|Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076).
GO:0035878 (acts upstream of or within) nail development
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0016055 (involved in) Wnt signaling pathway
GO:0030177 (involved in) positive regulation of Wnt signaling pathway
GO:0050896 (involved in) response to stimulus
GO:0005576 (located in) extracellular region
|Open source database system and analysis tools for molecular interaction data.
|An open access resource for human proteins
|InterPro (new pfam)
|InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.