Click here to access PB0249 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0249 P21815 Bone sialoprotein 2 IBSP BNSP, BSP, BSP-II, SP-II, integrin binding sialoprotein Homo_sapiens Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

DomainsGene Ontology
PF05432 (BSP_II)
GO:0003674 (enables) molecular_function
GO:0005178 (enables) integrin binding
GO:0005515 (enables) protein binding
GO:0001503 (involved in) ossification
GO:0001649 (involved in) osteoblast differentiation
GO:0007155 (involved in) cell adhesion
GO:0030198 (involved in) extracellular matrix organization
GO:0030282 (involved in) bone mineralization
GO:0031214 (involved in) biomineral tissue development
GO:0045785 (involved in) positive regulation of cell adhesion
GO:0071363 (involved in) cellular response to growth factor stimulus
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0016020 (located in) membrane
GO:0031982 (located in) vesicle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)