Click here to access PB0011 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0011 P04406 Glyceraldehyde-3-phosphate dehydrogenase GAPDH G3PD, GAPD, HEL-S-162eP Homo_sapiens Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).

DomainsGene Ontology
PF00044 (Gp_dh_N)
PF02800 (Gp_dh_C)
GO:0004365 (enables) glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 (enables) protein binding
GO:0008017 (enables) microtubule binding
GO:0016491 (enables) oxidoreductase activity
GO:0016620 (enables) oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016740 (enables) transferase activity
GO:0019828 (enables) aspartic-type endopeptidase inhibitor activity
GO:0035605 (enables) peptidyl-cysteine S-nitrosylase activity
GO:0042802 (enables) identical protein binding
GO:0050661 (enables) NADP binding
GO:0051287 (enables) NAD binding
GO:0097718 (enables) disordered domain specific binding
GO:0000226 (involved in) microtubule cytoskeleton organization
GO:0001819 (involved in) positive regulation of cytokine production
GO:0002376 (involved in) immune system process
GO:0006006 (involved in) glucose metabolic process
GO:0006096 (involved in) glycolytic process
GO:0006417 (involved in) regulation of translation
GO:0006915 (involved in) apoptotic process
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0016241 (involved in) regulation of macroautophagy
GO:0017148 (involved in) negative regulation of translation
GO:0031640 (involved in) killing of cells of other organism
GO:0032481 (involved in) positive regulation of type I interferon production
GO:0035606 (involved in) peptidyl-cysteine S-trans-nitrosylation
GO:0043123 (involved in) positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 (involved in) innate immune response
GO:0050821 (involved in) protein stabilization
GO:0050832 (involved in) defense response to fungus
GO:0051402 (involved in) neuron apoptotic process
GO:0051873 (involved in) killing by host of symbiont cells
GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0071346 (involved in) cellular response to interferon-gamma
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005811 (located in) lipid droplet
GO:0005829 (located in) cytosol
GO:0005856 (located in) cytoskeleton
GO:0005886 (located in) plasma membrane
GO:0015630 (located in) microtubule cytoskeleton
GO:0016020 (located in) membrane
GO:0031965 (located in) nuclear membrane
GO:0031982 (located in) vesicle
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0070062 (located in) extracellular exosome
GO:0097452 (part of) GAIT complex
GO:1990904 (part of) ribonucleoprotein complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)