Click here to access PB0019 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0019 P02452 Collagen type I alpha 1 chain COL1A1 CAFYD, EDSARTH1, EDSC, OI1, OI2, OI3, OI4, Collagen alpha-1(I) chain Homo_sapiens Type I collagen is a member of group I collagen (fibrillar forming collagen).

DomainsGene Ontology
PF00093 (VWC)
PF01391 (11_Collagen)
PF01410 (COLFI)
GO:0002020 (enables) protease binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0042802 (enables) identical protein binding
GO:0046872 (enables) metal ion binding
GO:0048407 (enables) platelet-derived growth factor binding
GO:0001501 (involved in) skeletal system development
GO:0001503 (involved in) ossification
GO:0001568 (involved in) blood vessel development
GO:0001649 (involved in) osteoblast differentiation
GO:0001957 (involved in) intramembranous ossification
GO:0001958 (involved in) endochondral ossification
GO:0007584 (involved in) response to nutrient
GO:0007601 (involved in) visual perception
GO:0007605 (involved in) sensory perception of sound
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009612 (involved in) response to mechanical stimulus
GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition
GO:0010812 (involved in) negative regulation of cell-substrate adhesion
GO:0015031 (involved in) protein transport
GO:0030198 (involved in) extracellular matrix organization
GO:0030199 (involved in) collagen fibril organization
GO:0030335 (involved in) positive regulation of cell migration
GO:0031667 (involved in) response to nutrient levels
GO:0031960 (involved in) response to corticosteroid
GO:0032355 (involved in) response to estradiol
GO:0032964 (involved in) collagen biosynthetic process
GO:0034504 (involved in) protein localization to nucleus
GO:0034505 (involved in) tooth mineralization
GO:0038063 (involved in) collagen-activated tyrosine kinase receptor signaling pathway
GO:0042060 (involved in) wound healing
GO:0042542 (involved in) response to hydrogen peroxide
GO:0043434 (involved in) response to peptide hormone
GO:0043588 (involved in) skin development
GO:0043589 (involved in) skin morphogenesis
GO:0044344 (involved in) cellular response to fibroblast growth factor stimulus
GO:0044691 (involved in) tooth eruption
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0048545 (involved in) response to steroid hormone
GO:0048705 (involved in) skeletal system morphogenesis
GO:0048706 (involved in) embryonic skeletal system development
GO:0051591 (involved in) response to cAMP
GO:0055093 (involved in) response to hyperoxia
GO:0060325 (involved in) face morphogenesis
GO:0060346 (involved in) bone trabecula formation
GO:0060351 (involved in) cartilage development involved in endochondral bone morphogenesis
GO:0071230 (involved in) cellular response to amino acid stimulus
GO:0071260 (involved in) cellular response to mechanical stimulus
GO:0071300 (involved in) cellular response to retinoic acid
GO:0071306 (involved in) cellular response to vitamin E
GO:0071356 (involved in) cellular response to tumor necrosis factor
GO:0071364 (involved in) cellular response to epidermal growth factor stimulus
GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus
GO:0090263 (involved in) positive regulation of canonical Wnt signaling pathway
GO:1902617 (involved in) response to fluoride
GO:1902618 (involved in) cellular response to fluoride
GO:0005615 (is active in) extracellular space
GO:0005737 (is active in) cytoplasm
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0030141 (located in) secretory granule
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0005581 (part of) collagen trimer
GO:0005584 (part of) collagen type I trimer

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)