Click here to access PB0016 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0016 P62805 H4 clustered histone 1 H4C1 HIST1H4A, Histone H4, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4FA, H4-16, H4C11, H4C12, H4C13, H4C14, H4C15 Homo_sapiens Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

DomainsGene Ontology
PF15511 (CENP-T_C)
GO:0003677 (enables) DNA binding
GO:0003723 (enables) RNA binding
GO:0005515 (enables) protein binding
GO:0019904 (enables) protein domain specific binding
GO:0046982 (enables) protein heterodimerization activity
GO:0006334 (involved in) nucleosome assembly
GO:0006335 (involved in) DNA replication-dependent chromatin assembly
GO:0006336 (involved in) DNA replication-independent chromatin assembly
GO:0006352 (involved in) DNA-templated transcription, initiation
GO:0032200 (involved in) telomere organization
GO:0045653 (involved in) negative regulation of megakaryocyte differentiation
GO:0000228 (located in) nuclear chromosome
GO:0000781 (located in) chromosome, telomeric region
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0005654 (located in) nucleoplasm
GO:0005694 (located in) chromosome
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome
GO:0000786 (part of) nucleosome
GO:0032991 (part of) protein-containing complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)