|CRISTIN1, PWTSR, THSD2
|Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720).
|PF15913 (Furin-like_2) PF19028 (TSP1_spondin)
GO:0005102 (enables) signaling receptor binding
GO:0005109 (enables) frizzled binding
GO:0008201 (enables) heparin binding
GO:0001525 (involved in) angiogenesis
GO:0001974 (involved in) blood vessel remodeling
GO:0002040 (involved in) sprouting angiogenesis
GO:0016055 (involved in) Wnt signaling pathway
GO:0030177 (involved in) positive regulation of Wnt signaling pathway
GO:0050896 (involved in) response to stimulus
GO:0060070 (involved in) canonical Wnt signaling pathway
GO:0060670 (involved in) branching involved in labyrinthine layer morphogenesis
GO:0090263 (involved in) positive regulation of canonical Wnt signaling pathway
GO:2000052 (involved in) positive regulation of non-canonical Wnt signaling pathway
GO:2000096 (involved in) positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0005576 (located in) extracellular region
|Open source database system and analysis tools for molecular interaction data.
|An open access resource for human proteins
|InterPro (new pfam)
|InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.