PB0250

DATABASE

Click here to access PB0250 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0250	Q99217	Amelogenin, X isoform	AMELX	AI1E, AIH1, ALGN, AMG, AMGL, AMGX	Homo_sapiens	Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

Domains

Gene Ontology

GO:0005515 (enables) protein binding GO:0008083 (enables) growth factor activity GO:0030345 (enables) structural constituent of tooth enamel GO:0042802 (enables) identical protein binding GO:0046848 (enables) hydroxyapatite binding GO:0001649 (involved in) osteoblast differentiation GO:0001837 (involved in) epithelial to mesenchymal transition GO:0002062 (involved in) chondrocyte differentiation GO:0007155 (involved in) cell adhesion GO:0007165 (involved in) signal transduction GO:0007584 (involved in) response to nutrient GO:0009410 (involved in) response to xenobiotic stimulus GO:0031214 (involved in) biomineral tissue development GO:0032967 (involved in) positive regulation of collagen biosynthetic process GO:0034505 (involved in) tooth mineralization GO:0042127 (involved in) regulation of cell population proliferation GO:0042475 (involved in) odontogenesis of dentin-containing tooth GO:0051592 (involved in) response to calcium ion GO:0070166 (involved in) enamel mineralization GO:0070172 (involved in) positive regulation of tooth mineralization GO:0097186 (involved in) amelogenesis GO:0005576 (located in) extracellular region GO:0005737 (located in) cytoplasm GO:0005788 (located in) endoplasmic reticulum lumen GO:0005794 (located in) Golgi apparatus GO:0009986 (located in) cell surface GO:0030139 (located in) endocytic vesicle GO:0031012 (located in) extracellular matrix GO:0062023 (located in) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q99217|AMELX_HUMAN Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX PE=1 SV=1 MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQSIRPPYPSYGYEPMGGW LHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLP PPAQQPYQPQPVQPQPHQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWP STDKTKREEVD >sp|Q99217-2|AMELX_HUMAN Isoform 2 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX MGTWILFACLLGAAFAMPVLTPLKWYQSIRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPT HTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQPVQPQP HQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >sp|Q99217-3|AMELX_HUMAN Isoform 3 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLTPLKWYQSIR PPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQ HSMTPIQHHQPNLPPPAQQPYQPQPVQPQPHQPMQPQPPVHPMQPLPPQPPLPPMFPMQP LPPMLPDLTLEAWPSTDKTKREEVD
Selected proteins from model organisms >sp|Q99217|AMELX_HUMAN Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX PE=1 SV=1 MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQSIRPPYPSYGYEPMGGW LHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLP PPAQQPYQPQPVQPQPHQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWP STDKTKREEVD >sp|Q99217-2|AMELX_HUMAN Isoform 2 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX MGTWILFACLLGAAFAMPVLTPLKWYQSIRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPT HTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQPVQPQP HQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >sp|Q99217-3|AMELX_HUMAN Isoform 3 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLTPLKWYQSIR PPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQ HSMTPIQHHQPNLPPPAQQPYQPQPVQPQPHQPMQPQPPVHPMQPLPPQPPLPPMFPMQP LPPMLPDLTLEAWPSTDKTKREEVD >NP_001075447.1 amelogenin, X isoform isoform 1 precursor [Mus musculus] MGTWILFACLLGAAFAMPLPPHPGSPGYINLSYEVLTPLKWYQSMIRQPYPSYGYEPMGGWLHHQIIPVL SQQHPPSHTLQPHHHLPVVPAQQPVAPQQPMMPVPGHHSMTPTQHHQPNIPPSAQQPFQQPFQPQAIPPQ SHQPMQPQSPLHPMQPLAPQPPLPPLFSMQPLSPILPELPLEAWPATDKTKREEVAFSPMKWYQGMTRHP LNMESTTEK >XP_043316138.1 amelogenin, Y isoform [Cervus canadensis] MGTWILFACLWGTAFSMPLPPHPGHPGYVNFSYEVLTPLKWYQNMLRHPYTSYGYEPMGGWLHHQIIPVVSHQSPQNHAL QPHHHIPMVPAQQPMVPQQPMVPVPGQHSMTPIQHHQPNLHLPTQQPFQAQPIQPQPHQPLQPQSPVHPIQPLPPLPPIF PMQPLPPVLPDLPLEAWPATDKTKKEEVVSTP >KAB0372031.1 hypothetical protein FD755_015823 [Muntiacus reevesi] MDGEDQGRINVCWFLFLGHLVLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQN HALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQSIQPQPHQPLQPLQPLQPLQPLQPLQ PQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVDSTKGSNCYFIIR >KAB0344714.1 hypothetical protein FD754_021640 [Muntiacus muntjak] MDGEDQGRINVCWFLFLGHLVLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQN HALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQSIQPQPHQPLQPLQPLQPLQPLQPLQ PQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVDSTKGSNCYFIIQ >ALB35200.1 amelogenin isoform 2 [Oryctolagus cuniculus] MGGAWMLFACLVGAAVALPLPPHPGHPGYINFSYEVLTPLKWYQSLGRPQYPAYAYEPAGAWLHHQVVPVLSAPPPAGPA LQPQLHLPAAPPPAPPTLPQQPLLPAHHHGHAHGHAPAAAPPQRAPAPPPAFAGLQPLPPLPAYPVQPLPPLLPDLPLEA WAATDKTKREEVD >NP_001079152.1 amelogenin X-linked L homeolog precursor [Xenopus laevis] MRPWLMLTALIGVAFSVPLPPHPQHPGYVNFSYEILSPLKWYQSMMTHQYPNYGYEPVSGWLQNPIIPAPPMMPQQQQNA VPKLPPHHPLLIPQHPLVPVPVHHPVFPLIPQHTHQLKPTYLSNPDGQYPTNTQPDNQNGKPIFPLQPMPPLVEDRPQEP WQAAGNTKQEELD >NP_001014984.1 amelogenin, X isoform precursor [Bos taurus] MGTWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVVSQQTPQNHAL QPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQSIQPQPHQPLQPHQPLQPMQPMQPLQPLQ PLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVD >NP_001258003.1 amelogenin, X isoform isoform 1 precursor [Rattus norvegicus] MGTWILFACLLGAAFAMPLPPHPGSPGYINLSYEVLTPLKWYQSMIRQPYPSYGYEPMGGWLHHQIIPVL SQQHPPSHTLQPHHHLPVVPAQQPVAPQQPMMPVPGHHSMTPTQHHQPNIPPSAQQPFQQPFQPQAIPPQ SHQPMQPQSPLHPMQPLAPQPPLPPLFSMQPLSPILPELPLEAWPATDKTKREEVAFSPMKWYQGTARHP LNMETTTEK >XP_020935152.1 amelogenin isoform X1 [Sus scrofa] MGTWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQNMIRHPYTSYGYEPMGGWLHHQIIPVV SQQTPQSHALQPHHHIPMVPAQQPGIPQQPMMPLPGQHSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQP LQPQSPMHPIQPLLPQPPLPPMFSMQSLLPDLPLEAWPATDKTKREEVVSIP >XP_009437023.1 amelogenin, X isoform isoform X1 [Pan troglodytes] MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQSIRPPYPSYGYEPMGGWLHHQIIPVLS QQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQPVQPQPHQPM QPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVVSIF >XP_022271308.2 amelogenin, X isoform [Canis lupus familiaris] MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQNMIRHPYPSYGYEPMGGWLHHQIIPVL SQQNPSNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQP IQPQPPVHPIQPLPPQPPLPPMFPIQPLPPMLPDLPLEAWPATDKTKREEVD >NP_001272545.1 amelogenin, X isoform precursor [Capra hircus] MGTWILFACLLGAAFSMPLPPHPGHPGYINFSYEVPTPLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVV SQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQSIQPQHHQP LQPLQPMQPLQPLQPLQPQPPVHPIQPLPPQPPLLPIFPMQHLPPMIPDVLLEDWPATDKTKREEVD >XP_003805726.1 amelogenin, X isoform [Pan paniscus] MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLTPLKWYQSIRPPYPSYGYEP MGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQP YQPQPVQPQHHQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >XP_004000311.1 amelogenin, X isoform isoform X1 [Felis catus] MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQNMIRHPYPSYGYEPMGGWLHHQIIPVL SQQNPPNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQP IQPQPPVHPIQPLPPQPPLPPMFPIQPLPPMLPDLPLEAWPATDKTKREEVD >XP_011961603.1 amelogenin, X isoform [Ovis aries] MGTWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVV SQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQSIQPQPHQP LQPLQPMQPLQPLQPLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVVSIP >XP_004063828.1 amelogenin, X isoform isoform X1 [Gorilla gorilla gorilla] MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLTPLKWYQSIRPPYPSYGYEP MGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQP YQPQPVQPQPHQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >XP_006022371.1 amelogenin, X isoform [Alligator sinensis] MEGWMLITCLLGATFAIPLPPHPHHPGYVNFSYEVLTPLKWYQSLMRQPYSSYGYEPMGGWLHQPMLPIA QQHPPIQTLTPHHQIPFLSPQHPLMQMPGPHQMMPIPQQQPSLQMPVQEPVQPQAGEHPSPPLQPQQPGH PNPPMQPQLPGSPHPPMQPQQPGIPNPPMYPMQPLPPLLPDMPLEPWRPMDKTKQEEID >XP_014463267.1 PREDICTED: amelogenin, X isoform [Alligator mississippiensis] MEGWMLITCLLGATFAIPVPPHPHHPGYVNFSYEVLTPLKWYQSLMRQPYSSYGYEPMGGWLHQPMLPIA QQHPPIQTLTPHHQIPFLSPQHPLMQMPGPHQMMPIPQQQPSLQMPVQEPVQPQAGEHPSPPLQPQQPGH PNPPMQPQLPGSPHPPMQPQQPGIPNPPMYPMQPLPPLLPDMPLEPWRPMDKTKQEEID >XP_024096475.1 amelogenin, X isoform isoform X1 [Pongo abelii] MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLTPLKWYQSIRPPYPSYGYEP MGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPTQHHQPNLLPPAQQP YQPQPVQPQPHQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >XP_020767239.1 amelogenin, X isoform [Odocoileus virginianus texanus] MGTWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVV SQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQSIQPQPHQP LQPLQPLQPLQPLQPLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVD >XP_040192442.1 amelogenin, X isoform [Rana temporaria] MKSWIILTSLIGAAFCLPLPPHPQHPGYVNLSYEILTPLKWYQSMMKHQYPSFGYEPMSGWLQNSMIPSP MMPQQQLPHPHAIPKLPPHHSVLIPQQPMIPLSPHHPLLPFAPPQANPLNPTYLTNPESQYPTNTQPIEL PKPDILNKPGQPLFPIQPQPPLVEERQHEPWQPLSKTKQNQEELD
Mafft alignment of selected proteins >sp|Q99217|AMELX_HUMAN Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX PE=1 SV=1 MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYE--------------VLT PLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQP---HHHIPVV-PAQQ PVIPQQPMMPVPGQHSMTPIQHHQPNLP----PPAQQPYQPQ-------PVQP------Q PH---------------QPMQPQ---PPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLE AWPSTDKTK--REEVD----------------------- >sp|Q99217-2|AMELX_HUMAN Isoform 2 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX MG---------TWILFACLLGAAFAMP------------------------------VLT PLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQP---HHHIPVV-PAQQ PVIPQQPMMPVPGQHSMTPIQHHQPNLP----PPAQQPYQPQ-------PVQP------Q PH---------------QPMQPQ---PPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLE AWPSTDKTK--REEVD----------------------- >sp|Q99217-3|AMELX_HUMAN Isoform 3 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLT PLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQP---HHHIPVV-PAQQ PVIPQQPMMPVPGQHSMTPIQHHQPNLP----PPAQQPYQPQ-------PVQP------Q PH---------------QPMQPQ---PPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLE AWPSTDKTK--REEVD----------------------- >NP_001075447.1 amelogenin, X isoform isoform 1 precursor [Mus musculus] MG---------TWILFACLLGAAFAMPLPPHPGSPGYINLSYE--------------VLT PLKWYQSMIRQPYPSYGYEPMGGWLHHQIIPVLSQQHPPSHTLQP---HHHLPVV-PAQQ PVAPQQPMMPVPGHHSMTPTQHHQPNIPPSAQQPFQQPFQPQ-------AIPP------Q SH---------------QPMQPQ---SPLHPMQPLAPQPPLPPLFSMQPLSPILPELPLE AWPATDKTK--REEVAFSPMKWYQGMTRHPLNMESTTEK >XP_043316138.1 amelogenin, Y isoform [Cervus canadensis] MG---------TWILFACLWGTAFSMPLPPHPGHPGYVNFSYE--------------VLT PLKWYQNMLRHPYTSYGYEPMGGWLHHQIIPVVSHQSPQNHALQP---HHHIPMV-PAQQ PMVPQQPMVPVPGQHSMTPIQHHQPNLH----LPTQQPFQAQ-------PIQP------Q PH---------------QPLQPQ---SPVHPIQPL---PPLPPIFPMQPLPPVLPDLPLE AWPATDKTK--KEEVVSTP-------------------- >KAB0372031.1 hypothetical protein FD755_015823 [Muntiacus reevesi] MDGEDQGRINVCWFLF---LG---HLVLPPHPGHPGYINFSYE--------------VLT PLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------SIQP------Q PHQPLQPLQPLQPLQPLQPLQPQ---PPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLE AWPATDKTK--REEVDSTK-----GSNCYFIIR------ >KAB0344714.1 hypothetical protein FD754_021640 [Muntiacus muntjak] MDGEDQGRINVCWFLF---LG---HLVLPPHPGHPGYINFSYE--------------VLT PLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------SIQP------Q PHQPLQPLQPLQPLQPLQPLQPQ---PPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLE AWPATDKTK--REEVDSTK-----GSNCYFIIQ------ >ALB35200.1 amelogenin isoform 2 [Oryctolagus cuniculus] MGG--------AWMLFACLVGAAVALPLPPHPGHPGYINFSYE--------------VLT PLKWYQSLGRPQYPAYAYEPAGAWLHHQVVPVLSAPPPAGPALQP---QLHLPAAPPPAP PTLPQQPLLPA---HHHGHAHGHAPAAA----PPQRAP------------APP------- --------------------------PAFAGLQPL----PPLPAYPVQPLPPLLPDLPLE AWAATDKTK--REEVD----------------------- >NP_001079152.1 amelogenin X-linked L homeolog precursor [Xenopus laevis] MR---------PWLMLTALIGVAFSVPLPPHPQHPGYVNFSYE--------------ILS PLKWYQSMMTHQYPNYGYEPVSGWLQNPIIPA-----PPMMPQQQ---QNAVPKLPPHHP LLIPQHPLVPVPVHHPVFPLI-----------PQHTHQLKPTY------LSNP------D GQ---------------YPTNTQ---PD---------NQNGKPIFPLQPMPPLVEDRPQE PWQAAGNTK--QEELD----------------------- >NP_001014984.1 amelogenin, X isoform precursor [Bos taurus] MG---------TWILFACLLGAAFSMPLPPHPGHPGYINFSYE--------------VLT PLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVVSQQTPQNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------SIQPQPHQPLQ PHQPLQPMQPMQPLQPLQPLQPQ---PPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLE AWPATDKTK--REEVD----------------------- >NP_001258003.1 amelogenin, X isoform isoform 1 precursor [Rattus norvegicus] MG---------TWILFACLLGAAFAMPLPPHPGSPGYINLSYE--------------VLT PLKWYQSMIRQPYPSYGYEPMGGWLHHQIIPVLSQQHPPSHTLQP---HHHLPVV-PAQQ PVAPQQPMMPVPGHHSMTPTQHHQPNIPPSAQQPFQQPFQPQ-------AIPP------Q SH---------------QPMQPQ---SPLHPMQPLAPQPPLPPLFSMQPLSPILPELPLE AWPATDKTK--REEVAFSPMKWYQGTARHPLNMETTTEK >XP_020935152.1 amelogenin isoform X1 [Sus scrofa] MG---------TWILFACLLGAAFSMPLPPHPGHPGYINFSYE--------------VLT PLKWYQNMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQSHALQP---HHHIPMV-PAQQ PGIPQQPMMPLPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------PVQP------Q PH---------------QPLQPQ---SPMHPIQPLLPQPPLPPMFSMQSL---LPDLPLE AWPATDKTK--REEVVSIP-------------------- >XP_009437023.1 amelogenin, X isoform isoform X1 [Pan troglodytes] MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYE--------------VLT PLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQP---HHHIPVV-PAQQ PVIPQQPMMPVPGQHSMTPIQHHQPNLP----PPAQQPYQPQ-------PVQP------Q PH---------------QPMQPQ---PPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLE AWPSTDKTK--REEVVSIF-------------------- >XP_022271308.2 amelogenin, X isoform [Canis lupus familiaris] MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYE--------------VLT PLKWYQNMIRHPYPSYGYEPMGGWLHHQIIPVLSQQNPSNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------PVQP------Q PH---------------QPIQPQ---PPVHPIQPLPPQPPLPPMFPIQPLPPMLPDLPLE AWPATDKTK--REEVD----------------------- >NP_001272545.1 amelogenin, X isoform precursor [Capra hircus] MG---------TWILFACLLGAAFSMPLPPHPGHPGYINFSYE--------------VPT PLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVVSQQTPQNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------SIQP------Q HHQPLQPLQPMQPLQPLQPLQPQ---PPVHPIQPLPPQPPLLPIFPMQHLPPMIPDVLLE DWPATDKTK--REEVD----------------------- >XP_003805726.1 amelogenin, X isoform [Pan paniscus] MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLT PLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQP---HHHIPVV-PAQQ PVIPQQPMMPVPGQHSMTPIQHHQPNLP----PPAQQPYQPQ-------PVQP------Q HH---------------QPMQPQ---PPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLE AWPSTDKTK--REEVD----------------------- >XP_004000311.1 amelogenin, X isoform isoform X1 [Felis catus] MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYE--------------VLT PLKWYQNMIRHPYPSYGYEPMGGWLHHQIIPVLSQQNPPNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------PVQP------Q PH---------------QPIQPQ---PPVHPIQPLPPQPPLPPMFPIQPLPPMLPDLPLE AWPATDKTK--REEVD----------------------- >XP_011961603.1 amelogenin, X isoform [Ovis aries] MG---------TWILFACLLGAAFSMPLPPHPGHPGYINFSYE--------------VLT PLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVVSQQTPQNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------SIQP------Q PHQPLQPLQPMQPLQPLQPLQPQ---PPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLE AWPATDKTK--REEVVSIP-------------------- >XP_004063828.1 amelogenin, X isoform isoform X1 [Gorilla gorilla gorilla] MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLT PLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQP---HHHIPVV-PAQQ PVIPQQPMMPVPGQHSMTPIQHHQPNLP----PPAQQPYQPQ-------PVQP------Q PH---------------QPMQPQ---PPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLE AWPSTDKTK--REEVD----------------------- >XP_006022371.1 amelogenin, X isoform [Alligator sinensis] ME---------GWMLITCLLGATFAIPLPPHPHHPGYVNFSYE--------------VLT PLKWYQSLMRQPYSSYGYEPMGGWLHQPMLPI-AQQHPPIQTLTP---HHQIPFL----- --SPQHPLMQMPGPHQMMPIPQQQPSLQ----MPVQEPVQPQAGEHPSPPLQPQ--QPGH PN---------------PPMQPQLPGSPHPPMQPQQPGIPNPPMYPMQPLPPLLPDMPLE PWRPMDKTK--QEEID----------------------- >XP_014463267.1 PREDICTED: amelogenin, X isoform [Alligator mississippiensis] ME---------GWMLITCLLGATFAIPVPPHPHHPGYVNFSYE--------------VLT PLKWYQSLMRQPYSSYGYEPMGGWLHQPMLPI-AQQHPPIQTLTP---HHQIPFL----- --SPQHPLMQMPGPHQMMPIPQQQPSLQ----MPVQEPVQPQAGEHPSPPLQPQ--QPGH PN---------------PPMQPQLPGSPHPPMQPQQPGIPNPPMYPMQPLPPLLPDMPLE PWRPMDKTK--QEEID----------------------- >XP_024096475.1 amelogenin, X isoform isoform X1 [Pongo abelii] MG---------TWILFACLLGAAFAMPLPPHPGHPGYINFSYENSHSQAINVDRTALVLT PLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQP---HHHIPVV-PAQQ PVIPQQPMMPVPGQHSMTPTQHHQPNLL----PPAQQPYQPQ-------PVQP------Q PH---------------QPMQPQ---PPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLE AWPSTDKTK--REEVD----------------------- >XP_020767239.1 amelogenin, X isoform [Odocoileus virginianus texanus] MG---------TWILFACLLGAAFSMPLPPHPGHPGYINFSYE--------------VLT PLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQNHALQP---HHHIPMV-PAQQ PVVPQQPMMPVPGQHSMTPTQHHQPNLP----LPAQQPFQPQ-------SIQP------Q PHQPLQPLQPLQPLQPLQPLQPQ---PPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLE AWPATDKTK--REEVD----------------------- >XP_040192442.1 amelogenin, X isoform [Rana temporaria] MK---------SWIILTSLIGAAFCLPLPPHPQHPGYVNLSYE--------------ILT PLKWYQSMMKHQYPSFGYEPMSGWLQNSMIPS------PMMPQQQLPHPHAIPKLPPHHS VLIPQQPMIPLSPHHPLLPFA-----------PPQANPLNPTY------LTNP------E SQ---------------YPTNTQ---PIELP-KPDILNKPGQPLFPIQPQPPLVEERQHE PWQPLSKTKQNQEELD-----------------------
BMGE Cleaned alignment of selected proteins >sp|Q99217|AMELX_HUMAN Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX PE=1 SV=1 TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >sp|Q99217-2|AMELX_HUMAN Isoform 2 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX TWILFACLLGAAFAMP----------------VLTPLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >sp|Q99217-3|AMELX_HUMAN Isoform 3 of Amelogenin, X isoform OS=Homo sapiens OX=9606 GN=AMELX TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >NP_001075447.1 amelogenin, X isoform isoform 1 precursor [Mus musculus] TWILFACLLGAAFAMPLPPHPGSPGYINLSYEVLTPLKWYQSMIRQPYPSYGYEPMGGWLHHQIIPVLSQQHPPSHTLQPHHHLPVVPAQQPVAPQQPMMPVPGHHSMTPTQHHQPNIPQPFQQPFQPQQPMQPQSPLHPMQPLAPQPPLPPLFSMQPLSPILPELPLEAWPATDKTKREEVA >XP_043316138.1 amelogenin, Y isoform [Cervus canadensis] TWILFACLWGTAFSMPLPPHPGHPGYVNFSYEVLTPLKWYQNMLRHPYTSYGYEPMGGWLHHQIIPVVSHQSPQNHALQPHHHIPMVPAQQPMVPQQPMVPVPGQHSMTPIQHHQPNLHLPTQQPFQAQQPLQPQSPVHPIQPL---PPLPPIFPMQPLPPVLPDLPLEAWPATDKTKKEEVV >KAB0372031.1 hypothetical protein FD755_015823 [Muntiacus reevesi] CWFLF---LG---HLVLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVD >KAB0344714.1 hypothetical protein FD754_021640 [Muntiacus muntjak] CWFLF---LG---HLVLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVD >ALB35200.1 amelogenin isoform 2 [Oryctolagus cuniculus] AWMLFACLVGAAVALPLPPHPGHPGYINFSYEVLTPLKWYQSLGRPQYPAYAYEPAGAWLHHQVVPVLSAPPPAGPALQPQLHLPAAPPAPPTLPQQPLLPA---HHHGHAHGHAPAAAPPQRAP----------PAFAGLQPL----PPLPAYPVQPLPPLLPDLPLEAWAATDKTKREEVD >NP_001079152.1 amelogenin X-linked L homeolog precursor [Xenopus laevis] PWLMLTALIGVAFSVPLPPHPQHPGYVNFSYEILSPLKWYQSMMTHQYPNYGYEPVSGWLQNPIIPA-----PPMMPQQQQNAVPKLPHHPLLIPQHPLVPVPVHHPVFPLI-------PQHTHQLKPTYPTNTQPD---------NQNGKPIFPLQPMPPLVEDRPQEPWQAAGNTKQEELD >NP_001014984.1 amelogenin, X isoform precursor [Bos taurus] TWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVVSQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVD >NP_001258003.1 amelogenin, X isoform isoform 1 precursor [Rattus norvegicus] TWILFACLLGAAFAMPLPPHPGSPGYINLSYEVLTPLKWYQSMIRQPYPSYGYEPMGGWLHHQIIPVLSQQHPPSHTLQPHHHLPVVPAQQPVAPQQPMMPVPGHHSMTPTQHHQPNIPQPFQQPFQPQQPMQPQSPLHPMQPLAPQPPLPPLFSMQPLSPILPELPLEAWPATDKTKREEVA >XP_020935152.1 amelogenin isoform X1 [Sus scrofa] TWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQNMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQSHALQPHHHIPMVPAQQPGIPQQPMMPLPGQHSMTPTQHHQPNLPLPAQQPFQPQQPLQPQSPMHPIQPLLPQPPLPPMFSMQSL---LPDLPLEAWPATDKTKREEVV >XP_009437023.1 amelogenin, X isoform isoform X1 [Pan troglodytes] TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVV >XP_022271308.2 amelogenin, X isoform [Canis lupus familiaris] TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQNMIRHPYPSYGYEPMGGWLHHQIIPVLSQQNPSNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPIQPQPPVHPIQPLPPQPPLPPMFPIQPLPPMLPDLPLEAWPATDKTKREEVD >NP_001272545.1 amelogenin, X isoform precursor [Capra hircus] TWILFACLLGAAFSMPLPPHPGHPGYINFSYEVPTPLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVVSQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPLQPQPPVHPIQPLPPQPPLLPIFPMQHLPPMIPDVLLEDWPATDKTKREEVD >XP_003805726.1 amelogenin, X isoform [Pan paniscus] TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >XP_004000311.1 amelogenin, X isoform isoform X1 [Felis catus] TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQNMIRHPYPSYGYEPMGGWLHHQIIPVLSQQNPPNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPIQPQPPVHPIQPLPPQPPLPPMFPIQPLPPMLPDLPLEAWPATDKTKREEVD >XP_011961603.1 amelogenin, X isoform [Ovis aries] TWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYPSYGYEPMGGWLHHQIIPVVSQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVV >XP_004063828.1 amelogenin, X isoform isoform X1 [Gorilla gorilla gorilla] TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPIQHHQPNLPPPAQQPYQPQQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >XP_006022371.1 amelogenin, X isoform [Alligator sinensis] GWMLITCLLGATFAIPLPPHPHHPGYVNFSYEVLTPLKWYQSLMRQPYSSYGYEPMGGWLHQPMLPI-AQQHPPIQTLTPHHQIPFL------SPQHPLMQMPGPHQMMPIPQQQPSLQMPVQEPVQPQPPMQPQSPHPPMQPQQPGIPNPPMYPMQPLPPLLPDMPLEPWRPMDKTKQEEID >XP_014463267.1 PREDICTED: amelogenin, X isoform [Alligator mississippiensis] GWMLITCLLGATFAIPVPPHPHHPGYVNFSYEVLTPLKWYQSLMRQPYSSYGYEPMGGWLHQPMLPI-AQQHPPIQTLTPHHQIPFL------SPQHPLMQMPGPHQMMPIPQQQPSLQMPVQEPVQPQPPMQPQSPHPPMQPQQPGIPNPPMYPMQPLPPLLPDMPLEPWRPMDKTKQEEID >XP_024096475.1 amelogenin, X isoform isoform X1 [Pongo abelii] TWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQS-IRPPYPSYGYEPMGGWLHHQIIPVLSQQHPPTHTLQPHHHIPVVPAQQPVIPQQPMMPVPGQHSMTPTQHHQPNLLPPAQQPYQPQQPMQPQPPVHPMQPLPPQPPLPPMFPMQPLPPMLPDLTLEAWPSTDKTKREEVD >XP_020767239.1 amelogenin, X isoform [Odocoileus virginianus texanus] TWILFACLLGAAFSMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRHPYTSYGYEPMGGWLHHQIIPVVSQQTPQNHALQPHHHIPMVPAQQPVVPQQPMMPVPGQHSMTPTQHHQPNLPLPAQQPFQPQQPLQPQPPVHPIQPLPPQPPLPPIFPMQPLPPMLPDLPLEAWPATDKTKREEVD >XP_040192442.1 amelogenin, X isoform [Rana temporaria] SWIILTSLIGAAFCLPLPPHPQHPGYVNLSYEILTPLKWYQSMMKHQYPSFGYEPMSGWLQNSMIPS------PMMPQQQPHAIPKLPHHSVLIPQQPMIPLSPHHPLLPFA-------PPQANPLNPTYPTNTQPIELP-KPDILNKPGQPLFPIQPQPPLVEERQHEPWQPLSKTKQEELD
PhyML tree of selected proteins (NP_001079152_1_amelogenin_X_linked_L_homeolog_precursor__Xenopus_laevis_:0.29691647,XP_040192442_1_amelogenin__X_isoform__Rana_temporaria_:0.19469805,(((NP_001075447_1_amelogenin__X_isoform_isoform_1_precursor__Mus_musculus_:0.00000001,NP_001258003_1_amelogenin__X_isoform_isoform_1_precursor__Rattus_norvegicus_:0.00000001):0.11900369,((ALB35200_1_amelogenin_isoform_2__Oryctolagus_cuniculus_:0.67007763,(XP_024096475_1_amelogenin__X_isoform_isoform_X1__Pongo_abelii_:0.00597791,((XP_003805726_1_amelogenin__X_isoform__Pan_paniscus_:0.00000001,(sp_Q99217_3_AMELX_HUMAN_Isoform_3_of_Amelogenin__X_isoform_OS_Homo_sapiens_OX_9606_GN_AMELX:0.00000001,(sp_Q99217_AMELX_HUMAN_Amelogenin__X_isoform_OS_Homo_sapiens_OX_9606_GN_AMELX_PE_1_SV_1:0.00000001,XP_004063828_1_amelogenin__X_isoform_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001,(XP_009437023_1_amelogenin__X_isoform_isoform_X1__Pan_troglodytes_:0.00608188,sp_Q99217_2_AMELX_HUMAN_Isoform_2_of_Amelogenin__X_isoform_OS_Homo_sapiens_OX_9606_GN_AMELX:0.00000001):0.00000001):0.00599479):0.01786792):0.01488476,(((XP_011961603_1_amelogenin__X_isoform__Ovis_aries_:0.00000001,(XP_043316138_1_amelogenin__Y_isoform__Cervus_canadensis_:0.08634112,XP_020935152_1_amelogenin_isoform_X1__Sus_scrofa_:0.05419775):0.02371238):0.00601126,((XP_020767239_1_amelogenin__X_isoform__Odocoileus_virginianus_texanus_:0.00000001,(KAB0372031_1_hypothetical_protein_FD755_015823__Muntiacus_reevesi_:0.00000001,KAB0344714_1_hypothetical_protein_FD754_021640__Muntiacus_muntjak_:0.00000001):0.03117527):0.00588059,(NP_001272545_1_amelogenin__X_isoform_precursor__Capra_hircus_:0.04227962,NP_001014984_1_amelogenin__X_isoform_precursor__Bos_taurus_:0.00000001):0.00000001):0.00000001):0.03434358,(XP_022271308_2_amelogenin__X_isoform__Canis_lupus_familiaris_:0.00591145,XP_004000311_1_amelogenin__X_isoform_isoform_X1__Felis_catus_:0.00000001):0.01624933):0.04319277):0.00000001):0.29420582,(XP_014463267_1_PREDICTED__amelogenin__X_isoform__Alligator_mississippiensis_:0.0060886,XP_006022371_1_amelogenin__X_isoform__Alligator_sinensis_:0.00000001):0.27882849):0.72027581);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)