PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0245 | P35222 | Catenin beta-1 | CTNNB1 | CTNNB, EVR7, MRD19, NEDSDV, armadillo | Homo_sapiens | Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). |
Domains | Gene Ontology |
PF00514 (4_Arm) |
GO:0010718 (acts upstream of or within) positive regulation of epithelial to mesenchymal transition
GO:0001221 (enables) transcription coregulator binding GO:0003682 (enables) chromatin binding GO:0003713 (enables) transcription coactivator activity GO:0005515 (enables) protein binding GO:0008013 (enables) beta-catenin binding GO:0008022 (enables) protein C-terminus binding GO:0016922 (enables) nuclear receptor binding GO:0019899 (enables) enzyme binding GO:0019901 (enables) protein kinase binding GO:0019903 (enables) protein phosphatase binding GO:0045294 (enables) alpha-catenin binding GO:0045296 (enables) cadherin binding GO:0061629 (enables) RNA polymerase II-specific DNA-binding transcription factor binding GO:0140297 (enables) DNA-binding transcription factor binding GO:1990226 (enables) histone methyltransferase binding GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II GO:0000165 (involved in) MAPK cascade GO:0000209 (involved in) protein polyubiquitination GO:0000578 (involved in) embryonic axis specification GO:0000904 (involved in) cell morphogenesis involved in differentiation GO:0001501 (involved in) skeletal system development GO:0001837 (involved in) epithelial to mesenchymal transition GO:0002052 (involved in) positive regulation of neuroblast proliferation GO:0003266 (involved in) regulation of secondary heart field cardioblast proliferation GO:0003338 (involved in) metanephros morphogenesis GO:0003340 (involved in) negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0007398 (involved in) ectoderm development GO:0007403 (involved in) glial cell fate determination GO:0007405 (involved in) neuroblast proliferation GO:0007507 (involved in) heart development GO:0008104 (involved in) protein localization GO:0008283 (involved in) cell population proliferation GO:0008284 (involved in) positive regulation of cell population proliferation GO:0008285 (involved in) negative regulation of cell population proliferation GO:0008543 (involved in) fibroblast growth factor receptor signaling pathway GO:0009410 (involved in) response to xenobiotic stimulus GO:0009948 (involved in) anterior/posterior axis specification GO:0009950 (involved in) dorsal/ventral axis specification GO:0009953 (involved in) dorsal/ventral pattern formation GO:0009954 (involved in) proximal/distal pattern formation GO:0010463 (involved in) mesenchymal cell proliferation GO:0010468 (involved in) regulation of gene expression GO:0010628 (involved in) positive regulation of gene expression GO:0010629 (involved in) negative regulation of gene expression GO:0016331 (involved in) morphogenesis of embryonic epithelium GO:0016525 (involved in) negative regulation of angiogenesis GO:0021819 (involved in) layer formation in cerebral cortex GO:0021854 (involved in) hypothalamus development GO:0022009 (involved in) central nervous system vasculogenesis GO:0022405 (involved in) hair cycle process GO:0030097 (involved in) hemopoiesis GO:0030154 (involved in) cell differentiation GO:0030182 (involved in) neuron differentiation GO:0030217 (involved in) T cell differentiation GO:0030316 (involved in) osteoclast differentiation GO:0030324 (involved in) lung development GO:0030539 (involved in) male genitalia development GO:0030856 (involved in) regulation of epithelial cell differentiation GO:0030858 (involved in) positive regulation of epithelial cell differentiation GO:0030900 (involved in) forebrain development GO:0030901 (involved in) midbrain development GO:0030902 (involved in) hindbrain development GO:0030997 (involved in) regulation of centriole-centriole cohesion GO:0031016 (involved in) pancreas development GO:0031069 (involved in) hair follicle morphogenesis GO:0031641 (involved in) regulation of myelination GO:0032212 (involved in) positive regulation of telomere maintenance via telomerase GO:0032331 (involved in) negative regulation of chondrocyte differentiation GO:0032968 (involved in) positive regulation of transcription elongation by RNA polymerase II GO:0033077 (involved in) T cell differentiation in thymus GO:0033234 (involved in) negative regulation of protein sumoylation GO:0034332 (involved in) adherens junction organization GO:0035050 (involved in) embryonic heart tube development GO:0035112 (involved in) genitalia morphogenesis GO:0035115 (involved in) embryonic forelimb morphogenesis GO:0035116 (involved in) embryonic hindlimb morphogenesis GO:0036023 (involved in) embryonic skeletal limb joint morphogenesis GO:0036520 (involved in) astrocyte-dopaminergic neuron signaling GO:0042127 (involved in) regulation of cell population proliferation GO:0042129 (involved in) regulation of T cell proliferation GO:0042475 (involved in) odontogenesis of dentin-containing tooth GO:0042733 (involved in) embryonic digit morphogenesis GO:0042981 (involved in) regulation of apoptotic process GO:0043065 (involved in) positive regulation of apoptotic process GO:0043123 (involved in) positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043161 (involved in) proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043410 (involved in) positive regulation of MAPK cascade GO:0043525 (involved in) positive regulation of neuron apoptotic process GO:0043588 (involved in) skin development GO:0044093 (involved in) positive regulation of molecular function GO:0044336 (involved in) canonical Wnt signaling pathway involved in negative regulation of apoptotic process GO:0044338 (involved in) canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044339 (involved in) canonical Wnt signaling pathway involved in osteoblast differentiation GO:0045453 (involved in) bone resorption GO:0045595 (involved in) regulation of cell differentiation GO:0045596 (involved in) negative regulation of cell differentiation GO:0045603 (involved in) positive regulation of endothelial cell differentiation GO:0045667 (involved in) regulation of osteoblast differentiation GO:0045669 (involved in) positive regulation of osteoblast differentiation GO:0045670 (involved in) regulation of osteoclast differentiation GO:0045671 (involved in) negative regulation of osteoclast differentiation GO:0045743 (involved in) positive regulation of fibroblast growth factor receptor signaling pathway GO:0045892 (involved in) negative regulation of DNA-templated transcription GO:0045893 (involved in) positive regulation of DNA-templated transcription GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II GO:0045976 (involved in) negative regulation of mitotic cell cycle, embryonic GO:0048469 (involved in) cell maturation GO:0048489 (involved in) synaptic vesicle transport GO:0048513 (involved in) animal organ development GO:0048538 (involved in) thymus development GO:0048568 (involved in) embryonic organ development GO:0048599 (involved in) oocyte development GO:0048617 (involved in) embryonic foregut morphogenesis GO:0048643 (involved in) positive regulation of skeletal muscle tissue development GO:0048664 (involved in) neuron fate determination GO:0048709 (involved in) oligodendrocyte differentiation GO:0048715 (involved in) negative regulation of oligodendrocyte differentiation GO:0050767 (involved in) regulation of neurogenesis GO:0050768 (involved in) negative regulation of neurogenesis GO:0050808 (involved in) synapse organization GO:0051091 (involved in) positive regulation of DNA-binding transcription factor activity GO:0051145 (involved in) smooth muscle cell differentiation GO:0051450 (involved in) myoblast proliferation GO:0051571 (involved in) positive regulation of histone H3-K4 methylation GO:0051884 (involved in) regulation of timing of anagen GO:0051973 (involved in) positive regulation of telomerase activity GO:0060066 (involved in) oviduct development GO:0060070 (involved in) canonical Wnt signaling pathway GO:0060173 (involved in) limb development GO:0060439 (involved in) trachea morphogenesis GO:0060440 (involved in) trachea formation GO:0060441 (involved in) epithelial tube branching involved in lung morphogenesis GO:0060479 (involved in) lung cell differentiation GO:0060484 (involved in) lung-associated mesenchyme development GO:0060487 (involved in) lung epithelial cell differentiation GO:0060492 (involved in) lung induction GO:0060742 (involved in) epithelial cell differentiation involved in prostate gland development GO:0060767 (involved in) epithelial cell proliferation involved in prostate gland development GO:0060769 (involved in) positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060789 (involved in) hair follicle placode formation GO:0060916 (involved in) mesenchymal cell proliferation involved in lung development GO:0061047 (involved in) positive regulation of branching involved in lung morphogenesis GO:0061198 (involved in) fungiform papilla formation GO:0061324 (involved in) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061549 (involved in) sympathetic ganglion development GO:0061550 (involved in) cranial ganglion development GO:0070602 (involved in) regulation of centromeric sister chromatid cohesion GO:0071681 (involved in) cellular response to indole-3-methanol GO:0072033 (involved in) renal vesicle formation GO:0072053 (involved in) renal inner medulla development GO:0072054 (involved in) renal outer medulla development GO:0072079 (involved in) nephron tubule formation GO:0072089 (involved in) stem cell proliferation GO:0072182 (involved in) regulation of nephron tubule epithelial cell differentiation GO:0072497 (involved in) mesenchymal stem cell differentiation GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway GO:0090425 (involved in) acinar cell differentiation GO:0097091 (involved in) synaptic vesicle clustering GO:0097190 (involved in) apoptotic signaling pathway GO:0098609 (involved in) cell-cell adhesion GO:1901215 (involved in) negative regulation of neuron death GO:1903204 (involved in) negative regulation of oxidative stress-induced neuron death GO:1904796 (involved in) regulation of core promoter binding GO:1904798 (involved in) positive regulation of core promoter binding GO:1904888 (involved in) cranial skeletal system development GO:1904948 (involved in) midbrain dopaminergic neuron differentiation GO:1904954 (involved in) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1990138 (involved in) neuron projection extension GO:1990403 (involved in) embryonic brain development GO:1990791 (involved in) dorsal root ganglion development GO:2000017 (involved in) positive regulation of determination of dorsal identity GO:2000179 (involved in) positive regulation of neural precursor cell proliferation GO:2000288 (involved in) positive regulation of myoblast proliferation GO:2000648 (involved in) positive regulation of stem cell proliferation GO:2001234 (involved in) negative regulation of apoptotic signaling pathway GO:0000791 (located in) euchromatin GO:0005634 (located in) nucleus GO:0005654 (located in) nucleoplasm GO:0005737 (located in) cytoplasm GO:0005813 (located in) centrosome GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0005911 (located in) cell-cell junction GO:0005912 (located in) adherens junction GO:0005916 (located in) fascia adherens GO:0005923 (located in) bicellular tight junction GO:0005925 (located in) focal adhesion GO:0014704 (located in) intercalated disc GO:0016020 (located in) membrane GO:0016323 (located in) basolateral plasma membrane GO:0016327 (located in) apicolateral plasma membrane GO:0016328 (located in) lateral plasma membrane GO:0030018 (located in) Z disc GO:0030027 (located in) lamellipodium GO:0030054 (located in) cell junction GO:0031253 (located in) cell projection membrane GO:0031528 (located in) microvillus membrane GO:0042734 (located in) presynaptic membrane GO:0043296 (located in) apical junction complex GO:0045177 (located in) apical part of cell GO:0045202 (located in) synapse GO:0045211 (located in) postsynaptic membrane GO:0048471 (located in) perinuclear region of cytoplasm GO:0070062 (located in) extracellular exosome GO:0098685 (located in) Schaffer collateral - CA1 synapse GO:0098831 (located in) presynaptic active zone cytoplasmic component GO:0099092 (located in) postsynaptic density, intracellular component GO:0005667 (part of) transcription regulator complex GO:0016342 (part of) catenin complex GO:0016600 (part of) flotillin complex GO:0030877 (part of) beta-catenin destruction complex GO:0032991 (part of) protein-containing complex GO:0034750 (part of) Scrib-APC-beta-catenin complex GO:0070369 (part of) beta-catenin-TCF7L2 complex GO:0090575 (part of) RNA polymerase II transcription regulator complex GO:1990711 (part of) beta-catenin-ICAT complex GO:1990907 (part of) beta-catenin-TCF complex GO:1990909 (part of) Wnt signalosome |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |