQDLREAFTHFMEKGAAA ERFFSDAESFHHIAQTASEHP------GAQ--LYVGGNAALIGQKL--AA-NPDLKILLC GPVGPKLHELLDDNVVVPPESMQERDEFHLILEYQAGEEWG-QVKAPNANRFIFSHDLSN GALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEM--RHRRLMEAVASISDIPTDIPIH LELASMTDQDFMSNIVHQQVFPLVNSIGLNEQELLFLTQSASGPHASLA-SWNGVPDVGA VSDILFWILKEH----GKTA-----------DRASDLTRIHFHTLAYHILATVD-GHWGN QVAAVAAGARAAGAQAC--ATETIDTSRVFLKAPLEFVTS------QIEAPSK---ISLN PDEPVVHWHR----------EGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEINLQ- ----- >XP_020954758.1 ADP-dependent glucokinase isoform X1 [Sus scrofa] MA----------LWRGSVYAGFFA-LAVGCVFLLEPQLPGSALRSLWNSLQLGPVPSPL- --GPGSPEGRLAAAWDALIV-------RPA---RSW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLNPG-----TGKDHTELHSRNDLEEAFIHFMGKGAAA ERFFSDKESFHDIAQIASEFP------GAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEMDEFHLILEYQAGEEWG-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEF--QRKRLLEVVASISDIPTGIPVH LELASMTNRELMGSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-AWTGVPDVGM VSDILFWILKEH----GRSE-----------SRASDLTRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATATIDTHRVSLRAPLEFVTS------RSEAGSR---IVLN PNEPVVEWHR----------EGVSFHFSPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHH ----- >XP_003818615.1 ADP-dependent glucokinase isoform X1 [Pan paniscus] MA----------LWRGSAYAGFLA-LAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPP- --GPVSPEGRLAAAWDALIV-------RPV---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSILHSRNDLEEAFIHFMGKGAAA ERFFSDKETFHDIAQVASEFP------GAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWG-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPTGIPVH LELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLS-SWNGVPDVGM VSDILFWILKEH----GRSK-----------SRASDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTSRVSLRAPQEFMTS------HSEAGSR---IVLN PNKPVVEWHR----------EGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEVHPHY ----- >XP_023110850.1 ADP-dependent glucokinase [Felis catus] MA----------LWRGSAYAGFLA-LAVGCVLLLEPQLPGSALRSLWSSLQL--APAPP- --GPGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLE-----ALGLSPG-----NGKDHTILHSRNDLEEAFIHFMGKGVAA ERFFSDEEAFHDIAQIASELPRSPGLFGSP--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWG-RLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPTGIPVH LELASMTNRELMRSIVH-QVFPAVTSLGLNEQELLFLSQAASGPHSSLS-SWNGVPDVGM VSDILFWILKEH----GRSK-----------SRASDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDASRVSLRAPREFMTS------HSEAGSR---IVID PSRPVAEWHR----------EGVSFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEARPHY ----- >XP_027827363.1 ADP-dependent glucokinase isoform X1 [Ovis aries] MA----------LWRGSAYAGFLA-LAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPP- --GAGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSELHSRNDLEEAFVHFMGKGAAA ERFFSDKETFHDIAQVASEFP------EAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWD-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEF--QRKRLLEVVTSISDIPTGVPVH LELASMTNKELMSSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GKSE-----------SRASDLSRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTRRVSLKAPHEFTTS------RLEAGSR---VVLN PNEPVVEWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHS ----- >XP_018866672.2 ADP-dependent glucokinase isoform X1 [Gorilla gorilla gorilla] MA----------LWRGSAYAGFLA-LAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPP- --GPVSPEGRLAAAWDALIV-------RPV---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSILHSRNDLEEAFIHFMGKGAAA ERFFSDKETFQDIAQVASEFP------GAQ--HYVGGNAALIGQKF--AA-YSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWG-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEL--QRKRLLEVVTSISDIPTGIPVH LELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLS-SWNGVPDVGM VSDILFWILKEH----GRSK-----------SRASDLTRIHFHTLVYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTSRVSLRAPQEFMTS------HSEAGSR---IVLN PNKPVVEWHR----------EGISFHFTPVLVCKDPIRTVGLGDAISAEGLVYSEVHPHY ----- >XP_004069514.1 ADP-dependent glucokinase isoform X1 [Oryzias latipes] ------------MWRKASAAVLLA-LAVGYFYSGSPELPERVLQYF--------NQAS-- --PGNGLEHAISAAWEALIT-------LPS---RQW-------SKVAV----------GV NACVDVVVSGVGLLQ-----ALAVDPG-----AGRDHEVLHSKEDLKEAFIHFMERGAAA ERFFSDEEVFQQIARAAAEYP------GAK--LYVGGNAALMGQKF--AT-YPDLMVLLC GPIGPKLHELLDEQIHVPPESLQEIDEFHLILEYKAGERWG-STQAPQANRFIFSHDVSN GGMSSLETFVASLEEFQPELVVLSGLHMMEGRGREL--WDGRLKQAVMALADIPKDIPIH LELASMTDKDFMNSIMQEQVMPIVSSIGLNEQELLFLSQAGGGPHAALP-AWTGVPEVGR VSDILLWILERH----GRVE----------PSSESELTRIHFHTLAYHILAMVD-GYWGN QAAAVMAGARVASSQAC--GLQAVDPSKVELKAPLEFYSS------HSEPREK---LSLD PTEPVAVWRR----------GNVTFHFTPVLVCKHPLRTVGLGDAISAEGLVYSELKIQQ ---AF >XP_021156443.1 ADP-dependent glucokinase isoform X1 [Columba livia] ------------MHQNNSLLCNKS-TSKGERFSREFQQVNVMLGFFFCILL--------- ----------VVFSLSTRAA-------KSK---RRWLGRDRLVEKVRVVFPVCVLPCSSV NACVDVVLSGVKLLE-----ALGLEPG-----DGKNHAVLTSGQDLREAFAHFMEKGAAA ERFFSDADAFHRIARAAAEHP------GAQ--LYVRGNAALIGQKL--AT-NPELKILLC GPVGPKLHELLDDNVVVPPESMQERDEFHLILEYQAGEEWG-RVRAPNANRFIFSHDLSN GALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEA--RQRRLMEAVASISDIPTDIPIH LELASMTDQDFMSNIVHQQVFPLVNSLGLNEQELLFLTQAAAGPHASLA-AWSGVPDVGV VSDILFWILKEH----GKTA-----------ERASDLTRIHFHTLAYHILVTVD-GYWGN QAAAVAAGARAAGTQAC--ATDTIDTSKVFLKAPLEFVTS------QLEAPAK---ISLN PDEPVVRWHR----------EGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEVYPQ- ----- >XP_017910167.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Capra hircus] MA----------LWRGSAYAGFLA-LAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPP- --GAGSPEGRLAAAWDALIV-------RPA---RRW-------RRVAV----------GV NACVDVVLSGVKLLQ-----ALGLSPG-----NGKDHSELHSRNDLEEAFVHFMGKGAAA ERFFSDKETFHDIAQVASEFP------EAQ--HYVGGNAALIGQKF--AA-NSDLKVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWD-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEF--QRKRLLEVVTSISDIPTGVPVH LELASMTNKELMSSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GKSE-----------SRASDLSRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDTRRVSLKAPHEFTTS------RLEAGSR---VVLN PNEPVVEWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHS ----- >XP_025050700.1 ADP-dependent glucokinase [Alligator sinensis] ------------MRKKGP-------LEQGC------------------------------ ---------------------------------KE-----------------------RV NACVDVVLSGVKLLQ-----ALGLDPG-----NGEDHAVLNSKKDLKEAFSHFMQKGAAA ERFFSDAVSFHHIAQAASEYP------GAQ--LYVGGNAALIGQKL--AT-NPHLKVLLC GPVGPKLHELLDDNVIVPPESMQETDEFHLILEYQAGEEWG-QTRAPNANRFIFSHDLSN GAMNMLEVFVASLDEFQPDLVVLSGLHMMEGQSKEM--RAKRLLAAVTSLSDIPTDIPIH LELASMTDQDLMSKIMLQQVFPLVNSIGLNEQELLFLTQSAAGPHASLT-SWNGVPDVGI VSDILFWILKEH----GRTT-----------DKLSDLTRIHFHTLAYHVLATVD-GYWGN QIAAVAAGARVAGTQAC--ATETIDTDKVSLKAPLEFVTS------QTETNTK---ISLN PGEPVAHWQR----------EGISFHFTPVLVCKDPIRTVGLGDAISAEGLLYSEIYPQ- ----- >XP_015830283.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Nothobranchius furzeri] ------------MWRTASAAVLLA-LAVGYFYHGRPDLPEQILQYVG--LPHLQTSSQ-- --SQKSLEHVVSAAWEALIT-------LPA---HQW-------SKVAV----------GV NACVDVVVSGVGLLQ-----ALAVDPG-----TGLDHEVLHSKEDLKETFIHFMERGAAA ERFFSDSEVFQRIARAAAEYP------GAK--LYVGGNAALIGQKF--AS-YPDLMVLLC GPVGPKLHELLDEQIVVPPGSLQETDEFHLILEYKAGERWG-STQAPQANRFIFSHDVSN GGMSSLEMFVASLEEFQPELVVLSGLHMMEGQGREL--WKERLKQAVASIAEIPKDIPVH LELASMTDKDFMISIVQEQVMPMVSSMGLNEQELLFLSQAAGGPHSALP-AWKGIPDVGR VSDILLWILEHH----GRGA----------ISSESDLTRIHFHTLAYHILATVG-GHWGN QAAAVMAGARVASSQAC--GLRVVDVEKVELKAPLEFYSS------HSEPRDH---LSLN PAEPVMVWHR----------GNVTFHMSPVLVCKHPLRTVGLGDAISAEGLYYSQFKGEQ ---HL >XP_020749492.1 ADP-dependent glucokinase isoform X1 [Odocoileus virginianus texanus] MC----------L----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TEQ--FHGKGADLLIDSML-L------LQVLLC GPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWD-QLKAPHANRFIFSHDLSN GAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGHSKEF--QRKRLLEVVTSISDIPAGVPVH LELASMTNKELMSSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLS-SWNGVPDVGV VSDILFWILKEH----GKSE-----------SRASDLSRIHFHTLAYHILATVD-GHWAN QLAAVAAGARVAGTQAC--ATETIDMRRVSLKAPHEFMTS------RLEAGSR---VVLN PSEPVVEWHR----------EGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEVHPHS ----- >XP_030282616.1 ADP-dependent glucokinase isoform X1 [Sparus aurata] ------------MWRKASVAALLA-LAVGYLYYGGPELSEQILQYIS--LPNIQSPSQNS PNSQKSVEQLISAAWETLIT-------LPT---RQW-------SKVAV----------GV NACVDVVVSGVGLLQ-----ALAVDPG-----VGLDHEVLHSKEDLREAFIHYMERGAAA ERFFSNKEVFQRIARAAAEYP------GAK--LYVGGNAALIGQKL--AT-YPDLMVLLC GPVGPKLHEMLDEQIVVPPESLQETDEYHLILEYKAGEQWG-SVQAPQANRFIFSHDVSN GAMSSLETFVASLDDFQPELVVLSGLHMMEGQGRQL--WEERLKEAVSAISDIRRDVPIH LELASMTDKDYMNSIMQEQVMPIVSSIGLNEQELLFLSQAGEGPHSDMA-TWKGIPDMGR VSDILLWILEQH----GRSD----------PSSEADLTRIHFHTLAYHILATVD-GYWGN QAAAVMAGARVASSQSC--GLQSVDVSKVELKAPLDFHSS------HAEPREK---LSLN PAEPVTVWQR----------GNVTFHMTPVLVCKQPLRTVGLGDAISAEGLIYSELKTQQ ---PI >XP_040198962.1 ADP-dependent glucokinase isoform X1 [Rana temporaria] ------------MWVK-VCVGLMA-MAVGLLHHLQPNLLEAAQDYFSSSLQSI-SPGVT- P-SHPSLEEALSTTWDTLIT-------APA---KHW-------GKVAV----------GV NACVDVVVSGVSLLK-----ALGLSPQ-----PGGDHLVLNAQEELAETFQHYMQRGAAA ERFYSDADSFQHISRTASQEP------GAK--HFVGGNAALIAQRL--AT-HPDLEVLLC GPIGPKLHELLDERIVVPPASLKDQDEYHLILEYKAGEKWG-SGQAPAASRFIFSHDLSN GAMTSLEVLLSSLEEFQPKLLVLSGLHMMEGLSQEA--RANRLQEAATALSDVPSDILIH LELASMTDGDLMRGIIHQQVFPVISSVGLNEQELLFLSQSSSGPHSALP-AWSGIPDVGI VSDILFWILKGS----V--------------RGDSALTRVHFHTLAYHILATVD-DFWGN QVAAVAAGARIAGAQAC--ASEIIEPSKVMLKSPLEFSTS------KTDMGPT---ARVS AKEPVAVWRK----------DGVTFHFTPVLICKEPVRTVGLGDAISAEGLLFSEAKTQ- -----
BMGE Cleaned alignment of selected proteins >NP_082397.1 ADP-dependent glucokinase isoform 1 precursor [Mus musculus] LWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPVGPLSPESRLAAAWDALIARRVAVGVNACVDVVISGVKLLQALGLSPGSGKDHAILHSRSDLEEAFLYFMGKGAAAERFFSDKETFHDIAQAASEFPHYVGGNAALIGQRFNTDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEWGFKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTAISDIPTGIPVHLELASMTNRELMSIVHQQVFPTVASLGLNEQELLFLSQSASGPHASLSSWDGVPDVGMVSDILFWILKEHRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTNRVSLRAPQEFTTSLESGSRIVLNPDKPVVEWHREGITFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEA >KAB0375010.1 hypothetical protein FD755_013502 [Muntiacus reevesi] LWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLRALGLSPGNGKDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSLSDIPTGVPVHLELASMTNKELMNIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTRRVSLKAPHEFMTSLEAGSRVVLNPSEPVVAWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >KAB0342610.1 hypothetical protein FD754_019536 [Muntiacus muntjak] LWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLRALGLSPGNGKDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDLKAPHANRFIFSHDLSNGAMSMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSLSDIPTGVPVHLELASMTNKELMNIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTRRVSLKAPHEFMTSLEAGSRVVLNPSEPVVAWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >XP_043326947.1 ADP-dependent glucokinase isoform X1 [Cervus canadensis] LWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLRALGLSPGNGRDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSLSDIPMGVPVHLELASMTNKELMNIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTRRVSLKAPHEFMTSLEAGSKVVLNPSEPVVAWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >XP_018108378.1 ADP-dependent glucokinase isoform X1 [Xenopus laevis] MWPKAVCVGLLAISLGLLHHLHPEISDAALDYLSSSLQSIASREPASSPPIEEAFSAAWDRLIVERVAVGVNACVDVVLSGIGLLQALALTPQSSEDHMVLNTQEDLAETFLHYMQQGAAAERFYSDAKSFAHISRTASQDPHFVGGNAALIAQRLNPDMEVLLCGPVGPKLHELLDERVFVPPTSLQEEDEYHLILEYKSGEQWGRQAPAASRFIFSHDLSNGAMTSLEVLLSSLEVFQPKLLVLSGLHMMEGLSREAREERLREAAASLSEVPSDILIHLELASMTDGDLMGIIYQQVFPFISSLGLNEQELLFLSHSASGPHASISAWSGIPEVGIVSDILFWILKGSEASSLTRIHFHTLAYHILATIDGFWGNQVSAVAAGARVAGTQACASETIDATRVKLKTPLEFSTSEQVGSTVRVSAQEPVAVWIREGVTFHFTPVLICKEPVRTVGLGDAISAEGLLFSEA >XP_038076901.1 ADP-dependent glucokinase-like [Patiria miniata] MEWGPLILAFALIAAAYLYGFNLKSTNT-------------EPNVRQVTSAESQVLQGWDQQIQKRVAVGLNVNADLIVSATSLLDKLGIQPAVSQDHTLLNSLKDLQESFAFFFESGAAAERYFANGEVYKRIIEEADKLEYSVGGNAALMAYKMTDDVQILLIGPIGPKVHSLMPSSVNIHETSLRDTDEVHLIMEYAKGEKWGLTTPIATRFITSHDVANAELDGLNVFSSSVKEFNPDVVMFSGLHLLDSSSQSEQQNKLSALVTELKKLPKSLPLHLELASMANEGLVFIV-AQVLSSVHSLGLNEQELGLVSRANNGPHPDITEESGYIEIGAVADILYWILTSL-SSLLTRVHFHSLTFHVVATLPNQWDNSVSAVGVGARIAGRQACGDVPIQPSKVTLRIPKAFPLSDYAPLRVIVDPSNPLMTWKRGQVTFHFSPVLVCKKPGKTVGLGDAISATAMLYTQY >XP_793568.3 ADP-dependent glucokinase [Strongylocentrotus purpuratus] MFSNTFVIGVVLIAVSLYYSVHFNHDR-------------------SAISVESQIAIAWGNVIASRIAVGVNVNTDLIVSGTAVLKKLGIDSSQAIDNAVIESLEELEQTFAFSLKNGAAIERIFSRSEDFEKVVQAADSLDYFVGGNAALAGLKMWKGLEVLLIGPCGPRVRALLPPNIIVPKPSYKETDEVHLIMEFKRNERWGYEAKVATRFISSYDVSNTEMSALSEFSRSVTDFSPDAVFFSGLHLLDGQPGVKKEEKMAALNQELSRLPSDLPVHLELASMADPELIGIY-TQVLSSVHSLGLNEQELSFMSSVNSGPHPEVYIRDGYPEVGAVADILYWILTSTWSSTLTRVHFHSLAFHIVATMNGTWINNAAAVSAGARIAGRQACDDGRIVDEKVELRVPQAFALSNHAPLRVSVDPQNPVISWTRDNIQFHFTPVLVCKNPVKTVGLGDAISSTGFLFSQM >XP_039273116.1 ADP-dependent glucokinase-like [Styela clava] TWRKALFI--CCMAGGILWFSNP-ISDYFFDYLA------------DPNEMEIIIAKSWNKTIDHAIAIGINAGIDIIVKGTDLLKKLGTDEKKATDRESINNLRQLQEVFTYFHSKGAGGERFMNNKELFAKAVGMSKAMPLYVGGNAALMAQAIAKNVHVLFGGMVGPGLSPMLNRRLIVPSKLKAEEDEYHIILEYVKGEKWAHVCPIASRFIFSHDLTNSRMLASEKFIDSLKEFNPDMVVLTGLHLLEGQPEAYWKRRLAEIAASLAKVSTNVPIHTELASMANPAFVALT-ERILPMVDSIGLNEQELWMTCQANGGPHCKPEELDGPPSPGVSNDIIHWMLQQFPSSRLSRVHFHTLVYHTVATLDSKWRYGDSSVAAGARIASTQSCGVHSVHPAKVELRLKSTIPLTVEQPKDTRLDYSNPIISWKTSKISFFMTPVLVCQNPVKTVGLGDAISSMGLLHSGY >NP_493657.2 putative ADP-dependent glucokinase [Caenorhabditis elegans] YKHRLLHLSVLFFIVPYWYSYYNDQHRL------------------SSYSVETAMFLSWERAIVKKAVIGFNCNVDLIVSGVRVVDALNTTCSEGKDQETLETLADLHQTFAHFFQRGAAAERYMSSEDQFNLLVAESEASTHHIGGNAALMADRIFPSTEVYLVGPIGPRSQALLHPSVKRTNSTRILKDELHVILEYKQGEILGWVAPSSSRFITSHDHFSGSMVVMEMFFKAIAQFRPDLVVITGVHLLEFQSKEMRQEKMRLIKRNLLQIPPKVPIHLELGSLADEIFSDVI-NKILPYVDSLGINEQELTFLSHIANGPHMEEYVQAGTVHVHKVVEMLHWLLKTYTGYRLSRIHFHCLTYHIMVSSGTDWSNLAAGLAAGARIAGRLSCGANTMDSELLEIRTPANFVLDKKIEKNYQFEAHNPIASWMREDVLFVFTPVLVCRLPSKTVGIDDAISATGLLYSQF >OWK09674.1 ADPGK [Cervus elaphus hippelaphus] LWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLRALGLSPGNGRDHSELRSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQIASEFPSF----------------------------------------------------------------------------------------------------CFSG-------------------------------------------------RSISPVETGSG------------------RLS-----------TSLLVFALRKH---------------------------------------------------------------------------------------IFVHMSHI-------------------------- >CAE1165978.1 ADPGK [Sepia pharaonis] ----------------------------------------------------------------ENNVPEVEYYLRSFLLFTKLFEKLDYSPPKVRHHSSLQTPEQLQELFAYFFQFGAAAERYVNNDTFFEELWKNANSIKWFLGGNALSMAQRL-EGAEVLLGMSHSKKLRALLPPEVKVAGPNLV-TDDIHLILEYNKGDNWGFTSPRANRLILHSDNSNPQLEALENFQEQLDSFQPSLLVLGGLQMMDNFPYEPRTGRLNKVQEMLSSLPRKTKVHFEFASFTDMDLLEIM-AKVIIYADSIGLNEQELPNLVTLLNDGSVTVV-SDSYPRIATVLDQMRFVYSHLGRRRLTRLHVHTIAFQAILTDKSTWKNSMSATAKAALTAHRHVCGSADIDTLKARILMDDSFSTSLKSAQRIPLQKNRPVSCWDEDRFQICIAPVLVCTKVQQTAGGGDNISSAGLVLQV- >NP_001246747.1 uncharacterized protein Dmel_CG6650, isoform B [Drosophila melanogaster] ITGCSVLTAFVSIWQAF-----------------------------IALQTLNRTTVLLTGLLAPKVAIGYGACTDLQINATEFLDRIPVAAATTGSRAVVNNEDELLQSFAYYFQNGAAAERVMANSTLFTQLVGYAKVMDWYMGGNAPLMAVRF-EGAQVLLGAHMSRKLRPLLPKEIRLAGDEIP-NDDIHLILEYKAGDKWGYVAPRANRYILHNDRNNPHLRAVEQLTDALKMYQPQLLVVSGLQMMDMFTFKSREARLQQVQRQLTSQPQGTLNHFEMASYVELQLLQLR-HFVLPYVDSLGMNEQELSNLQQVLAHGRTTLA-TDWNPRIAHTLDQMRQVFISLKRRSISRIHVHTLAYQAILTTASKWKNTRAAAAKAALTAHRYVCKSQFINPEAVLQVLDDSFATSQADAPRMRIGAASPVPCWRELEVEICVAPVLVCREARKTAGAGDNISASGLAAQL- >KAG9435874.1 ADP-dependent glucokinase [Apis mellifera carnica] ------------------------------------------------------------------YVL-------MYINAKDLLNKIG----QPQHFDEINTELELLKSFAYYFRHGAAAERYMANRTLFDELVTKARSFPTTIGGNAAIMALRF-EGCDVTLAAKLTRSLHQMIPQVINIVGGEVK-RDDIHLVIEYKHGDIWGYSSARANRYIIHNDANNPRISSLDAFDNLLLMYEPNLLVISGLQMMDNYPFPERQKLLHKIKKQMMNRSVSTKIHFEMASFAEDKFLELC-DSIIPYADSLGMNEQEIANLHNAMYYGNISLV-ANSTPRIATVLDQMRTLFKLINSRELTRIHVHTLAYQAIFTVKSIWKNTMAAAAKASLTAHRHVCATSYVDIKKAALILDDSFSTSIVDGTRIALDIDKPVSCWDEIPIQVCVAPVLVCTEAAQTAGGGDNISSAGLVLQI- >XP_031571788.1 ADP-dependent glucokinase-like [Actinia tenebrosa] SYGVVAVLVLIALFAGYYY---------------------------RKISHEKHLRSIMDGMLAPVAVLAFESTMDVFADSFELLKALGIEPPKAFPHEVIDSETALAETFAYFFEHSVASSKYVANKELFRKMAEKANNLQFIIGGTAIAFAKRL-ERWRTHLAVLMTESTKKHLPDDITVAGSVPE-DDDIHLILEFPGFENWGFVSQRSNRMVLHSDINNPYLKSLEDLKAVTKREEPNIVIIGGLHMLDNFPFKDRGERLGELAKYLSALSPQVLVHFEMGVFHEHALFDLL-EYVFPYSDSLGMNEQDLPNLLTMLKDNKITKT-ATQKPRVAAILDQMRQVYKLLGKRKVTRLHLHTLAFQVMMTTKSSWKNTQAATAKASLTATRYICGSNFIHTNKTRLIMDESFSLSYPGSDRMPLNADNPVPCWDEEDYEFCVTPVLVCTDIVHTAGGGDNVSGAGLTLQV- >NP_001352154.1 ADP-dependent glucokinase isoform 4 precursor [Homo sapiens] LWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFHDIAQVASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILFWILKEHRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEV >NP_001094193.1 ADP-dependent glucokinase precursor [Rattus norvegicus] LWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPAPVPPGSLSPESRLAAAWDALIVRRVAVGVNACVDVVISGVKLLQALGLSPGSGRDHAVLHSRSDLEEAFVHFMGKGAAAERFFSDRETFHDIAQAASEFPHYVGGNAALIGQKFNPDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEWGFKAPQANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSIVHQQVFPAVASLGLNEQELLFLSQSASGPHASLSSWDGVPDVGMVSDILFWILKEHRSSDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTNRVSLRAPQEFMTSLEPGSRIVLNPNKPVVEWHREGVTFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEA >XP_004943715.1 ADP-dependent glucokinase isoform X1 [Gallus gallus] MWQRSVCVGLLALALGYLCLLGPQLPPSVLQHLSASLLGGLS----RAGSLESRMVAAWQAAIVGRVAVGVNACVDVVLSGVKLLEALGLKPGSGKNHDVLNSRQDLREAFTHFMEKGAAAERFFSDAESFHHIAQTASEHPLYVGGNAALIGQKLNPDLKILLCGPVGPKLHELLDDSVVVPPESMQERDEFHLILEYQAGEEWGVKAPNANRFIFSHDLSNGALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEMRHRRLMEAVASISDIPTDIPIHLELASMTDQDFMNIVHQQVFPLVNSIGLNEQELLFLTQSASGPHASLASWNGVPDVGAVSDILFWILKEHRASDLTRIHFHTLAYHILATVDGHWGNQVAAVAAGARAAGVQACATETIDTSKVFLKAPLEFVTSIDAPSKISLNPDEPVVHWHREGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEI >XP_005638630.1 ADP-dependent glucokinase isoform X1 [Canis lupus familiaris] LWRGSAYAGFLALAVGCVLLLEPQLPGSALRSLWSSLQL--APAPPGPGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLNPGNGKDHSILHSRTDLEEAFVHFMGKGAAAERFFSDKEAFQDIAQMASELPHYVGGNAALIGQKFNSELKVLLCGPVGPKLHELLDDNVFVPPESLQEMDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGVPVHLELASMTNRELMSIVHQQVFPAVTSLGLNEQELLFLSQAASGPHSSLSSWNGVPDVGMVSDILFWILKEHRASDLTRIHFHTLVYHILATIDGHWANQLAAVAAGARVAGTQACATEAIDASRVSLRAPPEFMTSSEAGARIVINPNEPVAEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEA >NP_001075907.1 ADP-dependent glucokinase precursor [Bos taurus] LWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGVGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSELHSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQVASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSISDIPTGVPVHLELASMTNKELMTIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAATQACATETIDTRRVSLKAPHEFMTSLEAGSRVVLNPNEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >NP_001073434.1 ADP-dependent glucokinase precursor [Danio rerio] MWRKAVLVAVLALGMGYLYHTDPELPARMLSYVSQSLPPMEAGGGSRPPTLEEAIARAWQTLITGRVAVGVNACVDVVVSGVGLLQALALEPGSGRDHEVLHSKEDLKEAFIHYMGKGAAAERFFSDKEVFQRIARAAAEYPLYVGGNAALIGQKLNPQLVVLLCGPVGPKLHEMLDEQIVVPPESLQETDEYHLILEYKSGEQWGSRAPQANRFILSHDVSNGEMSALEMFVASLEEFQPDLVVLSGLHMMEGMGRELWEERLKEAVVAISDVRNEVPIHLELASMTDRDYMRILQEQVMPIVNSIGLNEQELLFLTQSGGGPHSDLTSWDGVPDVGRVTDILLWVLEQHSEADLTRIHFHTLAYHILATVDGHWGNQAAAVAAGARVASSQACGLQTIDISKVLLKAPLNFHSSSEPRESLKVEPSRPVTVWRRGNVSFHLTPVLVCKQPLRTVGLGDAISAEGLVFSEL >XP_016782646.1 ADP-dependent glucokinase isoform X1 [Pan troglodytes] LWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFHDIAQVASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILFWILKEHRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEV >XP_002825682.1 ADP-dependent glucokinase isoform X1 [Pongo abelii] LWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAATWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFHDIAQVASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPSESLQEVDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPAGIPVHLELASMTNRELMSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILFWILKEHRVSDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCRDPIRTVGLGDAISAEGLFYSEV >XP_017194042.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Oryctolagus cuniculus] LWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLRLGPAPAALGPASPESRLAAAWDALIVRRVAVGVNACVDVVLSGVRLLQALGLRPGPGRDHAVLHSRNDLEEAFVHFMGRGAAAERFFSDKEAFQDIAQVASALPHYVGGNAALIGQKFNTDLKVLLCGPVGPKLHDLLDDNVFVPPESLQEVDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNALEVFVSSLEEFQPDLVVLSGLHMMEGQSTELQRRRLLEVVTSISDIPTGVPVHLELASMTNRELMSIVHQQVLPAVASLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAATQACATETIDASRVSLRAPQEFVTSLEVGSRIVLNPREPVVAWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >XP_010715462.1 ADP-dependent glucokinase isoform X1 [Meleagris gallopavo] MWQRSACVGLLALALGYLWLLGPQPSPSILQHLSASLLGGLS----RAGSLESRMVAAWQAAIVGRVAVGVNACVDVVLSGVKLLEALGLKPGLGKNHDVLNSRQDLREAFTHFMEKGAAAERFFSDAESFHHIAQTASEHPLYVGGNAALIGQKLNPDLKILLCGPVGPKLHELLDDNVVVPPESMQERDEFHLILEYQAGEEWGVKAPNANRFIFSHDLSNGALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEMRHRRLMEAVASISDIPTDIPIHLELASMTDQDFMNIVHQQVFPLVNSIGLNEQELLFLTQSASGPHASLASWNGVPDVGAVSDILFWILKEHRASDLTRIHFHTLAYHILATVDGHWGNQVAAVAAGARAAGAQACATETIDTSRVFLKAPLEFVTSIEAPSKISLNPDEPVVHWHREGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEI >XP_020954758.1 ADP-dependent glucokinase isoform X1 [Sus scrofa] LWRGSVYAGFFALAVGCVFLLEPQLPGSALRSLWNSLQLGPVPSPLGPGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLNPGTGKDHTELHSRNDLEEAFIHFMGKGAAAERFFSDKESFHDIAQIASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEMDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVASISDIPTGIPVHLELASMTNRELMSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSAWTGVPDVGMVSDILFWILKEHRASDLTRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATATIDTHRVSLRAPLEFVTSSEAGSRIVLNPNEPVVEWHREGVSFHFSPVLVCKDPVRTVGLGDAISAEGLFYSEV >XP_003818615.1 ADP-dependent glucokinase isoform X1 [Pan paniscus] LWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFHDIAQVASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILFWILKEHRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEV >XP_023110850.1 ADP-dependent glucokinase [Felis catus] LWRGSAYAGFLALAVGCVLLLEPQLPGSALRSLWSSLQL--APAPPGPGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLEALGLSPGNGKDHTILHSRNDLEEAFIHFMGKGVAAERFFSDEEAFHDIAQIASELPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSIVH-QVFPAVTSLGLNEQELLFLSQAASGPHSSLSSWNGVPDVGMVSDILFWILKEHRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDASRVSLRAPREFMTSSEAGSRIVIDPSRPVAEWHREGVSFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEA >XP_027827363.1 ADP-dependent glucokinase isoform X1 [Ovis aries] LWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSELHSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQVASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSISDIPTGVPVHLELASMTNKELMSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTRRVSLKAPHEFTTSLEAGSRVVLNPNEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >XP_018866672.2 ADP-dependent glucokinase isoform X1 [Gorilla gorilla gorilla] LWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFQDIAQVASEFPHYVGGNAALIGQKFYSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELASMTNRELMSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILFWILKEHRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLVYSEV >XP_004069514.1 ADP-dependent glucokinase isoform X1 [Oryzias latipes] MWRKASAAVLLALAVGYFYSGSPELPERVLQYF--------NQAS-PGNGLEHAISAAWEALITSKVAVGVNACVDVVVSGVGLLQALAVDPGAGRDHEVLHSKEDLKEAFIHFMERGAAAERFFSDEEVFQQIARAAAEYPLYVGGNAALMGQKFYPDLMVLLCGPIGPKLHELLDEQIHVPPESLQEIDEFHLILEYKAGERWGTQAPQANRFIFSHDVSNGGMSSLETFVASLEEFQPELVVLSGLHMMEGRGRELWDGRLKQAVMALADIPKDIPIHLELASMTDKDFMSIMQEQVMPIVSSIGLNEQELLFLSQAGGGPHAALPAWTGVPEVGRVSDILLWILERHSESELTRIHFHTLAYHILAMVDGYWGNQAAAVMAGARVASSQACGLQAVDPSKVELKAPLEFYSSSEPREKLSLDPTEPVAVWRRGNVTFHFTPVLVCKHPLRTVGLGDAISAEGLVYSEL >XP_021156443.1 ADP-dependent glucokinase isoform X1 [Columba livia] MHQNNSLLCNKSTSKGERFSREFQQVNVMLGFFFCILL----------------VVFSLSTRAAEKVRVSVNACVDVVLSGVKLLEALGLEPGDGKNHAVLTSGQDLREAFAHFMEKGAAAERFFSDADAFHRIARAAAEHPLYVRGNAALIGQKLNPELKILLCGPVGPKLHELLDDNVVVPPESMQERDEFHLILEYQAGEEWGVRAPNANRFIFSHDLSNGALNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEARQRRLMEAVASISDIPTDIPIHLELASMTDQDFMNIVHQQVFPLVNSLGLNEQELLFLTQAAAGPHASLAAWSGVPDVGVVSDILFWILKEHRASDLTRIHFHTLAYHILVTVDGYWGNQAAAVAAGARAAGTQACATDTIDTSKVFLKAPLEFVTSLEAPAKISLNPDEPVVRWHREGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSEV >XP_017910167.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Capra hircus] LWRGSAYAGFLALAVGCVFLLEPQLPGSALRSLWSSLQLGPAPAPPGAGSPEGRLAAAWDALIVRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSELHSRNDLEEAFVHFMGKGAAAERFFSDKETFHDIAQVASEFPHYVGGNAALIGQKFNSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKEFQRKRLLEVVTSISDIPTGVPVHLELASMTNKELMSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTRRVSLKAPHEFTTSLEAGSRVVLNPNEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >XP_025050700.1 ADP-dependent glucokinase [Alligator sinensis] MRKKGP------LEQGC----------------------------------------------------RVNACVDVVLSGVKLLQALGLDPGNGEDHAVLNSKKDLKEAFSHFMQKGAAAERFFSDAVSFHHIAQAASEYPLYVGGNAALIGQKLNPHLKVLLCGPVGPKLHELLDDNVIVPPESMQETDEFHLILEYQAGEEWGTRAPNANRFIFSHDLSNGAMNMLEVFVASLDEFQPDLVVLSGLHMMEGQSKEMRAKRLLAAVTSLSDIPTDIPIHLELASMTDQDLMKIMLQQVFPLVNSIGLNEQELLFLTQSAAGPHASLTSWNGVPDVGIVSDILFWILKEHKLSDLTRIHFHTLAYHVLATVDGYWGNQIAAVAAGARVAGTQACATETIDTDKVSLKAPLEFVTSTETNTKISLNPGEPVAHWQREGISFHFTPVLVCKDPIRTVGLGDAISAEGLLYSEI >XP_015830283.1 PREDICTED: ADP-dependent glucokinase isoform X1 [Nothobranchius furzeri] MWRTASAAVLLALAVGYFYHGRPDLPEQILQYVG--LPHLQTSSQ-SQKSLEHVVSAAWEALITSKVAVGVNACVDVVVSGVGLLQALAVDPGTGLDHEVLHSKEDLKETFIHFMERGAAAERFFSDSEVFQRIARAAAEYPLYVGGNAALIGQKFYPDLMVLLCGPVGPKLHELLDEQIVVPPGSLQETDEFHLILEYKAGERWGTQAPQANRFIFSHDVSNGGMSSLEMFVASLEEFQPELVVLSGLHMMEGQGRELWKERLKQAVASIAEIPKDIPVHLELASMTDKDFMSIVQEQVMPMVSSMGLNEQELLFLSQAAGGPHSALPAWKGIPDVGRVSDILLWILEHHSESDLTRIHFHTLAYHILATVGGHWGNQAAAVMAGARVASSQACGLRVVDVEKVELKAPLEFYSSSEPRDHLSLNPAEPVMVWHRGNVTFHMSPVLVCKHPLRTVGLGDAISAEGLYYSQF >XP_020749492.1 ADP-dependent glucokinase isoform X1 [Odocoileus virginianus texanus] L---------------------------------------------------------------------------------------------------------------------------------------------FHGKGADLLIDSML---LQVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWDLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGHSKEFQRKRLLEVVTSISDIPAGVPVHLELASMTNKELMSIVHQQVFPAVTSLGLNEQELLFLSQSASGPHSSLSSWNGVPDVGVVSDILFWILKEHRASDLSRIHFHTLAYHILATVDGHWANQLAAVAAGARVAGTQACATETIDMRRVSLKAPHEFMTSLEAGSRVVLNPSEPVVEWHREGVSFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEV >XP_030282616.1 ADP-dependent glucokinase isoform X1 [Sparus aurata] MWRKASVAALLALAVGYLYYGGPELSEQILQYIS--LPNIQSPSQNSQKSVEQLISAAWETLITSKVAVGVNACVDVVVSGVGLLQALAVDPGVGLDHEVLHSKEDLREAFIHYMERGAAAERFFSNKEVFQRIARAAAEYPLYVGGNAALIGQKLYPDLMVLLCGPVGPKLHEMLDEQIVVPPESLQETDEYHLILEYKAGEQWGVQAPQANRFIFSHDVSNGAMSSLETFVASLDDFQPELVVLSGLHMMEGQGRQLWEERLKEAVSAISDIRRDVPIHLELASMTDKDYMSIMQEQVMPIVSSIGLNEQELLFLSQAGEGPHSDMATWKGIPDMGRVSDILLWILEQHSEADLTRIHFHTLAYHILATVDGYWGNQAAAVMAGARVASSQSCGLQSVDVSKVELKAPLDFHSSAEPREKLSLNPAEPVTVWQRGNVTFHMTPVLVCKQPLRTVGLGDAISAEGLIYSEL >XP_040198962.1 ADP-dependent glucokinase isoform X1 [Rana temporaria] MWVK-VCVGLMAMAVGLLHHLQPNLLEAAQDYFSSSLQSI-SPGVTSHPSLEEALSTTWDTLITGKVAVGVNACVDVVVSGVSLLKALGLSPQPGGDHLVLNAQEELAETFQHYMQRGAAAERFYSDADSFQHISRTASQEPHFVGGNAALIAQRLHPDLEVLLCGPIGPKLHELLDERIVVPPASLKDQDEYHLILEYKAGEKWGGQAPAASRFIFSHDLSNGAMTSLEVLLSSLEEFQPKLLVLSGLHMMEGLSQEARANRLQEAATALSDVPSDILIHLELASMTDGDLMGIIHQQVFPVISSVGLNEQELLFLSQSSSGPHSALPAWSGIPDVGIVSDILFWILKGSGDSALTRVHFHTLAYHILATVDDFWGNQVAAVAAGARIAGAQACASEIIEPSKVMLKSPLEFSTSTDMGPTARVSAKEPVAVWRKDGVTFHFTPVLICKEPVRTVGLGDAISAEGLLFSEA
PhyML tree of selected proteins (XP_040198962_1_ADP_dependent_glucokinase_isoform_X1__Rana_temporaria_:0.14812367,XP_018108378_1_ADP_dependent_glucokinase_isoform_X1__Xenopus_laevis_:0.1254651,((((XP_021156443_1_ADP_dependent_glucokinase_isoform_X1__Columba_livia_:0.19581162,(XP_004943715_1_ADP_dependent_glucokinase_isoform_X1__Gallus_gallus_:0.01005849,XP_010715462_1_ADP_dependent_glucokinase_isoform_X1__Meleagris_gallopavo_:0.01287093):0.02728768):0.07435152,(XP_025050700_1_ADP_dependent_glucokinase__Alligator_sinensis_:0.11251646,((((XP_002825682_1_ADP_dependent_glucokinase_isoform_X1__Pongo_abelii_:0.01086128,(XP_018866672_2_ADP_dependent_glucokinase_isoform_X1__Gorilla_gorilla_gorilla_:0.0065213,(XP_016782646_1_ADP_dependent_glucokinase_isoform_X1__Pan_troglodytes_:0.00000001,(NP_001352154_1_ADP_dependent_glucokinase_isoform_4_precursor__Homo_sapiens_:0.00000001,XP_003818615_1_ADP_dependent_glucokinase_isoform_X1__Pan_paniscus_:0.00000001):0.00000001):0.00000001):0.00000001):0.01048012,(XP_017194042_1_PREDICTED__ADP_dependent_glucokinase_isoform_X1__Oryctolagus_cuniculus_:0.06058619,(NP_082397_1_ADP_dependent_glucokinase_isoform_1_precursor__Mus_musculus_:0.02516305,NP_001094193_1_ADP_dependent_glucokinase_precursor__Rattus_norvegicus_:0.01604741):0.04052489):0.01642858):0.00769724,(XP_005638630_1_ADP_dependent_glucokinase_isoform_X1__Canis_lupus_familiaris_:0.02776696,XP_023110850_1_ADP_dependent_glucokinase__Felis_catus_:0.01929346):0.0216809):0.00400968,(XP_020954758_1_ADP_dependent_glucokinase_isoform_X1__Sus_scrofa_:0.04578455,(NP_001075907_1_ADP_dependent_glucokinase_precursor__Bos_taurus_:0.00653542,((XP_027827363_1_ADP_dependent_glucokinase_isoform_X1__Ovis_aries_:0.00000001,XP_017910167_1_PREDICTED__ADP_dependent_glucokinase_isoform_X1__Capra_hircus_:0.00000001):0.00218422,(XP_020749492_1_ADP_dependent_glucokinase_isoform_X1__Odocoileus_virginianus_texanus_:0.05556455,(KAB0342610_1_hypothetical_protein_FD754_019536__Muntiacus_muntjak_:0.0021772,(KAB0375010_1_hypothetical_protein_FD755_013502__Muntiacus_reevesi_:0.00000001,(XP_043326947_1_ADP_dependent_glucokinase_isoform_X1__Cervus_canadensis_:0.00000001,OWK09674_1_ADPGK__Cervus_elaphus_hippelaphus_:0.15713704):0.00654854):0.00000001):0.01184698):0.00348574):0.00000001):0.02502787):0.00618343):0.18987317):0.00729522):0.13489462,(NP_001073434_1_ADP_dependent_glucokinase_precursor__Danio_rerio_:0.14351271,(XP_030282616_1_ADP_dependent_glucokinase_isoform_X1__Sparus_aurata_:0.06205983,(XP_004069514_1_ADP_dependent_glucokinase_isoform_X1__Oryzias_latipes_:0.09310513,XP_015830283_1_PREDICTED__ADP_dependent_glucokinase_isoform_X1__Nothobranchius_furzeri_:0.08151718):0.06070753):0.0793541):0.22927135):0.05318353,((XP_039273116_1_ADP_dependent_glucokinase_like__Styela_clava_:1.06279224,(NP_493657_2_putative_ADP_dependent_glucokinase__Caenorhabditis_elegans_:1.29211236,(XP_038076901_1_ADP_dependent_glucokinase_like__Patiria_miniata_:0.5829422,XP_793568_3_ADP_dependent_glucokinase__Strongylocentrotus_purpuratus_:0.43154099):0.33445942):0.11249025):0.09222538,((KAG9435874_1_ADP_dependent_glucokinase__Apis_mellifera_carnica_:0.56774241,NP_001246747_1_uncharacterized_protein_Dmel_CG6650__isoform_B__Drosophila_melanogaster_:0.66547467):0.11624483,(XP_031571788_1_ADP_dependent_glucokinase_like__Actinia_tenebrosa_:0.96252514,CAE1165978_1_ADPGK__Sepia_pharaonis_:0.57456519):0.17389311):1.57621403):0.40236863):0.19825908);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)