Click here to access PB0014 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0014 P24158 Myeloblastin PRTN3 ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3 Homo_sapiens May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).

DomainsGene Ontology
PF00089 (Trypsin)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0019899 (enables) enzyme binding
GO:0006508 (involved in) proteolysis
GO:0006509 (involved in) membrane protein ectodomain proteolysis
GO:0006909 (involved in) phagocytosis
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0019730 (involved in) antimicrobial humoral response
GO:0030574 (involved in) collagen catabolic process
GO:0043547 (involved in) positive regulation of GTPase activity
GO:0045217 (involved in) cell-cell junction maintenance
GO:0050765 (involved in) negative regulation of phagocytosis
GO:0072672 (involved in) neutrophil extravasation
GO:0097029 (involved in) mature conventional dendritic cell differentiation
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0035578 (located in) azurophil granule lumen
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0044853 (located in) plasma membrane raft
GO:0045121 (located in) membrane raft
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)