Click here to access PB0015 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0015 P28300 Protein-lysine 6-oxidase LOX AAT10, lysyl oxidase Homo_sapiens Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.

DomainsGene Ontology
PF01186 (Lysyl_oxidase)
GO:0004720 (enables) protein-lysine 6-oxidase activity
GO:0005507 (enables) copper ion binding
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0016491 (enables) oxidoreductase activity
GO:0016641 (enables) oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0046872 (enables) metal ion binding
GO:0001568 (involved in) blood vessel development
GO:0001649 (involved in) osteoblast differentiation
GO:0001932 (involved in) regulation of protein phosphorylation
GO:0006464 (involved in) cellular protein modification process
GO:0007507 (involved in) heart development
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009725 (involved in) response to hormone
GO:0010468 (involved in) regulation of gene expression
GO:0016202 (involved in) regulation of striated muscle tissue development
GO:0017015 (involved in) regulation of transforming growth factor beta receptor signaling pathway
GO:0018057 (involved in) peptidyl-lysine oxidation
GO:0018158 (involved in) protein oxidation
GO:0030199 (involved in) collagen fibril organization
GO:0030282 (involved in) bone mineralization
GO:0030324 (involved in) lung development
GO:0035791 (involved in) platelet-derived growth factor receptor-beta signaling pathway
GO:0035904 (involved in) aorta development
GO:0035905 (involved in) ascending aorta development
GO:0035906 (involved in) descending aorta development
GO:0042060 (involved in) wound healing
GO:0042981 (involved in) regulation of apoptotic process
GO:0043491 (involved in) protein kinase B signaling
GO:0045652 (involved in) regulation of megakaryocyte differentiation
GO:0046716 (involved in) muscle cell cellular homeostasis
GO:0048251 (involved in) elastic fiber assembly
GO:0048514 (involved in) blood vessel morphogenesis
GO:0048545 (involved in) response to steroid hormone
GO:0055001 (involved in) muscle cell development
GO:0060326 (involved in) cell chemotaxis
GO:0061448 (involved in) connective tissue development
GO:0071310 (involved in) cellular response to organic substance
GO:0071897 (involved in) DNA biosynthetic process
GO:1900120 (involved in) regulation of receptor binding
GO:1903010 (involved in) regulation of bone development
GO:1990869 (involved in) cellular response to chemokine
GO:2000586 (involved in) regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0031012 (located in) extracellular matrix
GO:0005581 (part of) collagen trimer

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)