Click here to access PB0009 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0009 P36955 Pigment epithelium-derived factor SERPINF1 OI6, OI12, PEDF, EPC-1, PIG35 Homo_sapiens Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

DomainsGene Ontology
PF00079 (Serpin)
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005515 (enables) protein binding
GO:0001822 (involved in) kidney development
GO:0007568 (involved in) aging
GO:0007614 (involved in) short-term memory
GO:0010447 (involved in) response to acidic pH
GO:0010596 (involved in) negative regulation of endothelial cell migration
GO:0010629 (involved in) negative regulation of gene expression
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0010976 (involved in) positive regulation of neuron projection development
GO:0014070 (involved in) response to organic cyclic compound
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0042698 (involved in) ovulation cycle
GO:0046685 (involved in) response to arsenic-containing substance
GO:0050728 (involved in) negative regulation of inflammatory response
GO:0050769 (involved in) positive regulation of neurogenesis
GO:0060041 (involved in) retina development in camera-type eye
GO:0060770 (involved in) negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071279 (involved in) cellular response to cobalt ion
GO:0071300 (involved in) cellular response to retinoic acid
GO:0071333 (involved in) cellular response to glucose stimulus
GO:0071549 (involved in) cellular response to dexamethasone stimulus
GO:1901215 (involved in) negative regulation of neuron death
GO:1901652 (involved in) response to peptide
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0030424 (located in) axon
GO:0042470 (located in) melanosome
GO:0043025 (located in) neuronal cell body
GO:0043203 (located in) axon hillock
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0070062 (located in) extracellular exosome
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)