Click here to access PB0010 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0010 P02792 Ferritin light chain FTL LFTD, NBIA3 Homo_sapiens Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.

DomainsGene Ontology
PF00210 (Ferritin)
GO:0005506 (enables) iron ion binding
GO:0005515 (enables) protein binding
GO:0008198 (enables) ferrous iron binding
GO:0008199 (enables) ferric iron binding
GO:0042802 (enables) identical protein binding
GO:0046872 (enables) metal ion binding
GO:0006826 (involved in) iron ion transport
GO:0006879 (involved in) cellular iron ion homeostasis
GO:0006880 (involved in) intracellular sequestering of iron ion
GO:0055072 (involved in) iron ion homeostasis
GO:0005737 (is active in) cytoplasm
GO:0005576 (located in) extracellular region
GO:0005829 (located in) cytosol
GO:0016020 (located in) membrane
GO:0035578 (located in) azurophil granule lumen
GO:0044754 (located in) autolysosome
GO:0070062 (located in) extracellular exosome
GO:0008043 (part of) intracellular ferritin complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)