Click here to access PB0002 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0002 P61769 Beta-2-microglobulin B2M IMD43 Homo_sapiens Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.

DomainsGene Ontology
PF07654 (C1-set)
GO:0003254 (involved in) regulation of membrane depolarization
GO:0019731 (involved in) antibacterial humoral response
GO:0045087 (involved in) innate immune response
GO:0050829 (involved in) defense response to Gram-negative bacterium
GO:0050830 (involved in) defense response to Gram-positive bacterium
GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0071222 (involved in) cellular response to lipopolysaccharide

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)