PB0242

DATABASE

Click here to access PB0242 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0242	P02766	Transthyretin	TTR	ATTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA, TTN	Homo_sapiens	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Domains

Gene Ontology

PF00576 (Transthyretin)

GO:0005179 (enables) hormone activity
GO:0005515 (enables) protein binding
GO:0042562 (enables) hormone binding
GO:0042802 (enables) identical protein binding
GO:0044877 (enables) protein-containing complex binding
GO:0070324 (enables) thyroid hormone binding
GO:0006144 (involved in) purine nucleobase metabolic process
GO:0007165 (involved in) signal transduction
GO:0042572 (involved in) retinol metabolic process
GO:0070327 (involved in) thyroid hormone transport
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0035578 (located in) azurophil granule lumen
GO:0070062 (located in) extracellular exosome
GO:0032991 (part of) protein-containing complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)
Selected proteins from model organisms

>NP_036813.2 transthyretin precursor [Rattus norvegicus]
MASLRLFLLCLAGLIFASEAGPGGAGESKCPLMVKVLDAVRGSPAVDVAVKVFKKTADGSWEPFASGKTA
ESGELHGLTTDEKFTEGVYRVELDTKSYWKALGISPFHEYAEVVFTANDSGHRHYTIAALLSPYSYSTTA
VVSNPQN

>NP_776392.1 transthyretin precursor [Bos taurus]
MASFRLFLLCLAGLVFVSEAGSVGAGEPKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTS
ESGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEFAEVVFTANDSGPRHYTIAALLSPYSYSTTA
LVSSPKA

>NP_001268427.1 transthyretin isoform 2 [Gallus gallus]
MICYCWSPCTNFYAWKLNIECYLPLSLLCSGLVFLSEAAPLVSHGSVDSKCPLMVKVLDAVRGSPAANVA
VKVFKKAADGTWQDFATGKTTEFGEIHELTTEEQFVEGVYRVEFDTSSYWKGLGLSPFHEYADVVFTAND
SGHRHYTIAALLSPFSYSTTAVVSDPQE

>NP_999377.1 transthyretin precursor [Sus scrofa]
MASYRLLLLCLAGLVFVSEAGPAGAGESKCPLMVKVLDAVRGSPAVNVGVKVFKKAADGTWEPFALGKTS
EFGELHGLTTDEKFVEGIYKVELDTKSYWKALGISPFHEYAEVVFTANDSGRRHYTIAALLSPYSYSTTA
LVSSPKEGAL

>NP_001009800.1 transthyretin precursor [Ovis aries]
MASFRLLLLCLAGLVFVSEASPAGAGESKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTS
DSGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTA
LVSSPKE

>NP_001005598.2 transthyretin precursor [Danio rerio]
MAKEVICVLLASLFALCRSAPVAFHGGSDAHCPLTVKILDAVKGTPAGNIALDLFRQDQGGTWEKIASGK
VDMTGEVHNLITEQEFTPGVYRVEFDTLTYWKTEGRTPFHQLADVVFEAHAEGHRHYTLALLLSPFSYTT
TAVVVKAHD

>XP_537290.1 transthyretin [Canis lupus familiaris]
MASHRLLLLCLAGLVLVSEASPAGTSGPKCPLMVKVLDAVRGSPAVNVAVKVFKKTADETWEPFASGKTS
EFGELHGLTTVEKFVEGVYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTA
LVSNPKE

>NP_001009137.1 transthyretin precursor [Pan troglodytes]
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFKKAADETWEPFASGKTS
ESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTA
VVTIPKE

>NP_001127064.1 transthyretin precursor [Pongo abelii]
MASHRLLLLCLAGLVFVSEAGPTGAGESKCPLMVKVLDAVRGSPAVNVAVNVFKRAADETWEPFASGKTS
ESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFAANDSGPRRYTIAALLSPYSYSTTA
VVTNPKE

>XP_002713532.1 PREDICTED: transthyretin [Oryctolagus cuniculus]
MASQHLLLLCLAGLVFVSEAGPVGTGDSKCPLMVKVLDAVRGSPAVDVSVHVFKKAADETWEPFASGKTS
KTGELHGLTTSEKFVEGVYKVELDTKSYWKALGISPFHEYAEVVFTANDSGHRSYTIAALLSPFSYSTTA
VVSNPQE

>NP_001278332.1 transthyretin precursor [Meleagris gallopavo]
MAFHSTLLVFLAGLVFLSEAAPLVSHGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKKAADGTWQDFATG
KTTEYGEIHELTTEEQFVEGVYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYS
TTAVVSDPQE

>XP_003830303.2 transthyretin [Pan paniscus]
MASHHLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFKKAADETWEPFASGKTS
ESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTA
VVTIPKE

>NP_001274485.1 transthyretin precursor [Felis catus]
MASHLLLLCLAGLVLVSEAGPAGTGESKCPLMVKVLDAVQGSPAVNVAVKVFKKAADESWEPFASGKTSE
FGELHGLTTAENFVEGVYKVEIDTKSYWKSLGISPFHEYAEVVFTANNSGSRHYTIAALLSPYSYSTTAL
VSSPKE

>XP_004059337.1 transthyretin [Gorilla gorilla gorilla]
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPATNVAVHVFKKGADETWEPFASGKTS
ESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTA
VVTNPKE

>XP_005697069.1 PREDICTED: transthyretin [Capra hircus]
MASFRLLLLCLAGLVFVSEASPAGAGESKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTS
DSGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTA
LVSSPKE

>XP_006016463.1 transthyretin [Alligator sinensis]
MAFQSMLLVFLAGLVFLSEAAPLVSHGSIDSKCPLMVKVLDAVRGSPAANVAIKVFKKTSDGDWQEFAAG
KTTEFGEVHELTSDDKFVEGIYRVEFDTSSYWKALGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYS
TTAVVSDPQE

>XP_006271319.1 PREDICTED: transthyretin [Alligator mississippiensis]
MAFQSMLLVFLAGLVFLSEAAPLVSHGSIDSKCPLMVKVLDAVRGSPAANVAIKVFKKTSDGDWQEFAAG
KTTEFGEVHELTSDDKFVEGIYRVEFDTSSYWKALGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYS
TTAVVSDPQE

>XP_020757674.1 transthyretin [Odocoileus virginianus texanus]
MASFRLFLLCLAGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTS
ESGELHRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTA
LVSSPKE

>XP_030288250.1 transthyretin-like [Sparus aurata]
MLQPLHCLLLASAVLLCNTAPTPTDKHGGSDTRCPLMVKILDAVKGTPAGSVALKVSQKTADGAWTQIAT
GLTDATGEIHNLITEQQFPAGVYRVEFDTKAYWTNQGSTPFHEVAEVVFDAHPEGHRHYTLALLLSPFSY
TTTAVVSSVHE

>XP_040210045.1 transthyretin [Rana temporaria]
MAYYNTLVLLTIFIFSGGFHQAQGTHGEADSKCPLMVKVLDAVRGIPVAKLPVKVFKQNEDKSWGLISSG
TTSSDGEIHNLITEEQFVEGIYKLEFATKRYWSKLGLSPFHEYVDVVFTANDAGHRHYTIAVLLTPYSFS
TTAVVSDLKEIHA
>XP_011682724.1 transthyretin isoform X2 [Strongylocentrotus purpuratus]
MHSGKEPRNMNCAVDDKLYFRKGSRSTSQRVVQASERERLFKEFHDSPSGGHGGLNVTFRKISQRYYWRGLMSYLKIKVK
QCQVCQNRELWPHMKVTSKEQKQAKRKTSLKRTAGGKPNSPLTSHVLDTARGSPAANLRIEVYHLMAGQWKKISEGQTNS
DGRCPGLLTMEQFIPGIYKILFDTGSYFKANNIKGFYPFVEIVFEIEDVNQHYHVPLLLSPFSYSTYRGS

>KAB0363513.1 hypothetical protein FD754_007669 [Muntiacus muntjak]
MASLRLFLLCLAGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTAESGELHRLTT
EDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>XP_043300308.1 transthyretin [Cervus canadensis]
MASFRLFLLCLSGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAADVGVKVFKKAADETWEPFASGKTSESGELHRLTT
EDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>OWK01751.1 TTR [Cervus elaphus hippelaphus]
MASFRLFLLCLSGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAADVGVKVFKKAAEETWEPFASGKTSESGELHRLTT
EDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>XP_005504287.1 transthyretin [Columba livia]
MAFHSVFFVFLAGLVLFSEAAPLVTHGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKKAADGSWQDFAAGKTTEYGEIHD
LTTDEQFVEGIYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYSTTAVVTVPQE
>NP_001081348.1 transthyretin precursor [Xenopus laevis]
MASFKSFLLLALLAIVSEAAPPGHASHGEADSKCPLMVKVLDAVRGIPAANLLVNVFRQTESGKWEQITSGKTTELGEIH
NLTTDEQFTEGVYKIEFATKAFWGKLGLSPFHEYVDVVFTANDAGHRQYTIAVLLTPYSFSSTAIVSEPHDDL
>XP_015808416.1 PREDICTED: transthyretin isoform X2 [Nothobranchius furzeri]
MAGSPSPLTTHVLNTAAGVPGSNMTIKLYQQDSVTKVWQLINTGTTNDDGRCPGLITKQQFIPGEYKMHFETARYWAGMG
ESSFYPYVEIAFTITDADQKYHVPLLVSRFSYSTYRGS

Mafft alignment of selected proteins

>sp|P02766|TTHY_HUMAN Transthyretin OS=Homo sapiens OX=9606 GN=TTR PE=1 SV=1
MASHR------------------LLLLCLAGLVFVSEAGPT-------------------
------------------------------------------------------------
-------GTGESKCPLMVKVLDAVRGSPAINVAVHVFRK-AADDTWEPFASGKTSESGEL
HGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYS
YSTTAVVTNPKE---
>NP_038725.1 transthyretin precursor [Mus musculus]
MASLR------------------LFLLCLAGLVFVSEAGPA-------------------
------------------------------------------------------------
-------GAGESKCPLMVKVLDAVRGSPAVDVAVKVFKK-TSEGSWEPFASGKTAESGEL
HGLTTDEKFVEGVYRVELDTKSYWKTLGISPFHEFADVVFTANDSGHRHYTIAALLSPYS
YSTTAVVSNPQN---
>NP_036813.2 transthyretin precursor [Rattus norvegicus]
MASLR------------------LFLLCLAGLIFASEAGPG-------------------
------------------------------------------------------------
-------GAGESKCPLMVKVLDAVRGSPAVDVAVKVFKK-TADGSWEPFASGKTAESGEL
HGLTTDEKFTEGVYRVELDTKSYWKALGISPFHEYAEVVFTANDSGHRHYTIAALLSPYS
YSTTAVVSNPQN---
>NP_776392.1 transthyretin precursor [Bos taurus]
MASFR------------------LFLLCLAGLVFVSEAGSV-------------------
------------------------------------------------------------
-------GAGEPKCPLMVKVLDAVRGSPAANVGVKVFKK-AADETWEPFASGKTSESGEL
HGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEFAEVVFTANDSGPRHYTIAALLSPYS
YSTTALVSSPKA---
>NP_001268427.1 transthyretin isoform 2 [Gallus gallus]
MICYCWSPCTNFYAWKLNIECYLPLSLLCSGLVFLSEAAPLV------------------
------------------------------------------------------------
-----SHGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKK-AADGTWQDFATGKTTEFGEI
HELTTEEQFVEGVYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFS
YSTTAVVSDPQE---
>NP_999377.1 transthyretin precursor [Sus scrofa]
MASYR------------------LLLLCLAGLVFVSEAGPA-------------------
------------------------------------------------------------
-------GAGESKCPLMVKVLDAVRGSPAVNVGVKVFKK-AADGTWEPFALGKTSEFGEL
HGLTTDEKFVEGIYKVELDTKSYWKALGISPFHEYAEVVFTANDSGRRHYTIAALLSPYS
YSTTALVSSPKEGAL
>NP_001009800.1 transthyretin precursor [Ovis aries]
MASFR------------------LLLLCLAGLVFVSEASPA-------------------
------------------------------------------------------------
-------GAGESKCPLMVKVLDAVRGSPAANVGVKVFKK-AADETWEPFASGKTSDSGEL
HGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYS
YSTTALVSSPKE---
>NP_001005598.2 transthyretin precursor [Danio rerio]
MAKE-------------------VICVLLASLFALCRSAPVA------------------
------------------------------------------------------------
-----FHGGSDAHCPLTVKILDAVKGTPAGNIALDLFRQ-DQGGTWEKIASGKVDMTGEV
HNLITEQEFTPGVYRVEFDTLTYWKTEGRTPFHQLADVVFEAHAEGHRHYTLALLLSPFS
YTTTAVVVKAHD---
>XP_537290.1 transthyretin [Canis lupus familiaris]
MASHR------------------LLLLCLAGLVLVSEASPA-------------------
------------------------------------------------------------
-------GTSGPKCPLMVKVLDAVRGSPAVNVAVKVFKK-TADETWEPFASGKTSEFGEL
HGLTTVEKFVEGVYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYS
YSTTALVSNPKE---
>NP_001009137.1 transthyretin precursor [Pan troglodytes]
MASHR------------------LLLLCLAGLVFVSEAGPT-------------------
------------------------------------------------------------
-------GTGESKCPLMVKVLDAVRGSPAINVAVHVFKK-AADETWEPFASGKTSESGEL
HGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYS
YSTTAVVTIPKE---
>NP_001127064.1 transthyretin precursor [Pongo abelii]
MASHR------------------LLLLCLAGLVFVSEAGPT-------------------
------------------------------------------------------------
-------GAGESKCPLMVKVLDAVRGSPAVNVAVNVFKR-AADETWEPFASGKTSESGEL
HGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFAANDSGPRRYTIAALLSPYS
YSTTAVVTNPKE---
>XP_002713532.1 PREDICTED: transthyretin [Oryctolagus cuniculus]
MASQH------------------LLLLCLAGLVFVSEAGPV-------------------
------------------------------------------------------------
-------GTGDSKCPLMVKVLDAVRGSPAVDVSVHVFKK-AADETWEPFASGKTSKTGEL
HGLTTSEKFVEGVYKVELDTKSYWKALGISPFHEYAEVVFTANDSGHRSYTIAALLSPFS
YSTTAVVSNPQE---
>NP_001278332.1 transthyretin precursor [Meleagris gallopavo]
MAFHS------------------TLLVFLAGLVFLSEAAPLV------------------
------------------------------------------------------------
-----SHGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKK-AADGTWQDFATGKTTEYGEI
HELTTEEQFVEGVYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFS
YSTTAVVSDPQE---
>XP_003830303.2 transthyretin [Pan paniscus]
MASHH------------------LLLLCLAGLVFVSEAGPT-------------------
------------------------------------------------------------
-------GTGESKCPLMVKVLDAVRGSPAINVAVHVFKK-AADETWEPFASGKTSESGEL
HGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYS
YSTTAVVTIPKE---
>NP_001274485.1 transthyretin precursor [Felis catus]
MASH-------------------LLLLCLAGLVLVSEAGPA-------------------
------------------------------------------------------------
-------GTGESKCPLMVKVLDAVQGSPAVNVAVKVFKK-AADESWEPFASGKTSEFGEL
HGLTTAENFVEGVYKVEIDTKSYWKSLGISPFHEYAEVVFTANNSGSRHYTIAALLSPYS
YSTTALVSSPKE---
>XP_004059337.1 transthyretin [Gorilla gorilla gorilla]
MASHR------------------LLLLCLAGLVFVSEAGPT-------------------
------------------------------------------------------------
-------GTGESKCPLMVKVLDAVRGSPATNVAVHVFKK-GADETWEPFASGKTSESGEL
HGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYS
YSTTAVVTNPKE---
>XP_005697069.1 PREDICTED: transthyretin [Capra hircus]
MASFR------------------LLLLCLAGLVFVSEASPA-------------------
------------------------------------------------------------
-------GAGESKCPLMVKVLDAVRGSPAANVGVKVFKK-AADETWEPFASGKTSDSGEL
HGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYS
YSTTALVSSPKE---
>XP_006016463.1 transthyretin [Alligator sinensis]
MAFQS------------------MLLVFLAGLVFLSEAAPLV------------------
------------------------------------------------------------
-----SHGSIDSKCPLMVKVLDAVRGSPAANVAIKVFKK-TSDGDWQEFAAGKTTEFGEV
HELTSDDKFVEGIYRVEFDTSSYWKALGLSPFHEYADVVFTANDSGHRHYTIAALLSPFS
YSTTAVVSDPQE---
>XP_006271319.1 PREDICTED: transthyretin [Alligator mississippiensis]
MAFQS------------------MLLVFLAGLVFLSEAAPLV------------------
------------------------------------------------------------
-----SHGSIDSKCPLMVKVLDAVRGSPAANVAIKVFKK-TSDGDWQEFAAGKTTEFGEV
HELTSDDKFVEGIYRVEFDTSSYWKALGLSPFHEYADVVFTANDSGHRHYTIAALLSPFS
YSTTAVVSDPQE---
>XP_020757674.1 transthyretin [Odocoileus virginianus texanus]
MASFR------------------LFLLCLAGLVFVSEAGPP-------------------
------------------------------------------------------------
-------GAGEPKCPLMVKVLDAVRGSPAANVGVKVFKK-AADETWEPFASGKTSESGEL
HRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYS
YSTTALVSSPKE---
>XP_030288250.1 transthyretin-like [Sparus aurata]
MLQP-------------------LHCLLLASAVLLCNTAPTPT-----------------
------------------------------------------------------------
----DKHGGSDTRCPLMVKILDAVKGTPAGSVALKVSQK-TADGAWTQIATGLTDATGEI
HNLITEQQFPAGVYRVEFDTKAYWTNQGSTPFHEVAEVVFDAHPEGHRHYTLALLLSPFS
YTTTAVVSSVHE---
>XP_040210045.1 transthyretin [Rana temporaria]
MAYYN------------------TLVLLTIFIF--SGGFHQAQ-----------------
------------------------------------------------------------
----GTHGEADSKCPLMVKVLDAVRGIPVAKLPVKVFKQ-NEDKSWGLISSGTTSSDGEI
HNLITEEQFVEGIYKLEFATKRYWSKLGLSPFHEYVDVVFTANDAGHRHYTIAVLLTPYS
FSTTAVVSDLKEIHA
>XP_011682724.1 transthyretin isoform X2 [Strongylocentrotus purpuratus]
MHSGK-EPRN-------------MNCAVDDKLYFRKGSRSTSQRVVQASERERLFKEFHD
SPSGGHGGLNVTFRKISQRYYWRGLMSYLKIKVKQCQVCQNRELWPHMKVTSKEQKQAKR
KTSLKRTAGGKPNSPLTSHVLDTARGSPAANLRIEVYHL--MAGQWKKISEGQTNSDGRC
PGLLTMEQFIPGIYKILFDTGSYFKANNIKGFYPFVEIVFEIEDV-NQHYHVPLLLSPFS
YSTYRGS--------
>KAB0363513.1 hypothetical protein FD754_007669 [Muntiacus muntjak]
MASLR------------------LFLLCLAGLVFVSEAGPP-------------------
------------------------------------------------------------
-------GAGEPKCPLMVKVLDAVRGSPAANVGVKVFKK-AADETWEPFASGKTAESGEL
HRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYS
YSTTALVSSPKE---
>XP_043300308.1 transthyretin [Cervus canadensis]
MASFR------------------LFLLCLSGLVFVSEAGPP-------------------
------------------------------------------------------------
-------GAGEPKCPLMVKVLDAVRGSPAADVGVKVFKK-AADETWEPFASGKTSESGEL
HRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYS
YSTTALVSSPKE---
>OWK01751.1 TTR [Cervus elaphus hippelaphus]
MASFR------------------LFLLCLSGLVFVSEAGPP-------------------
------------------------------------------------------------
-------GAGEPKCPLMVKVLDAVRGSPAADVGVKVFKK-AAEETWEPFASGKTSESGEL
HRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYS
YSTTALVSSPKE---
>XP_005504287.1 transthyretin [Columba livia]
MAFHS------------------VFFVFLAGLVLFSEAAPLV------------------
------------------------------------------------------------
-----THGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKK-AADGSWQDFAAGKTTEYGEI
HDLTTDEQFVEGIYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFS
YSTTAVVTVPQE---
>NP_001081348.1 transthyretin precursor [Xenopus laevis]
MASFK------------------SFLL-LALLAIVSEAAPPGH-----------------
------------------------------------------------------------
----ASHGEADSKCPLMVKVLDAVRGIPAANLLVNVFRQ-TESGKWEQITSGKTTELGEI
HNLTTDEQFTEGVYKIEFATKAFWGKLGLSPFHEYVDVVFTANDAGHRQYTIAVLLTPYS
FSSTAIVSEPHD-DL
>XP_015808416.1 PREDICTED: transthyretin isoform X2 [Nothobranchius furzeri]
M-----------------------------------------------------------
------------------------------------------------------------
---------AGSPSPLTTHVLNTAAGVPGSNMTIKLYQQDSVTKVWQLINTGTTNDDGRC
PGLITKQQFIPGEYKMHFETARYWAGMGESSFYPYVEIAFTITDA-DQKYHVPLLVSRFS
YSTYRGS--------

BMGE Cleaned alignment of selected proteins

>sp|P02766|TTHY_HUMAN Transthyretin OS=Homo sapiens OX=9606 GN=TTR PE=1 SV=1
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
>NP_038725.1 transthyretin precursor [Mus musculus]
MASLRLFLLCLAGLVFVSEAGPAGAGESKCPLMVKVLDAVRGSPAVDVAVKVFKKTSEGSWEPFASGKTAESGELHGLTTDEKFVEGVYRVELDTKSYWKTLGISPFHEFADVVFTANDSGHRHYTIAALLSPYSYSTTAVVSNPQN
>NP_036813.2 transthyretin precursor [Rattus norvegicus]
MASLRLFLLCLAGLIFASEAGPGGAGESKCPLMVKVLDAVRGSPAVDVAVKVFKKTADGSWEPFASGKTAESGELHGLTTDEKFTEGVYRVELDTKSYWKALGISPFHEYAEVVFTANDSGHRHYTIAALLSPYSYSTTAVVSNPQN
>NP_776392.1 transthyretin precursor [Bos taurus]
MASFRLFLLCLAGLVFVSEAGSVGAGEPKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTSESGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEFAEVVFTANDSGPRHYTIAALLSPYSYSTTALVSSPKA
>NP_001268427.1 transthyretin isoform 2 [Gallus gallus]
MICYCPLSLLCSGLVFLSEAAPLGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKKAADGTWQDFATGKTTEFGEIHELTTEEQFVEGVYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYSTTAVVSDPQE
>NP_999377.1 transthyretin precursor [Sus scrofa]
MASYRLLLLCLAGLVFVSEAGPAGAGESKCPLMVKVLDAVRGSPAVNVGVKVFKKAADGTWEPFALGKTSEFGELHGLTTDEKFVEGIYKVELDTKSYWKALGISPFHEYAEVVFTANDSGRRHYTIAALLSPYSYSTTALVSSPKE
>NP_001009800.1 transthyretin precursor [Ovis aries]
MASFRLLLLCLAGLVFVSEASPAGAGESKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTSDSGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>NP_001005598.2 transthyretin precursor [Danio rerio]
MAKE-VICVLLASLFALCRSAPVGGSDAHCPLTVKILDAVKGTPAGNIALDLFRQDQGGTWEKIASGKVDMTGEVHNLITEQEFTPGVYRVEFDTLTYWKTEGRTPFHQLADVVFEAHAEGHRHYTLALLLSPFSYTTTAVVVKAHD
>XP_537290.1 transthyretin [Canis lupus familiaris]
MASHRLLLLCLAGLVLVSEASPAGTSGPKCPLMVKVLDAVRGSPAVNVAVKVFKKTADETWEPFASGKTSEFGELHGLTTVEKFVEGVYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSNPKE
>NP_001009137.1 transthyretin precursor [Pan troglodytes]
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFKKAADETWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTIPKE
>NP_001127064.1 transthyretin precursor [Pongo abelii]
MASHRLLLLCLAGLVFVSEAGPTGAGESKCPLMVKVLDAVRGSPAVNVAVNVFKRAADETWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFAANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
>XP_002713532.1 PREDICTED: transthyretin [Oryctolagus cuniculus]
MASQHLLLLCLAGLVFVSEAGPVGTGDSKCPLMVKVLDAVRGSPAVDVSVHVFKKAADETWEPFASGKTSKTGELHGLTTSEKFVEGVYKVELDTKSYWKALGISPFHEYAEVVFTANDSGHRSYTIAALLSPFSYSTTAVVSNPQE
>NP_001278332.1 transthyretin precursor [Meleagris gallopavo]
MAFHSTLLVFLAGLVFLSEAAPLGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKKAADGTWQDFATGKTTEYGEIHELTTEEQFVEGVYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYSTTAVVSDPQE
>XP_003830303.2 transthyretin [Pan paniscus]
MASHHLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFKKAADETWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTIPKE
>NP_001274485.1 transthyretin precursor [Felis catus]
MASH-LLLLCLAGLVLVSEAGPAGTGESKCPLMVKVLDAVQGSPAVNVAVKVFKKAADESWEPFASGKTSEFGELHGLTTAENFVEGVYKVEIDTKSYWKSLGISPFHEYAEVVFTANNSGSRHYTIAALLSPYSYSTTALVSSPKE
>XP_004059337.1 transthyretin [Gorilla gorilla gorilla]
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPATNVAVHVFKKGADETWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
>XP_005697069.1 PREDICTED: transthyretin [Capra hircus]
MASFRLLLLCLAGLVFVSEASPAGAGESKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTSDSGELHGLTTEDKFVEGLYKVELDTKSYWKSLGISPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>XP_006016463.1 transthyretin [Alligator sinensis]
MAFQSMLLVFLAGLVFLSEAAPLGSIDSKCPLMVKVLDAVRGSPAANVAIKVFKKTSDGDWQEFAAGKTTEFGEVHELTSDDKFVEGIYRVEFDTSSYWKALGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYSTTAVVSDPQE
>XP_006271319.1 PREDICTED: transthyretin [Alligator mississippiensis]
MAFQSMLLVFLAGLVFLSEAAPLGSIDSKCPLMVKVLDAVRGSPAANVAIKVFKKTSDGDWQEFAAGKTTEFGEVHELTSDDKFVEGIYRVEFDTSSYWKALGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYSTTAVVSDPQE
>XP_020757674.1 transthyretin [Odocoileus virginianus texanus]
MASFRLFLLCLAGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTSESGELHRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>XP_030288250.1 transthyretin-like [Sparus aurata]
MLQP-LHCLLLASAVLLCNTAPTGGSDTRCPLMVKILDAVKGTPAGSVALKVSQKTADGAWTQIATGLTDATGEIHNLITEQQFPAGVYRVEFDTKAYWTNQGSTPFHEVAEVVFDAHPEGHRHYTLALLLSPFSYTTTAVVSSVHE
>XP_040210045.1 transthyretin [Rana temporaria]
MAYYNTLVLLTIFIF--SGGFHQGEADSKCPLMVKVLDAVRGIPVAKLPVKVFKQNEDKSWGLISSGTTSSDGEIHNLITEEQFVEGIYKLEFATKRYWSKLGLSPFHEYVDVVFTANDAGHRHYTIAVLLTPYSFSTTAVVSDLKE
>XP_011682724.1 transthyretin isoform X2 [Strongylocentrotus purpuratus]
MHSGKMNCAVDDKLYFRKGSRSTAGGKPNSPLTSHVLDTARGSPAANLRIEVYHL-MAGQWKKISEGQTNSDGRCPGLLTMEQFIPGIYKILFDTGSYFKANNIKGFYPFVEIVFEIEDV-NQHYHVPLLLSPFSYSTYRGS-----
>KAB0363513.1 hypothetical protein FD754_007669 [Muntiacus muntjak]
MASLRLFLLCLAGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAANVGVKVFKKAADETWEPFASGKTAESGELHRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>XP_043300308.1 transthyretin [Cervus canadensis]
MASFRLFLLCLSGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAADVGVKVFKKAADETWEPFASGKTSESGELHRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>OWK01751.1 TTR [Cervus elaphus hippelaphus]
MASFRLFLLCLSGLVFVSEAGPPGAGEPKCPLMVKVLDAVRGSPAADVGVKVFKKAAEETWEPFASGKTSESGELHRLTTEDKFVEGLYKVELDTKSYWKSLGITPFHEYAEVVFTANDSGLRHYTIAALLSPYSYSTTALVSSPKE
>XP_005504287.1 transthyretin [Columba livia]
MAFHSVFFVFLAGLVLFSEAAPLGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKKAADGSWQDFAAGKTTEYGEIHDLTTDEQFVEGIYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYSTTAVVTVPQE
>NP_001081348.1 transthyretin precursor [Xenopus laevis]
MASFKSFLL-LALLAIVSEAAPPGEADSKCPLMVKVLDAVRGIPAANLLVNVFRQTESGKWEQITSGKTTELGEIHNLTTDEQFTEGVYKIEFATKAFWGKLGLSPFHEYVDVVFTANDAGHRQYTIAVLLTPYSFSSTAIVSEPHD
>XP_015808416.1 PREDICTED: transthyretin isoform X2 [Nothobranchius furzeri]
M------------------------AGSPSPLTTHVLNTAAGVPGSNMTIKLYQQSVTKVWQLINTGTTNDDGRCPGLITKQQFIPGEYKMHFETARYWAGMGESSFYPYVEIAFTITDA-DQKYHVPLLVSRFSYSTYRGS-----

PhyML tree of selected proteins

(XP_011682724_1_transthyretin_isoform_X2__Strongylocentrotus_purpuratus_:0.4928994,XP_015808416_1_PREDICTED__transthyretin_isoform_X2__Nothobranchius_furzeri_:0.72151045,((XP_030288250_1_transthyretin_like__Sparus_aurata_:0.25473851,NP_001005598_2_transthyretin_precursor__Danio_rerio_:0.36230976):0.31532744,((NP_001081348_1_transthyretin_precursor__Xenopus_laevis_:0.19927205,XP_040210045_1_transthyretin__Rana_temporaria_:0.36267844):0.21923836,((((XP_002713532_1_PREDICTED__transthyretin__Oryctolagus_cuniculus_:0.08762742,(XP_004059337_1_transthyretin__Gorilla_gorilla_gorilla_:0.01477229,(NP_001127064_1_transthyretin_precursor__Pongo_abelii_:0.03097215,(sp_P02766_TTHY_HUMAN_Transthyretin_OS_Homo_sapiens_OX_9606_GN_TTR_PE_1_SV_1:0.01468774,(XP_003830303_2_transthyretin__Pan_paniscus_:0.00726534,NP_001009137_1_transthyretin_precursor__Pan_troglodytes_:0.00000001):0.00750184):0.00616548):0.00000001):0.06564088):0.01185189,((NP_999377_1_transthyretin_precursor__Sus_scrofa_:0.04175016,((NP_001009800_1_transthyretin_precursor__Ovis_aries_:0.00000001,XP_005697069_1_PREDICTED__transthyretin__Capra_hircus_:0.00000001):0.01491353,(NP_776392_1_transthyretin_precursor__Bos_taurus_:0.03772541,((KAB0363513_1_hypothetical_protein_FD754_007669__Muntiacus_muntjak_:0.0152837,XP_020757674_1_transthyretin__Odocoileus_virginianus_texanus_:0):0,(XP_043300308_1_transthyretin__Cervus_canadensis_:0.00000001,OWK01751_1_TTR__Cervus_elaphus_hippelaphus_:0.00757498):0.01522078):0.02256456):0.01668278):0.04198507):0.03281745,(NP_001274485_1_transthyretin_precursor__Felis_catus_:0.05404948,XP_537290_1_transthyretin__Canis_lupus_familiaris_:0.05133644):0.01888989):0.0315346):0.02554675,(NP_036813_2_transthyretin_precursor__Rattus_norvegicus_:0.03176271,NP_038725_1_transthyretin_precursor__Mus_musculus_:0.0368076):0.0705654):0.15037695,(NP_001268427_1_transthyretin_isoform_2__Gallus_gallus_:0.06809258,(NP_001278332_1_transthyretin_precursor__Meleagris_gallopavo_:0.00000001,(XP_005504287_1_transthyretin__Columba_livia_:0.06900008,(XP_006016463_1_transthyretin__Alligator_sinensis_:0.00000001,XP_006271319_1_PREDICTED__transthyretin__Alligator_mississippiensis_:0.00000001):0.11228711):0.02709266):0.022461):0.10344101):0.07739297):0.14867009):1.48184876);

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)