Click here to access PB0012 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0012 P06702 S100 calcium binding protein A9 S100A9 MIF, NIF, P14, CAGB, CFAG, CGLB, L1AG, LIAG, MRP14, 60B8AG, MAC387, S100-A9 Homo_sapiens The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif (PubMed:25417112).

DomainsGene Ontology
PF01023 (S_100)
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008017 (enables) microtubule binding
GO:0008270 (enables) zinc ion binding
GO:0016209 (enables) antioxidant activity
GO:0035662 (enables) Toll-like receptor 4 binding
GO:0046872 (enables) metal ion binding
GO:0048306 (enables) calcium-dependent protein binding
GO:0050544 (enables) arachidonic acid binding
GO:0050786 (enables) RAGE receptor binding
GO:0002376 (involved in) immune system process
GO:0002523 (involved in) leukocyte migration involved in inflammatory response
GO:0002544 (involved in) chronic inflammatory response
GO:0006914 (involved in) autophagy
GO:0006915 (involved in) apoptotic process
GO:0006919 (involved in) activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006935 (involved in) chemotaxis
GO:0006954 (involved in) inflammatory response
GO:0007267 (involved in) cell-cell signaling
GO:0010976 (involved in) positive regulation of neuron projection development
GO:0014002 (involved in) astrocyte development
GO:0018119 (involved in) peptidyl-cysteine S-nitrosylation
GO:0030307 (involved in) positive regulation of cell growth
GO:0030593 (involved in) neutrophil chemotaxis
GO:0032119 (involved in) sequestering of zinc ion
GO:0032496 (involved in) response to lipopolysaccharide
GO:0035425 (involved in) autocrine signaling
GO:0035606 (involved in) peptidyl-cysteine S-trans-nitrosylation
GO:0035821 (involved in) modulation of process of other organism
GO:0042742 (involved in) defense response to bacterium
GO:0045087 (involved in) innate immune response
GO:0045113 (involved in) regulation of integrin biosynthetic process
GO:0050729 (involved in) positive regulation of inflammatory response
GO:0050832 (involved in) defense response to fungus
GO:0051092 (involved in) positive regulation of NF-kappaB transcription factor activity
GO:0051493 (involved in) regulation of cytoskeleton organization
GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070488 (involved in) neutrophil aggregation
GO:0098869 (involved in) cellular oxidant detoxification
GO:2001244 (involved in) positive regulation of intrinsic apoptotic signaling pathway
GO:0005615 (is active in) extracellular space
GO:0005634 (is active in) nucleus
GO:0005737 (is active in) cytoplasm
GO:0005576 (located in) extracellular region
GO:0005654 (located in) nucleoplasm
GO:0005829 (located in) cytosol
GO:0005856 (located in) cytoskeleton
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0030054 (located in) cell junction
GO:0034774 (located in) secretory granule lumen
GO:0070062 (located in) extracellular exosome
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)