Click here to access PB0008 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0008 P02743 Serum amyloid P-component APCS SAP, PTX2, HEL-S-92n Homo_sapiens Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

DomainsGene Ontology
PF00354 (Pentaxin)
GO:0001849 (enables) complement component C1q complex binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0030169 (enables) low-density lipoprotein particle binding
GO:0030246 (enables) carbohydrate binding
GO:0042802 (enables) identical protein binding
GO:0046790 (enables) virion binding
GO:0046872 (enables) metal ion binding
GO:0051082 (enables) unfolded protein binding
GO:0002674 (involved in) negative regulation of acute inflammatory response
GO:0006457 (involved in) protein folding
GO:0006953 (involved in) acute-phase response
GO:0006958 (involved in) complement activation, classical pathway
GO:0044793 (involved in) negative regulation by host of viral process
GO:0044869 (involved in) negative regulation by host of viral exo-alpha-sialidase activity
GO:0044871 (involved in) negative regulation by host of viral glycoprotein metabolic process
GO:0045087 (involved in) innate immune response
GO:0045656 (involved in) negative regulation of monocyte differentiation
GO:0046597 (involved in) negative regulation of viral entry into host cell
GO:0048525 (involved in) negative regulation of viral process
GO:0051131 (involved in) chaperone-mediated protein complex assembly
GO:0061045 (involved in) negative regulation of wound healing
GO:1903016 (involved in) negative regulation of exo-alpha-sialidase activity
GO:1903019 (involved in) negative regulation of glycoprotein metabolic process
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)