Click here to access PB0006 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0006 P09486 secreted protein acidic and cysteine rich SPARC ON, ONT, OI17, BM-40 Homo_sapiens Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity.

DomainsGene Ontology
PF00050 (Kazal_1)
PF09289 (FOLN)
PF10591 (SPARC_Ca_bdg)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0046872 (enables) metal ion binding
GO:0050840 (enables) extracellular matrix binding
GO:0001937 (involved in) negative regulation of endothelial cell proliferation
GO:0010595 (involved in) positive regulation of endothelial cell migration
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0022604 (involved in) regulation of cell morphogenesis
GO:0048856 (involved in) anatomical structure development
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0005886 (located in) plasma membrane
GO:0009986 (located in) cell surface
GO:0016363 (located in) nuclear matrix
GO:0031091 (located in) platelet alpha granule
GO:0031092 (located in) platelet alpha granule membrane
GO:0031093 (located in) platelet alpha granule lumen
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0071682 (located in) endocytic vesicle lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)