PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0247 | Q96AC1 | Fermitin family homolog 2 | FERMT2 | KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2 | Homo_sapiens | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
Domains | Gene Ontology |
PF00169 (PH) PF00373 (FERM_M) PF18124 (Kindlin_2_N) |
GO:1902414 (acts upstream of or within) protein localization to cell junction
GO:0003779 (enables) actin binding GO:0005178 (enables) integrin binding GO:0005515 (enables) protein binding GO:0005547 (enables) phosphatidylinositol-3,4,5-trisphosphate binding GO:0008289 (enables) lipid binding GO:0019901 (enables) protein kinase binding GO:0034713 (enables) type I transforming growth factor beta receptor binding GO:0046332 (enables) SMAD binding GO:0051015 (enables) actin filament binding GO:0007155 (involved in) cell adhesion GO:0007160 (involved in) cell-matrix adhesion GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway GO:0007229 (involved in) integrin-mediated signaling pathway GO:0008360 (involved in) regulation of cell shape GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition GO:0016055 (involved in) Wnt signaling pathway GO:0022604 (involved in) regulation of cell morphogenesis GO:0030335 (involved in) positive regulation of cell migration GO:0033622 (involved in) integrin activation GO:0033625 (involved in) positive regulation of integrin activation GO:0034334 (involved in) adherens junction maintenance GO:0034446 (involved in) substrate adhesion-dependent cell spreading GO:0035505 (involved in) positive regulation of myosin light chain kinase activity GO:0043116 (involved in) negative regulation of vascular permeability GO:0043547 (involved in) positive regulation of GTPase activity GO:0045599 (involved in) negative regulation of fat cell differentiation GO:0045669 (involved in) positive regulation of osteoblast differentiation GO:0048041 (involved in) focal adhesion assembly GO:0051496 (involved in) positive regulation of stress fiber assembly GO:0051894 (involved in) positive regulation of focal adhesion assembly GO:0051897 (involved in) positive regulation of protein kinase B signaling GO:0060173 (involved in) limb development GO:0060548 (involved in) negative regulation of cell death GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade GO:0072657 (involved in) protein localization to membrane GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading GO:1900182 (involved in) positive regulation of protein localization to nucleus GO:1902462 (involved in) positive regulation of mesenchymal stem cell proliferation GO:1903691 (involved in) positive regulation of wound healing, spreading of epidermal cells GO:0030055 (is active in) cell-substrate junction GO:0001725 (located in) stress fiber GO:0005634 (located in) nucleus GO:0005654 (located in) nucleoplasm GO:0005737 (located in) cytoplasm GO:0005829 (located in) cytosol GO:0005856 (located in) cytoskeleton GO:0005886 (located in) plasma membrane GO:0005925 (located in) focal adhesion GO:0005938 (located in) cell cortex GO:0009986 (located in) cell surface GO:0016020 (located in) membrane GO:0031234 (located in) extrinsic component of cytoplasmic side of plasma membrane GO:0031258 (located in) lamellipodium membrane GO:0031674 (located in) I band GO:0042995 (located in) cell projection GO:0070161 (located in) anchoring junction GO:0005912 (part of) adherens junction GO:0030054 (part of) cell junction |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |