Click here to access PB0004 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0004 P08493 Matrix Gla protein MGP NTI, GIG36, MGLAP Homo_sapiens Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

DomainsGene Ontology
PF00594 (GLA domain)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008147 (enables) structural constituent of bone
GO:0001502 (involved in) cartilage condensation
GO:0001503 (involved in) ossification
GO:0030154 (involved in) cell differentiation
GO:0030500 (involved in) regulation of bone mineralization
GO:0051216 (involved in) cartilage development
GO:0005576 (located in) extracellular region
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)