Click here to access PB0244 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0244 Q15942 Zyxin ZYX ESP-2, HED-2 Homo_sapiens Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

DomainsGene Ontology
PF00412 (3_LIM)
GO:0003723 (enables) RNA binding
GO:0005515 (enables) protein binding
GO:0046872 (enables) metal ion binding
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0007165 (involved in) signal transduction
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0007267 (involved in) cell-cell signaling
GO:0043149 (involved in) stress fiber assembly
GO:0050727 (involved in) regulation of inflammatory response
GO:0071346 (involved in) cellular response to interferon-gamma
GO:0001725 (located in) stress fiber
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005829 (located in) cytosol
GO:0005856 (located in) cytoskeleton
GO:0005886 (located in) plasma membrane
GO:0005912 (located in) adherens junction
GO:0005925 (located in) focal adhesion
GO:0015629 (located in) actin cytoskeleton
GO:0045335 (located in) phagocytic vesicle
GO:0070161 (located in) anchoring junction

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)