Click here to access PB0018 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0018 P08123 Collagen type I alpha 2 chain COL1A2 EDSARTH2, EDSCV, OI4, Collagen alpha-2(I) chain Homo_sapiens Type I collagen is a member of group I collagen (fibrillar forming collagen).

DomainsGene Ontology
PF01391 (6_Collagen)
PF01410 (COLFI)
GO:0002020 (enables) protease binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0030674 (enables) protein-macromolecule adaptor activity
GO:0042802 (enables) identical protein binding
GO:0046332 (enables) SMAD binding
GO:0046872 (enables) metal ion binding
GO:0048407 (enables) platelet-derived growth factor binding
GO:0001501 (involved in) skeletal system development
GO:0001568 (involved in) blood vessel development
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0007266 (involved in) Rho protein signal transduction
GO:0008217 (involved in) regulation of blood pressure
GO:0030198 (involved in) extracellular matrix organization
GO:0030199 (involved in) collagen fibril organization
GO:0030282 (involved in) bone mineralization
GO:0032963 (involved in) collagen metabolic process
GO:0042476 (involved in) odontogenesis
GO:0043589 (involved in) skin morphogenesis
GO:0070208 (involved in) protein heterotrimerization
GO:0071230 (involved in) cellular response to amino acid stimulus
GO:0085029 (involved in) extracellular matrix assembly
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0070062 (located in) extracellular exosome
GO:0005581 (part of) collagen trimer
GO:0005584 (part of) collagen type I trimer
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)