Click here to access PB0003 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0003 P00734 Prothrombin F2 PT, THPH1, RPRGL2, coagulation factor II Homo_sapiens Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

DomainsGene Ontology
PF00051 (2_Kringle)
PF00089 (Trypsin)
PF00594 (Gla)
PF09396 (Thrombin_light)
GO:0009897 (colocalizes with) external side of plasma membrane
GO:0062023 (colocalizes with) collagen-containing extracellular matrix
GO:0001530 (enables) lipopolysaccharide binding
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005102 (enables) signaling receptor binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0008201 (enables) heparin binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0070053 (enables) thrombospondin receptor activity
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0006508 (involved in) proteolysis
GO:0006953 (involved in) acute-phase response
GO:0007166 (involved in) cell surface receptor signaling pathway
GO:0007275 (involved in) multicellular organism development
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008360 (involved in) regulation of cell shape
GO:0009611 (involved in) response to wounding
GO:0010468 (involved in) regulation of gene expression
GO:0010544 (involved in) negative regulation of platelet activation
GO:0014068 (involved in) positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 (involved in) platelet activation
GO:0030193 (involved in) regulation of blood coagulation
GO:0030194 (involved in) positive regulation of blood coagulation
GO:0030307 (involved in) positive regulation of cell growth
GO:0032967 (involved in) positive regulation of collagen biosynthetic process
GO:0042730 (involved in) fibrinolysis
GO:0045861 (involved in) negative regulation of proteolysis
GO:0046427 (involved in) positive regulation of receptor signaling pathway via JAK-STAT
GO:0048712 (involved in) negative regulation of astrocyte differentiation
GO:0051281 (involved in) positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 (involved in) regulation of cytosolic calcium ion concentration
GO:0051838 (involved in) cytolysis by host of symbiont cells
GO:0051918 (involved in) negative regulation of fibrinolysis
GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070945 (involved in) neutrophil-mediated killing of gram-negative bacterium
GO:0090218 (involved in) positive regulation of lipid kinase activity
GO:1900016 (involved in) negative regulation of cytokine production involved in inflammatory response
GO:1900182 (involved in) positive regulation of protein localization to nucleus
GO:1900738 (involved in) positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
GO:2000379 (involved in) positive regulation of reactive oxygen species metabolic process
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005796 (located in) Golgi lumen
GO:0005886 (located in) plasma membrane
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)