Click here to access PB0013 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0013 P08311 Cathepsin G CTSG CG, CATG Homo_sapiens Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

DomainsGene Ontology
PF00089 (Trypsin)
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0089720 (enables) caspase binding
GO:0002003 (involved in) angiotensin maturation
GO:0006468 (involved in) protein phosphorylation
GO:0006508 (involved in) proteolysis
GO:0006955 (involved in) immune response
GO:0016485 (involved in) protein processing
GO:0019221 (involved in) cytokine-mediated signaling pathway
GO:0019731 (involved in) antibacterial humoral response
GO:0022617 (involved in) extracellular matrix disassembly
GO:0032496 (involved in) response to lipopolysaccharide
GO:0035590 (involved in) purinergic nucleotide receptor signaling pathway
GO:0042742 (involved in) defense response to bacterium
GO:0044267 (involved in) cellular protein metabolic process
GO:0050778 (involved in) positive regulation of immune response
GO:0050829 (involved in) defense response to Gram-negative bacterium
GO:0050830 (involved in) defense response to Gram-positive bacterium
GO:0050832 (involved in) defense response to fungus
GO:0070946 (involved in) neutrophil-mediated killing of gram-positive bacterium
GO:0071222 (involved in) cellular response to lipopolysaccharide
GO:0098786 (involved in) biofilm matrix disassembly
GO:1901731 (involved in) positive regulation of platelet aggregation
GO:0005737 (is active in) cytoplasm
GO:0043231 (is active in) intracellular membrane-bounded organelle
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0009986 (located in) cell surface
GO:0010494 (located in) cytoplasmic stress granule
GO:0016020 (located in) membrane
GO:0030141 (located in) secretory granule
GO:0035578 (located in) azurophil granule lumen
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)